Abstract:

Diabetes causes diabetic retinopathy (DR) and diabetic macular edema (DME), which are important causes of blindness and low vision in adults. The dyslipidemia is closely associated with DR and DME.Traditional blood lipids such as cholesterol, triglyceride, very low density lipoprotein and low-density lipoprotein may be risk factors for DR, while high-density lipoprotein may be protective. For non-traditional blood lipids, apolipoprotein B, C, E, small and dense low-density lipoprotein cholesterol and lipoprotein a may be risk factors for DR, while apolipoprotein A may be protective. Lipid balance/ratio is more helpful to determine the occurrence and progress of DR. Polyunsaturated fatty acids and their ratios may be related to the pathogenesis of DR. Lipid-lowering drugs statins and fibrates both protect the retina in high glucose environment and have a potential role in inhibiting DR.The correlation between blood lipids and DR was reviewed, aiming to provide a new strategy for DR integrated treatment.

Key words: Diabetic retinopathy, Diabetic macular edema, Diabetes mellitus, Dyslipidemia, Hyperlipidemia