Advances in the relationship between gut microbiota and common ocular diseases

doi:10.3877/cma.j.issn.2095-2007.2022.05.009

Abstract

Abstract:

Gut microbiota refers to the collection of microbial communities living in the human intestinal tract, which plays important roles in digestion, metabolism and immune regulation. In recent years, the study on the pathological mechanism of gut microbiota participating in the occurrence and progression of different diseases has become one of the most extended concerned hotspots worldwide nowadays, and the correlation between gut microbiota and the pathogenesis of various eye diseases has been demonstrated. The concept of the gut-eye axis indicates that the gut microbiota has a capacity of affecting the local and peripheral immune responses and participating in the pathological injuries of multiple eye diseases. The latest research progress on the relationship between gut microbiota and different eye diseases including dry eye, glaucoma, uveitis, age-related macular degeneration, and diabetic retinopathy has been syste-matically reviewed in this paper, which to provide new insights into the underlying mechanism and original treatment approaches of common ocular diseases.

Key words: Gut microbiota, Gut-eye axis, Dry eye, Glaucoma, Uveitis

Ying Cheng, Wenzai An, Danting Lin, Ningli Wang. Advances in the relationship between gut microbiota and common ocular diseases[J]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2022, 12(05): 305-309.

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