Application of magnetic resonance imaging in measuring the width of optic nerve subarachnoid space width

doi:10.3877/cma.j.issn.2095-2007.2019.01.005

Abstract

Abstract:

Objective

The aim of this study was to study the feasibility of detecting optic nerve subarachnoid space width (ONSWASW) in healthy people, normal intraocular pressure glaucoma (NTG) patients, high intraocular pressure glaucoma (HTG) patients, and ocular hypertension (OHT) patients, with T₂-weighted sequence of magnetic resonance imaging, and analyze the characteristics of ONSASW.

Methods

From May 2013 to December 2014, 15 NTG patients (30 eyes), 11 males (22 eyes), 4 females (8 eyes), an average age of (50.1±5.1), 27 HTG patients (54 eyes), 19 males (38 eyes), 8 females (16 eyes), an average age of (51.4±6.2), 12 OHT patients (24 eyes), 9 males (18 eyes), 3 females (6 eyes), an average age of (48.5±4.8), 32 healthy people (64 eyes), 17 males (34 eyes), 15 females (30 eyes), an average age of (48.3±6.8), were collected in the Third Medical Center of Chinese PLA General Hospital. The intraorbital optic nerve of all the subjects was examined by MRI to measure the diameter of optic nerve and optic nerve sheath at 3 mm, 9 mm, and 15 mm behind the bulbus oculi. Intraorbital optic nerve, optic nerve sheath, and ONSASW were measured repeatly between groups, and compared by two-factor repeated measurement variance analysis.

Results

There was no significant difference between NTG group, HTG goup, OHT group, and control group on sex, age, height, weight, and mean arterial pressure (χ²=3.31; F=1.43, 0.64, 0.78, 0.82, 0.85; P>0.05). The diameter of optic nerve, at 3 mm, 9 mm, and 15 mm behind the bulbus oculi, of NTG group was (3.20±0.23) mm, (2.56±0.18) mm, and (2.42±0.18) mm, HTG group was (3.29±0.28) mm, (2.52±0.19) mm, and (2.26±0.20) mm, OHT group was (3.38±0.21) mm, (2.60±0.15) mm, and (2.32±0.15) mm, control group was (3.33±0.17) mm, (2.85±0.12) mm, and (2.68±0.87) mm, respectively. Compared with the three measurement positions in the same group, the diameter of the optic nerve was shorter if farther from the back of bulbus oculi, which showed statistically significant difference (F=13.59, 18.57, 17.54, 16.51; P<0.05). At 3 mm behind the bulbus oculi, the diameter of the optic nerve of NTG group was shorter than that of OHT group, which showed statistical significance difference (t=2.12, P<0.05); at 9 mm both HTG group and NTG group were shorter than control group (t=3.45, 3.12; P<0.05); at 15 mm HTG group was shorter than control group (t=2.45, P<0.05). The diameter of optic nerve sheath, at 3 mm, 9 mm, and 15 mm behind the bulbus oculi, of NTG group was (4.56±0.26) mm, (3.67±0.32) mm, and (3.35±0.21) mm, HTG group was (5.11±0.35) mm, (3.90±0.23) mm, and (3.90±0.14) mm, OHT group was (5.32±0.25) mm, (3.89±0.26) mm, and (3.92±0.13) mm, control group was (5.03±0.23) mm, (4.22±0.10) mm, and (3.88±0.14) mm, respectively, which showed statistically significant difference in the same group (F=406.15, 202.72, 107.54, 411.35; P<0.05), while, shorter in NTG group compared with control group, HTG group, and OHT group (3 mm: t=6.26, 5.31, 7.68; P<0.05. 9 mm: t=8.92, 4.78, 4.35; P<0.05. 15 mm: t=3.67, 3.97, 4.35; P<0.05). The ONSASW, at 3 mm, 9 mm, and 15 mm behind the bulbus oculi, of NTG group was (0.67±0.10) mm, (0.55±0.08) mm, and (0.50±0.08) mm, HTG group was (0.84±0.07) mm, (0.67±0.04) mm, and (0.62±0.06) mm, OHT group was (0.90±0.07) mm, (0.74±0.04) mm, and (0.66±0.03) mm, and control group was (0.86±0.08) mm, (0.66±0.03) mm, and (0.61±0.04) mm, respectively. The ONSASW would become narrow if near to orbit apex, which showed statistically significant difference (F=188.76, 106.66, 15.07, 30.45; P<0.05). At 3 mm behind the bulbus oculi, the ONSASW of NTG group was narrower than that of HTG group, OHT group, and control group (t=5.82, 7.83, 6.55; P<0.05), while, OHT group was wider than HTG group (t=2.47, P<0.05). At 9 mm behind the bulbus oculi, the ONSASW of NTG group was narrower than that of HTG group, OHT group, and control group (t=3.34, 5.42, 3.24; P<0.05), while, OHT group was wider than HTG group and control group (t=2.45, 2.14; P<0.05). At 15 mm behind the bulbus oculi, the ONSASW of NTG group was narrower than that of HTG group, OHT group, and control group (t=3.21, 4.14, 2.98; P<0.05), while, OHT group was wider than HTG group and control group (t=3.92, 4.01; P<0.05).

