Advances on the vitamin D and ocular disease

doi:10.3877/cma.j.issn.2095-2007.2023.06.009

Abstract

Abstract:

Vitamin D is a steroid hormone that has widespread role in human physiology, not only in the maintenance of calcium homeostasis but also in immunomodulation, cellular differentiation, and proliferation. The role of vitamin D in ocular surface conditions such as dry eye disease, diabetic retinopathy, and thyroid eye disease has received widespread and well deserved attention. It has been demonstrated that vitamin D has associated with eye diseases including myopia, age-related macular degeneration (AMD), glaucoma, DR, dry eye, thyroid related eye diseases, uveitis, retinoblastoma, and cataracts. The correlation between vitamin D and eye diseases from the perspective of vitamin D metabolism was reviewed, aiming to provide new ideas for the diagnosis and treatment of eye diseases.

Key words: Vitamin D, Diabetic retinopathy, Dry eye syndrome, Myopia, Age-related macular degeneration, Thyroid eye disease

Xinxing Li, Yanhong Fang, Huinzhen Chen, Lanyue Zhang, Han Liu. Advances on the vitamin D and ocular disease[J]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2023, 13(06): 366-370.

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References 55

[1]	Valle MS, Russo C, Malaguarnera L. Protective role of vitamin D against oxidative stress in diabetic retinopathy[J]. Diabetes Metab Res Rev, 2021, 37(8): e3447.
[2]	Cojic M, Kocic R, Klisic A, et al. The effects of vitamin d supplementation on metabolic and oxidative stress markers in patients with type 2 diabetes: a 6 month follow up randomized controlled study [J]. Front Endocrinol, 2021, 12: 610893.
[3]	Sharif AF, Hafezi S, Sharif AN, et al. Vitamin D modulates systemic inflammation in patients with severe COVID－19[J]. Life Sci, 2022, 307: 120909.
[4]	Alsalem JA, Patel D, Susarla R, et al. Characterization of vitamin D production by human ocular barrier cells[J]. Invest Ophthalmol Vis Sci, 2014, 55(4): 2140－2147.
[5]	Rullo J, Pennimpede T, Mehraban FP, et al. Intraocular calcidiol: Uncovering a role for vitamin D in the eye[J]. J Steroid Biochem Mol Biol, 2020, 197(C): 105536.
[6]	Lee JH, Kim SJ, Byun YS, et al. The association of serum vitamin d level with the severity of dry eye parameters in primary Sjogren syndrome[J]. Cornea, 2020, 39(39): 702－705.
[7]	Fukuoka S, Arita R, Mizoguchi T, rt al. Relation of dietary fatty acids and vitamin d to the prevalence of meibomian gland dysfunction in Japanese adults: The Hirado－Takushima Study[J]. J Clinical Med, 2021, 10(2): 350.
[8]	Arman A, Petricli IS, Kara C, et al. The relationship between serum vitamin D levels and dry eye syndrome in postmenopausal women[J]. Ann Clin Anal Med, 2020, 11: 91－94.
[9]	Eslampoor A, Najjaran M, Arjmand－Askari E, et al. Effect of oral vitamin D supplementation on dry eye disease patients with vitamin D deficiency[J]. Clin Exp Optom, 2022, 106(3): 1－6.
[10]	Watts P, Sahai A, Kumar PR, et al. A prospective study to assess the role of vitamin D individually and in combination with cyclosporine in the treatment of dry eye in patients with deficient serum 25(OH)D levels[J]. Indian J Ophthalmol, 2020, 68(6): 1020－1026.
[11]	张丽娟，梁荣斌，邵毅．维生素D缺乏与干眼关系的研究进展[J]．眼科新进展，2021，41(8)：794－796，800.
[12]	Eksioglu U, Atilgan HI, Yakin M, et al. Antioxidant effects of vitamin D on lacrimal glands against high dose radioiodine－associated damage in an animal model[J]．Cutan Ocul Toxicol, 2019, 38(1) : 18－24.
[13]	Bascom A, Redfern RL, Reins RY. Characterization of vitamin D levels in ocular surface tissues and their association with dry eye disease[J]. Investig Ophthalmol Vis Sci, 2019, 60: 1414.
