切换至 "中华医学电子期刊资源库"

中华眼科医学杂志(电子版) ›› 2023, Vol. 13 ›› Issue (06) : 366 -370. doi: 10.3877/cma.j.issn.2095-2007.2023.06.009

综述

维生素D与眼病关系的研究进展
李新星1, 方晏红1, 陈会振1, 张蓝月1, 刘涵1,()   
  1. 1. 402260 重庆大学附属江津医院眼科
  • 收稿日期:2023-11-25 出版日期:2023-12-28
  • 通信作者: 刘涵
  • 基金资助:
    2020年重庆市自然科学基金项目(cstc2020jcyj-msxmX0698); 2023年重庆市自然科学基金项目(CSTB2023NSCQ-MSX0639); 2023年重庆市江津区科学技术局项目(Y2023016)

Advances on the vitamin D and ocular disease

Xinxing Li1, Yanhong Fang1, Huinzhen Chen1, Lanyue Zhang1, Han Liu1,()   

  1. 1. Department of Ophthalmology, Jiangjin Hospital affiliated to Chongqing University, Chongqing 402260, China
  • Received:2023-11-25 Published:2023-12-28
  • Corresponding author: Han Liu
引用本文:

李新星, 方晏红, 陈会振, 张蓝月, 刘涵. 维生素D与眼病关系的研究进展[J/OL]. 中华眼科医学杂志(电子版), 2023, 13(06): 366-370.

Xinxing Li, Yanhong Fang, Huinzhen Chen, Lanyue Zhang, Han Liu. Advances on the vitamin D and ocular disease[J/OL]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2023, 13(06): 366-370.

维生素D是一种类固醇激素,在生理学中具有多种作用,包括维持钙稳态、调节免疫、促进细胞分化和增殖。维生素D在干眼、糖尿病视网膜病变(DR)及甲状腺相关性眼病中的作用已经得到了广泛证实。既往研究结果表明,维生素D与包括近视眼、年龄相关性黄斑变性(AMD)、青光眼、DR、干眼、甲状腺相关性眼病,葡萄膜炎、视网膜母细胞瘤及白内障等眼病疾病均相关。本文中笔者从维生素D代谢角度探讨维生素D与眼病疾病的相关性,旨在为眼部疾病诊治提供新思路。

Vitamin D is a steroid hormone that has widespread role in human physiology, not only in the maintenance of calcium homeostasis but also in immunomodulation, cellular differentiation, and proliferation. The role of vitamin D in ocular surface conditions such as dry eye disease, diabetic retinopathy, and thyroid eye disease has received widespread and well deserved attention. It has been demonstrated that vitamin D has associated with eye diseases including myopia, age-related macular degeneration (AMD), glaucoma, DR, dry eye, thyroid related eye diseases, uveitis, retinoblastoma, and cataracts. The correlation between vitamin D and eye diseases from the perspective of vitamin D metabolism was reviewed, aiming to provide new ideas for the diagnosis and treatment of eye diseases.