Conclusion

ONSASW could be measured by MRI T₂ weighted sequence. The ONSASW is narrower and diameter of the optic nerve is shorter if farther from the back of the bulbus oculi. The diameter of optic nerve of HTG and NTG patients is shorter than healthy people. The ONSASW of NTG patients is the narrowest, OHT patients is the widest, healthy people and HTG patients were in middle.

Key words: Intraocular pressure, Intracranial pressure, Trans-lamina cribrosa pressure difference (TLCPD), Magnetic resonance imaging, Glaucoma, Ocular hypertension

Haihua Sun, Xue Wang, Zhihong Wu, Yuru Dong, Dongsheng Wang. Application of magnetic resonance imaging in measuring the width of optic nerve subarachnoid space width[J]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2019, 09(01): 28-37.

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References 47

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组别	例数	年龄(岁)	性别(男/女)	身高(cm)	体重(kg)	身体质量指数(kg/m²)	平均动脉压(mmHg)	平均眼压(mmHg)
对照组	32	48.3±6.8	17/15	167.9±4.8	64.7±5.2	22.9±1.2	98.7±2.8	13.7±1.3
HTG组	27	51.4±6.2	19/8	169.5±4.8	65.2±3.0	22.7±0.9	96.4±4.7	24.6±1.8
NTG组	15	50.1±5.1	11/4	169.6±6.6	65.4±4.9	22.7±1.3	97.0±4.2	14.8±1.4
OHT组	12	48.5±4.8	9/3	168.7±3.9	65.3±2.6	22.9±0.9	96.7±7.8	28.2±1.9
统计值		1.43^*	3.31^**	0.64^*	0.78^*	0.82^*	0.85^*	404.55^*
P值		>0.05	>0.05	>0.05	>0.05	>0.05	>0.05	<0.05

组别	例数	年龄(岁)	性别(男/女)	身高(cm)	体重(kg)	身体质量指数(kg/m²)	平均动脉压(mmHg)	平均眼压(mmHg)
对照组	32	48.3±6.8	17/15	167.9±4.8	64.7±5.2	22.9±1.2	98.7±2.8	13.7±1.3
HTG组	27	51.4±6.2	19/8	169.5±4.8	65.2±3.0	22.7±0.9	96.4±4.7	24.6±1.8
NTG组	15	50.1±5.1	11/4	169.6±6.6	65.4±4.9	22.7±1.3	97.0±4.2	14.8±1.4
OHT组	12	48.5±4.8	9/3	168.7±3.9	65.3±2.6	22.9±0.9	96.7±7.8	28.2±1.9
统计值		1.43^*	3.31^**	0.64^*	0.78^*	0.82^*	0.85^*	404.55^*
P值		>0.05	>0.05	>0.05	>0.05	>0.05	>0.05	<0.05

组别	例数	球后3 mm部	球后9 mm部	球后15 mm部
对照组	32例	3.33±0.17	2.85±0.12	2.68±0.87
HTG组	27例	3.29±0.28	2.52±0.19	2.26±0.20
NTG组	15例	3.20±0.23	2.56±0.18	2.42±0.18
OHT组	12例	3.38±0.21	2.60±0.15	2.32±0.15
F值		2.54	24.60	10.88
P值		<0.05	<0.05	<0.05

组别	例数	球后3 mm部	球后9 mm部	球后15 mm部
对照组	32例	3.33±0.17	2.85±0.12	2.68±0.87
HTG组	27例	3.29±0.28	2.52±0.19	2.26±0.20
NTG组	15例	3.20±0.23	2.56±0.18	2.42±0.18
OHT组	12例	3.38±0.21	2.60±0.15	2.32±0.15
F值		2.54	24.60	10.88
P值		<0.05	<0.05	<0.05

组别	例数	球后3 mm部	球后9 mm部	球后15 mm部
对照组	32例	5.03±0.23	4.22±0.10	3.88±0.14
HTG组	27例	5.11±0.35	3.90±0.23	3.90±0.14
NTG组	15例	4.56±0.26	3.67±0.32	3.35±0.21
OHT组	12例	5.32±0.25	3.89±0.26	3.92±0.13
F值		18.93	15.60	9.75
P值		<0.05	<0.05	<0.05

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