[14]	Nadri G, Saxena S, Kaur A, et al. Correlation between vitamin D serum levels and severity of diabetic retinopathy in patients with type 2 diabetes mellitus[J]. J. Endocrino Metab Diabetes South Afr, 2021, 26(3): 82－88.
[15]	Castillo－Oti JM, Galvan－Manso AI, Callejas－Herrero MR, et al. Vitamin D deficiency is significantly associated with retinopathy in type 2 diabetes mellitus: A Case－Control Study[J]. Nutrients, 2021, 14(1): 84.
[16]	Tomic M, Vrabec R, Ljubic S, et al. Plasma homocysteine is associated with nonproliferative retinopathy in patients with type 2 diabetes without renal disease[J]. Diabetes Metab Syndr, 2022, 16(1): 102355.
[17]	Girard E, Nacher M, Bukasa－Kakamba J, et al. Vitamin D deficiency in patients with diabetes in french guiana: epidemiology and relation with microvascular and macrovascular complications[J]. Nutrients, 2021, 13(12): 4302.
[18]	Xiao Y, Wei L, Xiong X, et al. Association between vitamin d status and diabetic complications in patients with type 2 diabetes mellitus: a cross－sectional study in Hunan China[J]. Front Endocrinol, 2020, 11: 564738.
[19]	Merrigan SL, Park B, Ali Z, et al. Calcitriol and non－calcemic vitamin D analogue, 22－oxacalcitriol, attenuate developmental and pathological choroidal vasculature angiogenesis ex vivo and in vivo[J]. Oncotarget, 2020, 11(5): 493－509.
[20]	Tohari AM, Almarhoun M, Alhasani RH, et al. Protection by vitamin D against high－glucose－induced damage in retinal pigment epithelial cells[J]. Exp Cell Res, 2020, 392(1): 112023.
[21]	Jung BJ, Jee D. Association between serum 25－hydroxyvitamin D levels and myopia in general Korean adults[J]. Indian J Ophthalmol, 2020, 68(1): 15－22.
[22]	Gao F, Li P, Liu YQ, et al. Association study of the serum 25(OH)D concentration and myopia in Chinese children[J]. Medicine, 2021, 100(26): e26570.
[23]	Specht IO, Jacobsen N, Frederiksen P, et al. Neonatal vitamin D status and myopia in young adult men[J]. Acta Ophthalmol, 2020, 98(5): 500－505.
[24]	Harb EN, Wildsoet CF. Nutritional factors and myopia: an analysis of national health and nutrition examination survey data[J]. Optom Vis Sci, 2021, 98(5): 458－468.
[25]	Chou HD, Yao TC, Huang YS, et al. Myopia in school－aged children with preterm birth: The roles of time spent outdoors and serum vitamin D[J]. Br J Ophthalmol, 2021, 105(4): 468－472.
[26]	Lingham G, Mackey DA, Zhu K, et al. Time spent outdoors through childhood and adolescence－assessed by 25－hydroxyvitamin D concentration－and risk of myopia at 20 years[J]. Acta Ophthalmol, 2021, 99(6): 679－687.
[27]	Tang SM, Lau T, Rong SS, et al. Vitamin D and its pathway genes in myopia: Systematic review and meta－analysis[J]. Br J Ophthalmol, 2019, 103(1): 8－17.
[28]	Hashemi R, Bandarian M, Abedi－Taleb E, et al. The association between blood vitamins D and E with age－related macular degeneration: A pilot study[J]. Interv Med Appl Sci, 2018, 10(3): 127－132.
[29]	Malaguarnera L . Vitamin D and microbiota: Two sides of the same coin in the immunomodulatory aspects [J]. Int Immunopharmacol, 2020, 79: 106112.
[30]	Mahgoub MY, Abou Ghanima AT, Elmohamady MN, et al. Age－Related Macular Degeneration in Primary Osteoarthritis Egyptian Patients[J]. Open Access Rheumatol, 2020, 12, 35－40.
[31]	Christen WG, Cook NR, Manson JE, et al. Effect of vitamin d and omega－3 fatty acid supplementation on risk of age－related macular degeneration: an ancillary study of the VITAL randomized clinical trial[J]. Jama Ophthalmol, 2020, 138: 1280－1289.
[32]	Ayyagari R, Chen YI, Zangwill LM, et al. Association of severity of primary open－angle glaucoma with serum vitamin D levels in patients of African descent[J]. Mol Vis, 2019, 25: 438－445.
