切换至 "中华医学电子期刊资源库"

中华眼科医学杂志(电子版) ›› 2025, Vol. 15 ›› Issue (06) : 369 -373. doi: 10.3877/cma.j.issn.2095-2007.2025.06.009

综述

红、蓝及紫三种单色光对近视眼影响的研究进展
赵四俊, 陈敏锋, 张健, 毛欣杰()   
  1. 325000 温州医科大学附属眼视光医院视光诊疗中心
  • 收稿日期:2025-11-20 出版日期:2025-12-28
  • 通信作者: 毛欣杰
  • 基金资助:
    国家重点研发计划中医药现代化研究重点专项项目(2019YFC1710200)

Advances in effects of red, blue, violet monochromatic lights on myopia

Sijun Zhao, Minfeng Chen, Jian Zhang, Xinjie Mao()   

  1. Optometry Diagnosis and Treatment Center, Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou 325000, China
  • Received:2025-11-20 Published:2025-12-28
  • Corresponding author: Xinjie Mao
引用本文:

赵四俊, 陈敏锋, 张健, 毛欣杰. 红、蓝及紫三种单色光对近视眼影响的研究进展[J/OL]. 中华眼科医学杂志(电子版), 2025, 15(06): 369-373.

Sijun Zhao, Minfeng Chen, Jian Zhang, Xinjie Mao. Advances in effects of red, blue, violet monochromatic lights on myopia[J/OL]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2025, 15(06): 369-373.

近视眼是常见的屈光不正,主要发生在青少年时期,也是全球常见的眼病之一,给全球患者带来了沉重的经济负担。近年来,随着高度近视眼的患病率增加,预计未来几年黄斑病变等相关并发症的发病率也会随之增高。减缓低度近视眼向高度近视眼进展的公共卫生策略是预防与病理性近视眼相关严重疾病和并发症发生的重要环节。目前,近视眼的发病机制研究和对应的干预方式众多,但尚未有根治的方法。基于此,预防近视眼发生和延缓近视眼进展成为主要措施。其中,每天户外活动2 h有利于近视眼防控已成共识,这可能涉及到光照的时长、照度、波长、频率、空间频率以及人眼调节等方面。在动物模型上,近视防控的机制研究涉及多种信号通路,临床上则更加关注有效性和安全性。本文中笔者就当前研究较多的红光、蓝光及紫光对近视眼的影响进行综述,为进一步近视防控与健康光照研究提供一些理论参考。

Myopia is a common refractive error, predominantly occurring in adolescence, and represents one of the most prevalent eye diseases worldwide, imposing a substantial economic burden on patients globally. Particularly, the rising prevalence of high myopia is expected to drive a corresponding increase in the incidence of complications such as myopic maculopathy in the coming years. Public health strategies aimed at slowing the progression from low myopia to high myopia are critical for preventing severe conditions and complications associated with pathological myopia. Numerous studies have explored the pathogenesis of myopia, and a variety of corresponding interventions have been proposed; however, a curative treatment remains elusive. As such, preventing myopia onset and slowing its progression have become the primary measures for addressing the myopia epidemic in contemporary society. Among these, the benefit of 2 hours of daily outdoor activity for myopia control is widely recognized, which may involve factors such as light exposure duration, illuminance, wavelength, frequency, spatial frequency, and ocular accommodation.In animal models, mechanistic studies of myopia control have implicated multiple signaling pathways, while clinical research prioritizes efficacy and safety. The effects of red light, blue light, and violet light—currently the most extensively studied light spectra on myopia were summarized, aiming to provide theoretical references for further research on myopia control and healthy lighting.

