Half-year follow-up of ultrasound cycloplasty for refractory glaucoma

doi:10.3877/cma.j.issn.2095-2007.2019.06.008

Abstract

Abstract:

Objective

The aim of this study was to evaluate the efficacy and safety of ultrasound cycloplasty (UCP) in the treatment of refractory glaucoma.

Methods

11 patients (11 eyes) with refractory glaucoma diagnosed by the Beijing Tongren Eye Center of Beijing Tongren Hospital Affiliated to Capital Medical University were collected, including 6 males (6 eyes) and 5 females (5 eyes), age (28 to 68) with an average age of (48.0±20.4) years. Among of them, there were 1 case with primary angle closure glaucoma, 5 cases with secondary glaucoma caused by vitrectomy or other diseases, 3 cases with neovascular glaucoma and 2 cases with primary angle closure glaucoma. All patients′ examinations were included the best corrected vision, slit lamp biomicroscopy, fundus examination, intraocular pressure measurement, optical biometry and ultrasound biomicroscopy. After UCP, the evaluation of the efficacy was represented as the mean reduction of intraocular pressure and the success rate after 6 months. The mean±SD was used to describe the data. When the data collected during follow-up stage were missing, the mixed effect model was used to compare the changes of intraocular pressure at different time points. Wilcoxon test was used to compare the changes of using drugs to reduce intraocular pressure before and after surgery. Linear regression analysis was used to compare the difference between preoperative intraocular pressure and intraocular pressure reduction at the final follow-up.

Results

11 eyes of 11 patients were treated with UCP. The success rate was 54% (6/11) after 3 months and 36% (4/11) after 6 months. The mean intraocular pressure was (40.82±3.47) mmHg (1 mmHg=0.133 kPa) before operation and (20.26±3.43) mmHg for 7 days after operation; the mean intraocular pressure was (19.89±4.35) mmHg for 3 months after operation; the mean intraocular pressure was (22.06±5.15) mmHg for 6 months after operation. Compared with before operation, there were statistical differences (t=-3.80, -3.05, -4.23; P<0.05). At 6 months after operation, the average antihypertensive drugs decreased from 3.09±0.3 to 2.3±0.2 with statistical difference between them (Z=7.27, P<0.05).

Conclusions

After 6 month post-operation, UCP was safe and effective in reducing intraocular pressure, but its outcome is needed to determine with a longer follow-up .

Key words: Ultrasound cycloplasty, High intensity focused ultrasound, Refractory glaucoma, Intraocular pressure

Dapeng Mou, Xin Tang, Wenzai An, Lei Li, Guoping Qing, Yanzheng Song, Yi Shi. Half-year follow-up of ultrasound cycloplasty for refractory glaucoma[J]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2019, 09(06): 366-371.

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References 44

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