Abstract:

Diabetic retinopathy（DR）is one of the most common and severe microvascular complications of diabetes，with a complex pathogenesis.In recent years，research on lipid metabolism abnormalities in retinal pigment epithelial（RPE）cells has gradually paid more attention.RPE cells are crucial components of retinal structure and function，and their lipid metabolism homeostasis is essential for maintaining retinal function and regulating processes such as oxidative stress and inflammatory responses.Abnormal lipid metabolism can lead to structural damage and functional impairment of RPE cells，thus exacerbating the progression of diabetic retinopathy.The role of RPE cells in the occurrence and development of DR，systematically organizes the research progress related to RPE lipid metabolism imbalance and DR was reviewed，which focuses on changes in lipid metabolism-related signaling pathways and their importance in the pathological process of DR，aiming to provide new ideas and reference for the early prevention and treatment，aswell as targeted intervention strategies for DR.

Key words: Diabetic retinopathy, Retinal pigment epithelium cells, Lipid metabolism abnormalities, Signaling pathways, Targeted intervention