表1 红光相关研究的文献汇总表
第一作者(发表年份) 相关光干预 研究对象 相关样本量 有效性和安全性
Liu等[7](2014) 610 nm 幼年恒河猴 9 早期长波长光的照射可能是少数对L锥体刺激敏感的恒河猴近视眼的风险因素
Smith等[8](2015) 红色滤光片 幼年恒河猴 13 未明确长波长环境对促进近视眼的影响
Yu等[8](2021) 重复低水平红光 8~13岁儿童 117 重复低水平红光是一种有前景的近视控制替代疗法,适用于使用良好且无功能或结构损伤的儿童
Xiong等[9](2022) 重复低水平红光 8~13岁儿童 60 重复低水平红光在整个治疗过程中诱导了持续的脉络膜增厚,且3月时的黄斑脉络膜厚度变化即可较准确预测12个月时的控制效果
Meng等[10](2022) 重复低水平红光 儿童 67 脉络膜增厚伴血管管腔和间质区增大,且前者增大幅度更高
Liu等[11](2023) 重复低水平红光 12岁女性 1 重复低水平红光5个月后视网膜损失,双侧视力丧失持续2周;停用3个月,视网膜损伤部分恢复
Liao等[12](2025) 重复低水平红光 5~14岁儿童 52 重复低水平红光治疗至少1年与部分接受近视控制治疗的儿童中央中央凹锥体密度降低及其他细微视网膜异常相关
Zhang等[13](2025) 重复低水平红光 7~12岁儿童 43 3例出现短暂性中央凹视网膜色素上皮高反射,停止治疗后0.5~3个月内缓解,视力未下降
Liu等[14](2025) 重复低水平红光 近视眼前期儿童 58 治疗2年可有效延缓近视眼前期儿童的眼轴伸长和等效球镜屈光度进展,但停用1年后眼轴生长出现显著反弹效应
表2 蓝光相关研究的文献汇总表
表3 紫光相关研究的文献汇总表
[1]
Pan W, Saw SM, Wong TY, et al. Prevalence and temporal trends in myopia and high myopia children in China: a systematic review and meta-analysis with projections from 2020 to 2050[J]. Lancet Reg Health West Pac, 2025, 55: 101484.
[2]
Yu J, Zhuoting Z, Xingping T, et al. Effect of repeated low-level red-light therapy in myopia control in children: a multicenter randomized controlled trial[J]. Ophthalmology, 2021, 129(5): 509-519.
[3]
Shi D, Li J, Dang J, et al. Dual associations of post-sleep and pre-wake light-at-night (LAN) exposure with myopia in children and adolescents[J]. Environmental research, 2025, 279(Pt 2): 121915.
[4]
Jiang X, Pardue MT, Mori K, et al. Violet light suppresses lens-induced myopia via neuropsin (OPN5) in mice[J]. Proc Natl Acad Sci U S A, 2021, 118(22): 1-8.
[5]
Rucker F.Monochromatic and white light and the regulation of eye growth[J]. Experimental Eye Research, 2019, 184172-184182.
[6]
Shunmei J, Xiuyu M, Yifan Z, et al. Contribution of M-opsin-based color vision to refractive development in mice[J]. Experimental eye research, 2021, 209: 108669.
[7]
Liu R, Hu M, He JC, et al. The effects of monochromatic illumination on early eye development in rhesus monkeys[J]. Invest Ophthalmol Vis Sci, 2014, 55(3): 1901-1909.
[8]
Smith EL, Hung LF, Arumugam B, et al. Effects of long-wavelength lighting on refractive development in infant rhesus monkeys[J]. Invest Ophthalmol Vis Sci, 2015, 56(11): 6490-500.
[9]
Ruilin X, Zhuoting Z, Yu J, et al. Longitudinal changes and predictive value of choroidal thickness for myopia control following repeated low-level red-light therapy[J]. Ophthalmology, 2022, 130(3): 286-296.
[10]
Meng X, Zhuoting Z, Yu J, et al. Longitudinal changes in choroidal structure following repeated low-level red-light therapy for myopia control: secondary analysis of a randomized controlled trial[J]. Asia Pac J Ophthalmol (Phila), 2023, 12(4): 377-383.
[11]
Huanyu L, Yuan Y, Jingli G, et al. Retinal damage after repeated low-level red-light laser exposure[J]. JAMA Ophthalmol, 2023, 1548.
[12]
Liao X, Yu J, Fan Y, et al. Cone density changes after repeated low-level red light treatment in children with myopia[J]. JAMA Ophthalmol, 2025, 143(6): 480-488.
[13]
Zhang Z, Hu D, Xu W, et al. Structural OCT changes following repeated low-level red-light therapy for myopia prevention[J]. JAMA Ophthalmol, 2025, 143(10): 876-877.
[14]
Liu G, Li N, Rong H, et al. Two-year outcomes of repeated red light therapy in premyopic children: sustained efficacy and rebound effects[J]. Br J Ophthalmol, 2025, 9: bjo-2025-327600.