[33]	Dikci S, Ozturk E, Firat PG, et al. The Association of serum Vitamin D levels with pseudoexfoliation glaucoma/syndrome[J]. Endocr Metab Immune Disord Drug Targets, 2019, 19(2): 166－170.
[34]	Carbone LD, Johnson K, Larson JC, et al. Association of vitamin D with incident glaucoma: Findings from the Women's Health Initiative[J]. J Investig Med, 2021, 69: 843－850.
[35]	Cho Y, Yun SP, Yoo WS, et al. Reduced 25－hydroxyvitamin D concentration in the aqueous humor f cataract patients with open－angle glaucoma[J]. Sci Rep, 2021, 11(1): 18785.
[36]	Kocaturk T, Bekmez S, Unubol M. Effects of vitamin D deficiency on intraocular pressure values obtained by ocular response nalyzer[J]. Int Ophthalmol, 2020, 40(3): 697－701.
[37]	Lv Y, Yao Q, Ma W, et al. Associations of vitamin D deficiency and vitamin D receptor (Cdx－2, Fok I, Bsm I and Taq I) polymorphisms with the risk of primary open－angle glaucoma[J]．BMC Ophthalmol, 2016, 16: 116.
[38]	梁健，张振，曾怡. Graves眼病患者血清中性粒细胞计数、CRP、ESR、NLR及甲状腺自身抗体的表达和意义[J]. 河北医药，2023，45(11)：1707－1709.
[39]	Sadaka A, Nguyen K, Malik A, et al. Vitamin D and selenium in a thyroid eye disease population in Texas[J]. Neuroophthalmology, 2019, 43(5): 291－294.
[40]	Heisel CJ, Riddering AL, Andrews CA, et al. Serum vitamin D deficiency is an independent risk factor for thyroid eye disease[J]. Ophthalmic Plast Reconstr Surg, 2020, 36(1): 17－20.
[41]	赵长英，甘西伦，王明霜，等．维生素D缺乏与Graves病及其并发症关系的临床研究[J]．重庆医科大学学报，2018，43(6)：814－817.
[42]	Llop SM, Davoudi S, Stanwyck LK, et al. Association of low vitamin d levels with noninfectious uveitis and scleritis[J]. Ocul Immunol Inflamm, 2019, 27(4): 602－609.
[43]	Rohmer J, Hadjadj J, Bouzerara A, et al. Serum 1, 25(OH)2 vitamin d and 25(OH) vitamin d ratio for the diagnosis of sarcoidosis－related uveitis[J]. Ocul Immunol Inflamm, 2020, 28(3): 341－347.
[44]	Chiu ZK, Lim LL, Rogers SL, et al. Patterns of vitamin D levels and exposures in active and inactive noninfectious uveitis patients[J]. Ophthalmology, 2020, 127(2): 230－237.
[45]	Pillar S, Amer R. The association between vitamin D and uveitis: A comprehensive review[J]. Surv Ophthalmol, 2021, 67(2): 321－330.
[46]	魏亚萍，褚兆苹，王蓓. 维生素D与肿瘤发生风险的系统评价[J]. 肿瘤代谢与营养电子杂志，2023，10(1)：29－36.
[47]	Schündeln MM, Hauffa PK, Bauer JJ, et al. Pediatric survivors of retinoblastoma are at risk for altered bone metabolism after chemotherapy treatment early in life[J]. Pediatr Hematol Oncol, 2015, 32(7): 455－466, 269.
[48]	Mejia－Rodriguez F, Flores－Aldana ME, Quezada－Sanchez AD, et al. Association between predictors of vitamin d serum levels and risk of retinoblastoma in children: A case－control study[J]. Nutrients, 2021, 13(8): 2510.
[49]	Orjuela－Grimm M, Carreno SB, Liu X, et al. Sunlight exposure in infancy decreases risk of sporadic retinoblastoma, extent of intraocular disease[J]. Cancer Rep, 2021, 4(6): e1409.
[50]	陈晓娟，张国伟，李鹏飞，等. 紫外线照射后人晶状体上皮细胞的iTRAQ定量蛋白质组学研究 [J]. 国际眼科杂志，2023，23(4)：551－556.
[51]	刘兵. 大鼠血清25羟维生素D水平与年龄相关性白内障的关系 [J]. 安徽医药，2019，23(9)：1728－1732.
[52]	Oktem C, Aslan F. Vitamin D levels in young adult cataract patients: a case－control study[J]. Ophthalmic Res, 2021, 64: 116－120.
[53]	朱跃弟，姚琨，姚蕊莲. 中老年人血清25－羟基维生素D水平与老年性白内障发生的相关性分析[J]. 眼科新进展，2019，39(7)：686－689.
[54]	Sorkhabi R, Ahoor MH, Ghorbanihaghjo A, et al. Serum vitamin D levels in patients with vernal keratoconjunctivitis and its relationship with disease severity[J]. Eur J Ophthalmol, 2021, 31(6): 3259－3264.
[55]	Aslan MG, Findik H, Okutucu M, et al. Serum 25－Hydroxy Vitamin D, Vitamin B12, and folic acid levels in progressive and nonprogressive keratoconus[J]. Cornea, 2021, 40: 334－341.

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