Abstract:

Dry eye affects the lives ofmillions of people every year，yet a cure has still not been found.Increasing evidence suggests that dysregulation of the gut microbiome is linked to ocular surface diseases.The imbalance in the gut microbiome can cause barrier disruption，influence local or systemic inflammation，and lead to pathological changes in distant organs，with the connection between the gut microbiome and autoimmune diseases being a focus of attention.There have been nearly 300 studies on the relationship between the gutmicrobiome and eye diseases，including immune-mediated eye diseases，diabetic retinopathy，age-related macular degeneration，dry eye，and Graves′ophthalmopathy，amongwhich dry eye provides the best evidence of the interaction.The research progress on the relationship between dry eyerelated diseases and the gutmicrobiome was reviewed，in order to explore the connection between dry eye and the gutmicrobiome to help understand its pathogenesis，provide new insights for the prevention of dry eye，and develop new dry eye therapies based on the gutmicrobiome.

Key words: Gut-eye axis, Dry eye, Primary Sj?gren′s syndrome, Gutmicrobiome