Comparisons on the correlation and agreement between two non-contact tonometers

doi:10.3877/cma.j.issn.2095-2007.2019.03.003

Abstract

Abstract:

Objective

The aim of this study was to explore the correlation and the agreement between the intraocular pressure (IOP) measured by two different non-contact tonometers in healthy eyes and evaluate the impact of central corneal thickness (CCT) and corneal curvature (Ks, Kf) on the IOP measurements.

Methods

In the cross-sectional study, the case data of 71 patients (142 eyes) who were examined in Beijing Tongren Eye Center of Capital Medical University were collected from March 2018 to April 2018. IOP was measured sequentially with the Canon TX20 (Canon Inc., Janpan), VX120 (Luneau Technology USA), including CCT corrected IOP . CCT was measured using VX120. Ks and Kf were measured using Corneal Topographer. The relationships between different parameters and the measured IOP with each device were evaluated by Wilcoxon test with Spearman correlation analysis. Bland-Altman plot and 95% limit of agreement (LoA) of IOPs was analyzed.

Results

The IOP measured by CanonTX20, VX120 and IOP measured by VX120 after correction were (15.7±2.5) mmHg (1 mmHg=0.133 kPa), (16.7±3.4) mmHg, (16.8±3.3) mmHg, respectively; and IOP among of them were not shown the statistically on the gender (Z=0.295, 0.366, 0.131; P>0.05). There was a positive correlation between IOP measured by CanonTX20 , VX120 and CCT measured by VX120, Lenstar LS900(r=0.177, 0.167, 0.221, 0.178; P<0.05). There was not shown a correlation between corrected IOP measured by VX120 and CCT measured by VX120, Lenstar LS900 (r=0.026, r=-0.001; P>0.05). The correlation coefficients of IOP measured by three methods, Ks and Kf were not statistically significant (r=0.158, 0.158; P>0.05). The IOP measured by CanonTX20 was (1.007±2.651) mmHg higher than that measured by CanonTX20 (t=-4.527, P<0.05). Blander-Altman plot and 95% consistency threshold analysis showed that 95% LoA of them was ± 5.2 mmHg. Additionally, there was no obvious linear trend between age and IOP.

Conclusion

The IOP measured by CanonTX20 and VX120 were shown a bad consistency, which suggesting they cannot be used interchangeably to measure IOP in clinical practice. There was a correlation between CCT and IOP measured by CanonTX20, VX120, but there was no correlation between corrected IOP measured by VX120 and CCT. The correlations between Ks, Kf and IOP were not found.

Key words: Non-contact tonometer intraocular pressure, Corneal curvature, Corneal thickness, Correlation analysis

Qingwei Zhang, Changbin Zhai, Jing Zhang, Yan Zheng, Yue Wang, Jing Liu, Ningli Wang, Yuehua Zhou. Comparisons on the correlation and agreement between two non-contact tonometers[J]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2019, 09(03): 140-145.

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