[15]
Heinig N, Schumann U, Calzia D, et al. Photobiomodulation mediates neuroprotection against blue light induced retinal photoreceptor degeneration[J]. Int J Mol Sci, 2020, 21(7): 2370.
[16]
Kokkinopoulos I, Colman A, Hogg C, et al. Age-related retinal inflammation is reduced by 670 nm light via increased mitochondrial membrane potential[J]. Neurobiol Aging, 2013, 34(2): 602-609.
[17]
Sivapathasuntharam C, Sivaprasad S, Hogg C, et al. Aging retinal function is improved by near infrared light (670 nm) that is associated with corrected mitochondrial decline[J]. Neurobiol Aging, 2017, 52: 66-70.
[18]
Kokkinopoulos I. 670nm LED ameliorates inflammation in the CFH -/- mouse neural retina[J]. J Photochem Photobiol B, 2013, 122: 24-31.
[19]
Matt R, Riccardo N, Rizalyn A, et al. 670-nm light treatment reduces complement propagation following retinal degeneration[J]. J Neuroinflammation, 2012, 9: 257.
[20]
Min W, Frank S, Bing J, et al. Effects of light of different spectral composition on refractive development and retinal dopamine in chicks[J]. Invest Ophthalmol Vis Sci, 2018, 59(11): 4413-4424.
[21]
Kinane C, Calligaro H, Jandot A, et al. Dopamine modulates the retinal clock through melanopsin-dependent regulation of cholinergic waves during development[J]. BMC Biol, 2023, 21(1): 146.
[22]
Tuling L, Bo B, Yixian H, et al. Suppressive effect of nitric oxide synthase (NOS) inhibitor L-NMMA acetate on choroidal fibrosis in experimental myopic guinea pigs through the nitric oxide signaling pathway[J]. Eur J Pharmacol, 2023, 960: 176111.
[23]
Nickla LD, Wallman J. The multifunctional choroid[J]. Prog Retin Eye Res, 2010, 29(2): 144-168.
[24]
Li Y, Liu C, Sun M, et al. Ocular safety evaluation of blue light scleral cross-linking in vivo in rhesus macaques[J]. Graefes Arch Clin Exp Ophthalmol, 2019, 257(7): 1435-1442.
[25]
Foulds WS, Barathi VA, Luu CD. Progressive myopia or hyperopia can be induced in chicks and reversed by manipulation of the chromaticity of ambient light[J]. Invest Ophthalmol Vis Sci, 2013, 54(13): 8004-8012.
[26]
Thakur S, Dhakal R, Verkicharla PK. Short-term exposure to blue light shows an inhibitory effect on axial elongation in human eyes independent of defocus[J]. Invest Ophthalmol Vis Sci, 2021, 62(15): 22.
[27]
Wang X, Sun Y, Wang K, et al. Effects of blue light exposure on ocular parameters and choroidal blood perfusion in Guinea pig[J]. Exp Eye Res, 2023, 235: 109619.
[28]
Chun RK, Choy KY, Li KK, et al. Additive effects of narrowband light and optical defocus on chick eye growth and refraction[J]. Eye Vis (Lond), 2023, 10(1): 15.
[29]
Yu M, Liu W, Wang B, et al. short wavelength (blue) light is protective for lens-induced myopia in guinea pigs potentially through a retinoic acid-related mechanism[J]. Invest Ophthalmol Vis Sci, 2021, 62(1): 21.
[30]
Tian T, Zou L, Wang S, et al. The role of dopamine in emmetropization modulated by wavelength and temporal frequency in guinea pigs[J]. Invest Ophthalmol Vis Sci, 2021, 62(12): 20.
[31]
Mutti DO, Mulvihill SP, Orr DJ, et al. The effect of refractive error on melanopsin-driven pupillary responses[J]. Invest Ophthalmol Vis Sci, 2020, 61(12): 22.
[32]
