The aim of this study was to explore the effect of three non steroidal anti-inflammatory drugs in the perioperative period of phacoemulsification combined with intraocular lens implantation.

From July 2018 to January 2019, 122 patients (122 eyes) with cataract surgery in Eye Center of the Second Affiliated Hospital, Zhejiang University Medical College were selected. Among them, 36 cases (36 eyes) were male, 86 cases (86 eyes) were female, and the average age was (68.2±10.2) years-old. The patients were randomly divided into A group, B group and C group. All patients were underwent phacoemulsification combined with intraocular lens implantation, and 0.1% pramiphene eye drops, 0.1% sodium bromfenate eye drops and 0.1% diclofenac sodium eye drops were used in the perioperative period. The age, phacoemulsification energy and effective phacoemulsification time of patients were described by(±s), and one-way ANOVA was used for comparison between groups. The scores of intraocular pressure, anterior chamber flash, central corneal thickness, postoperative dry eye condition and conscious symptoms were described by(±s) and ANOVA. The incidence of severe postoperative symptoms was expressed by the number and percentage, and the chi-square test was performed.

Intraocular pressure of all groups before operation were (13.55±2.88) mmHg (1 mmHg=0.133 kPa), (13.16±3.71) mmHg and (13.83±2.74) mmHg; 1 d after operation, they were (15.21±3.71) mmHg, (14.46±4.78) mmHg and (14.73±4.04) mmHg, respectively; 7 d after operation, they were (14.19±3.34) mmHg, (13.66±3.46) mmHg and (14.56±3.65) mmHg, respectively; 30 d after operation, they were (12.68±2.69) mmHg, (12.16±3.65) mmHg and (12.89±3.17) mmHg, respectively. There was no significant difference among three groups before operation, 1 d after operation, 7 d after operation and 30 d after operation (F=0.49, 0.12, 0.65, 0.59; P>0.05). All patients′ anterior chamber flash value before operation were (6.09±2.98) pc/ms, (6.81±2.93) pc/ms and (7.31±5.87) pc/ms, respectively; 1 d after operation, they were (13.04±6.92) pc/ms, (12.72±11.53) pc/ms and (14.22±11.31) pc/ms, respectively; 7d after operation, they were (7.77±3.73) pc/ms, (6.99±4.19) pc/ms and (8.14±3.15) pc/ms, respectively; 30 d after operation, they were (7.06±3.72) pc/ms, (8.21±3.16) pc/ms and (9.29±4.97) pc/ms, respectively. There was no significant difference among three groups before operation, 1 d, 7 d and 30 d after operation (F=0.90, 0.25, 0.97, 2.99; P>0.05). The central corneal thickness of all patients before operation were (536.05±30.07) μm, (537.08±30.08) μm and (523.14±38.65) μm, respectively; 1 d after operation, they were (628.91±84.20) μm, (674.94±154.43) μm and (619.02±144.65) μm, and 7 d after operation, they were (550.59±38.64) μm, (553.14±35.43) μm and (543.31±45.51) μm, respectively; 30 d after operation, they were (539.93±33.98) μm, (549.27±34.14) μm and (527.78±78.74) μm, respectively. There was no significant difference among three groups before operation, 1 d, 7 d and 30 d after operation (F=2.22, 2.02, 0.64, 1.45; P>0.05). The height of lacrimal river in all groups before operation were (0.18±0.08) mm, (0.21±0.11) mm and (0.22±0.09) mm, respectively; 7 d after operation, they were (0.19±0.08) mm, (0.19±0.08) mm and (0.25±0.15) mm, respectively; 30 d after the operation, they were (0.22±0.11) mm, (0.23±0.12) mm and (0.24±0.15) mm, respectively. The difference of 7 d after operation was statistically significant (F=4.97, P<0.05). The scores of conscious symptoms in 3 groups 7 d after operation were (1.95±2.39), (2.19±2.54) and (1.45±1.25), respectively; 30 d after operation, those were (2.33±2.03), (1.73±2.02) and (1.51±2.02), respectively. There was no significant difference between three groups in 7 d and 30 d after operation (F=1.27, 1.74; P>0.05). The proportion of patients in 3 groups with severe (scores≥3), 7 d after operation, 20.5%, 38.9% and 21.4%, respectively; 30 d after operation, 38.6%, 25.0% and 16.7%, respectively. There was a significant difference between three groups in 7 d and 30 d after operation (χ²=218.45, 160.82; P<0.05).

Three groups of non steroidal anti-inflammatory drugs have the same anti-inflammatory effect in the perioperative period of cataract phacoemulsification; C group was better than others in relieving dry eyes after cataract surgery. The score of postoperative conscious symptoms in C group was better than other groups.