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中华眼科医学杂志(电子版) ›› 2023, Vol. 13 ›› Issue (06) : 366 -370. doi: 10.3877/cma.j.issn.2095-2007.2023.06.009

综述

维生素D与眼病关系的研究进展
李新星1, 方晏红1, 陈会振1, 张蓝月1, 刘涵1,()   
  1. 1. 402260 重庆大学附属江津医院眼科
  • 收稿日期:2023-11-25 出版日期:2023-12-28
  • 通信作者: 刘涵
  • 基金资助:
    2020年重庆市自然科学基金项目(cstc2020jcyj-msxmX0698); 2023年重庆市自然科学基金项目(CSTB2023NSCQ-MSX0639); 2023年重庆市江津区科学技术局项目(Y2023016)

Advances on the vitamin D and ocular disease

Xinxing Li1, Yanhong Fang1, Huinzhen Chen1, Lanyue Zhang1, Han Liu1,()   

  1. 1. Department of Ophthalmology, Jiangjin Hospital affiliated to Chongqing University, Chongqing 402260, China
  • Received:2023-11-25 Published:2023-12-28
  • Corresponding author: Han Liu
引用本文:

李新星, 方晏红, 陈会振, 张蓝月, 刘涵. 维生素D与眼病关系的研究进展[J]. 中华眼科医学杂志(电子版), 2023, 13(06): 366-370.

Xinxing Li, Yanhong Fang, Huinzhen Chen, Lanyue Zhang, Han Liu. Advances on the vitamin D and ocular disease[J]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2023, 13(06): 366-370.

维生素D是一种类固醇激素,在生理学中具有多种作用,包括维持钙稳态、调节免疫、促进细胞分化和增殖。维生素D在干眼、糖尿病视网膜病变(DR)及甲状腺相关性眼病中的作用已经得到了广泛证实。既往研究结果表明,维生素D与包括近视眼、年龄相关性黄斑变性(AMD)、青光眼、DR、干眼、甲状腺相关性眼病,葡萄膜炎、视网膜母细胞瘤及白内障等眼病疾病均相关。本文中笔者从维生素D代谢角度探讨维生素D与眼病疾病的相关性,旨在为眼部疾病诊治提供新思路。

Vitamin D is a steroid hormone that has widespread role in human physiology, not only in the maintenance of calcium homeostasis but also in immunomodulation, cellular differentiation, and proliferation. The role of vitamin D in ocular surface conditions such as dry eye disease, diabetic retinopathy, and thyroid eye disease has received widespread and well deserved attention. It has been demonstrated that vitamin D has associated with eye diseases including myopia, age-related macular degeneration (AMD), glaucoma, DR, dry eye, thyroid related eye diseases, uveitis, retinoblastoma, and cataracts. The correlation between vitamin D and eye diseases from the perspective of vitamin D metabolism was reviewed, aiming to provide new ideas for the diagnosis and treatment of eye diseases.

图1 维生素D的来源和代谢
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