Wen Y, Dai B, Zhang X, et al. Retinal transcriptomics analysis reveals the underlying mechanism of disturbed emmetropization induced by wavelength defocus[J]. Curr Eye Res, 2022, 47(6): 908-917.
[33]
Chakraborty R, Park HN, Hanif AM, et al. ON pathway mutations increase susceptibility to form-deprivation myopia[J]. Exp Eye Res, 2015, 137: 79-83.
[34]
Wang M, Aleman AC, Schaeffel F. Probing the potency of artificial dynamic ON or OFF Stimuli to inhibit myopia development[J]. Invest Ophthalmol Vis Sci, 2019, 60(7): 2599-2611.
[35]
Schilling T, Amorim-de-Sousa A, A Wong N, et al. Increase in b-wave amplitude after light stimulation of the blind spot is positively correlated with the axial length of myopic individuals[J]. Sci Rep, 2022, 12(1): 4785.
[36]
Amorim-de-Sousa A, Schilling T, Fernandes P, et al. Blue light blind-spot stimulation upregulates b-wave and pattern ERG activity in myopes[J]. Sci Rep, 2021, 11(1): 9273.
[37]
Zhang C, Zhu Z, Zhao J, et al. Ubiquitous light-emitting diodes: potential threats to retinal circadian rhythms and refractive development[J]. Sci Total Environ, 2023, 862: 160809.
[38]
Bai WL, Wang MJ, Gan JH, et al. Circadian rhythm disruption induces myopia in mice[J]. Exp Eye Res, 2026, 264: 110823.
[39]
Chang AM, Aeschbach D, Duffy JF, et al. Evening use of light-emitting eReaders negatively affects sleep, circadian timing, and next-morning alertness[J]. Proc Natl Acad Sci U S A, 2015, 112(4): 1232-1237.
[40]
Cougnard-Gregoire A, Delcourt C. Response to the letter to the editor regarding " blue light exposure: ocular hazards and prevention-a narrative review" by iqbal et al. Ophthalmol Ther, 2023, 12(5): 2817-2819.
[41]
Cougnard-Gregoire A, Merle BMJ, Aslam T, et al. Blue light exposure: ocular hazards and prevention-a narrative review[J]. Ophthalmol Ther, 2023, 12(2): 755-788.
[42]
Krutmann J, Béhar-Cohen F, Baillet G, et al. Towards standardization of UV eye protection: what can be learned from photodermatology?[J]. Photodermatol Photoimmunol Photomed, 2014, 30(2-3): 128-136.
[43]
Torii H, Kurihara T, Seko Y, et al. Violet light exposure can be a preventive strategy against myopia progression[J]. EBioMedicine, 2017, 15: 210-219.
[44]
Mori K, Torii H, Hara Y, et al. Effect of violet light-transmitting eyeglasses on axial elongation in myopic children: a randomized controlled trial[J]. J Clin Med, 2021, 10(22): 5462.
[45]
Torii H, Ohnuma K, Kurihara T, et al. Violet light transmission is related to myopia progression in adult high myopia[J]. Sci Rep, 2017, 7(1): 14523.
[46]
Ofuji Y, Torii H, Yotsukura E, et al. Axial length shortening in a myopic child with anisometropic amblyopia after wearing violet light-transmitting eyeglasses for 2 years[J]. Am J Ophthalmol Case Rep, 2020, 20: 101002.
[47]
Torii H, Mori K, Okano T, et al. Short-Term Exposure to Violet Light Emitted from Eyeglass Frames in Myopic Children: A Randomized Pilot Clinical Trial[J]. J Clin Med, 2022, 11(20): 6000.
[48]
Jeong H, Kurihara T, Jiang X, et al. Suppressive effects of violet light transmission on myopia progression in a mouse model of lens-induced myopia[J]. Exp Eye Res, 2023, 228: 109414.
[49]
Nguyen MT, Vemaraju S, Nayak G, et al. An opsin 5-dopamine pathway mediates light-dependent vascular development in the eye[J]. Nat Cell Biol, 2019, 21(4): 420-429.
[50]
Strickland R, Landis EG, Pardue MT. Short-wavelength (violet) light protects mice from myopia through cone signaling[J]. Invest Ophthalmol Vis Sci, 2020, 61(2): 13.
[51]
Jia Y, Hu DN, Zhu D, et al. MMP-2, MMP-3, TIMP-1, TIMP-2, and TIMP-3 protein levels in human aqueous humor: relationship with axial length[J]. Invest Ophthalmol Vis Sci, 2014, 55(6): 3922-3928.
[52]
Zhao F, Zhou Q, Reinach PS, et al. Cause and effect relationship between changes in scleral matrix metallopeptidase-2 expression and myopia development in mice[J]. Am J Pathol, 2018, 188(8): 1754-1767.
[53]
Xiaotong L, Lingbo L, Yushan X, et al. Effects of riboflavin/ultraviolet-A scleral collagen cross-linking on regional scleral thickness and expression of MMP-2 and MT1-MMP in myopic guinea pigs[J]. PloS one, 2023, 18(1): e0279111-e0279111.
[54]
Hsiao YT, Lee JJ, Yang IH, et al. Ultraviolet A at levels experienced outdoors suppresses transforming growth factor-beta signaling and collagen production in human scleral fibroblasts[J]. Biochem Biophys Res Commun, 2023, 641: 10-17.
[55]
Kim ML, Sung KR, Kwon J, et al. Statins suppress TGF-β2-mediated MMP-2 and MMP-9 expression and activation through RhoA/ROCK inhibition in astrocytes of the human optic nerve head[J]. Invest Ophthalmol Vis Sci, 2020, 61(5): 29.
[56]
Buhr ED, Yue WW, Ren X, et al. Neuropsin (OPN5)-mediated photoentrainment of local circadian oscillators in mammalian retina and cornea[J]. Proc Natl Acad Sci U S A, 2015, 112(42): 13093-13098.
[57]
Ota W, Nakane Y, Hattar S, et al. Impaired circadian photoentrainment in opn5-null mice[J]. iScience, 2018, 6: 299-305.
[1] 顾陆恺淇, 吴思源, 柯碧莲. 短波长光在光-眼-脑轴中对近视眼与全身健康共同影响的研究进展[J/OL]. 中华眼科医学杂志(电子版), 2025, 15(06): 362-368.
[2] 潘星辰, 王宇辰, 周欣佐, 何奕璇, 楚文博, 韩镒泽, 郭安琪, 王岳鑫, 刘子源, 李学民. 高度近视眼患者静态及动态色觉特征的临床研究[J/OL]. 中华眼科医学杂志(电子版), 2025, 15(06): 340-344.
[3] 鲜昊城, 许珂, 代锦岳, 李学民. 高度近视眼合并开角型青光眼结构与血流参数诊断价值及联合诊断模型的临床研究[J/OL]. 中华眼科医学杂志(电子版), 2025, 15(06): 333-339.
[4] 罗怡凡, 杜永乐, 柯碧莲. 重视近视防控中风险预测、前沿技术整合及个体化诊疗策略的构建[J/OL]. 中华眼科医学杂志(电子版), 2025, 15(06): 321-326.
[5] 林炯文, 张铭志. 眼底影像人工智能技术在近视眼应用中的研究进展[J/OL]. 中华眼科医学杂志(电子版), 2025, 15(05): 304-308.
[6] 张华, 赵欣, 米金园, 刘啸昔, 张学斌, 闫诗语, 孙朝晖. 角膜断层地形图引导与像差优化准分子激光原位角膜磨镶术治疗近视眼散光术后1年高阶像差及客观视觉质量的临床研究[J/OL]. 中华眼科医学杂志(电子版), 2025, 15(05): 282-287.
[7] 胡沘, 秦晓, 肖峣, 田磊. 基于计算流体力学角膜表面空气脉冲压强分布特征的临床研究[J/OL]. 中华眼科医学杂志(电子版), 2025, 15(04): 199-205.
[8] 张英蕾, 石园方, 竺向佳. 重视高度近视眼合并白内障围手术期并发症[J/OL]. 中华眼科医学杂志(电子版), 2025, 15(04): 193-198.
[9] 高雄伟, 王峰, 牛丽霞. 胎盘生长因子与近视眼激光术后妊娠期女性角膜生物学特征关系的临床研究[J/OL]. 中华眼科医学杂志(电子版), 2025, 15(01): 33-39.
[10] 李文涛, 赵峰, 陈彦霓, 文勇强, 魏丽云, 张润妹, 赵敏, 杨子颖, 廖锐. 模拟户外光照的全光谱动态光源对豚鼠眼屈光发育影响的实验研究[J/OL]. 中华眼科医学杂志(电子版), 2025, 15(01): 27-32.
[11] 康梦田, 包陈颖, 宋芊芊, 李婧, 郑燕, 李仕明, 翟长斌, 王宁利. 近视眼屈光手术患者术后预期和依从性的流行学病学研究[J/OL]. 中华眼科医学杂志(电子版), 2025, 15(01): 40-44.
[12] 郑燕, 翟长斌, 付彩云, 张丽, 王玥, 胡雅斌, 柳静. 准分子激光原位角膜磨镶术联合快速角膜交联术后角膜光密度变化的临床研究[J/OL]. 中华眼科医学杂志(电子版), 2024, 14(06): 327-334.
[13] 陆妍, 王浩, 王开琦, 叶强, 张文芳. 甘肃省武威市民勤县小学生视力不良及近视现状的流行病学研究[J/OL]. 中华眼科医学杂志(电子版), 2024, 14(03): 140-145.
[14] 顾一帆, 潘璐. 关注近视眼防控措施及其面临的形势[J/OL]. 中华眼科医学杂志(电子版), 2024, 14(03): 129-133.
[15] 李新星, 方晏红, 陈会振, 张蓝月, 刘涵. 维生素D与眼病关系的研究进展[J/OL]. 中华眼科医学杂志(电子版), 2023, 13(06): 366-370.
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?