图1 维生素D的来源和代谢
[1]
Valle MS, Russo C, Malaguarnera L. Protective role of vitamin D against oxidative stress in diabetic retinopathy[J]. Diabetes Metab Res Rev, 2021, 37(8): e3447.
[2]
Cojic M, Kocic R, Klisic A, et al. The effects of vitamin d supplementation on metabolic and oxidative stress markers in patients with type 2 diabetes: a 6 month follow up randomized controlled study [J]. Front Endocrinol, 2021, 12: 610893.
[3]
Sharif AF, Hafezi S, Sharif AN, et al. Vitamin D modulates systemic inflammation in patients with severe COVID-19[J]. Life Sci, 2022, 307: 120909.
[4]
Alsalem JA, Patel D, Susarla R, et al. Characterization of vitamin D production by human ocular barrier cells[J]. Invest Ophthalmol Vis Sci, 2014, 55(4): 2140-2147.
[5]
Rullo J, Pennimpede T, Mehraban FP, et al. Intraocular calcidiol: Uncovering a role for vitamin D in the eye[J]. J Steroid Biochem Mol Biol, 2020, 197(C): 105536.
[6]
Lee JH, Kim SJ, Byun YS, et al. The association of serum vitamin d level with the severity of dry eye parameters in primary Sjogren syndrome[J]. Cornea, 2020, 39(39): 702-705.
[7]
Fukuoka S, Arita R, Mizoguchi T, rt al. Relation of dietary fatty acids and vitamin d to the prevalence of meibomian gland dysfunction in Japanese adults: The Hirado-Takushima Study[J]. J Clinical Med, 2021, 10(2): 350.
[8]
Arman A, Petricli IS, Kara C, et al. The relationship between serum vitamin D levels and dry eye syndrome in postmenopausal women[J]. Ann Clin Anal Med, 2020, 11: 91-94.
[9]
Eslampoor A, Najjaran M, Arjmand-Askari E, et al. Effect of oral vitamin D supplementation on dry eye disease patients with vitamin D deficiency[J]. Clin Exp Optom, 2022, 106(3): 1-6.
[10]
Watts P, Sahai A, Kumar PR, et al. A prospective study to assess the role of vitamin D individually and in combination with cyclosporine in the treatment of dry eye in patients with deficient serum 25(OH)D levels[J]. Indian J Ophthalmol, 2020, 68(6): 1020-1026.
[11]
张丽娟,梁荣斌,邵毅.维生素D缺乏与干眼关系的研究进展[J].眼科新进展202141(8):794-796,800.
[12]
Eksioglu U, Atilgan HI, Yakin M, et al. Antioxidant effects of vitamin D on lacrimal glands against high dose radioiodine-associated damage in an animal model[J].Cutan Ocul Toxicol, 2019, 38(1) : 18-24.
[13]
Bascom A, Redfern RL, Reins RY. Characterization of vitamin D levels in ocular surface tissues and their association with dry eye disease[J]. Investig Ophthalmol Vis Sci, 2019, 60: 1414.
[14]
Nadri G, Saxena S, Kaur A, et al. Correlation between vitamin D serum levels and severity of diabetic retinopathy in patients with type 2 diabetes mellitus[J]. J. Endocrino Metab Diabetes South Afr, 2021, 26(3): 82-88.
[15]
Castillo-Oti JM, Galvan-Manso AI, Callejas-Herrero MR, et al. Vitamin D deficiency is significantly associated with retinopathy in type 2 diabetes mellitus: A Case-Control Study[J]. Nutrients, 2021, 14(1): 84.
[16]
Tomic M, Vrabec R, Ljubic S, et al. Plasma homocysteine is associated with nonproliferative retinopathy in patients with type 2 diabetes without renal disease[J]. Diabetes Metab Syndr, 2022, 16(1): 102355.
[17]
Girard E, Nacher M, Bukasa-Kakamba J, et al. Vitamin D deficiency in patients with diabetes in french guiana: epidemiology and relation with microvascular and macrovascular complications[J]. Nutrients, 2021, 13(12): 4302.
[18]
Xiao Y, Wei L, Xiong X, et al. Association between vitamin d status and diabetic complications in patients with type 2 diabetes mellitus: a cross-sectional study in Hunan China[J]. Front Endocrinol, 2020, 11: 564738.
[19]
Merrigan SL, Park B, Ali Z, et al. Calcitriol and non-calcemic vitamin D analogue, 22-oxacalcitriol, attenuate developmental and pathological choroidal vasculature angiogenesis ex vivo and in vivo[J]. Oncotarget, 2020, 11(5): 493-509.
[20]
Tohari AM, Almarhoun M, Alhasani RH, et al. Protection by vitamin D against high-glucose-induced damage in retinal pigment epithelial cells[J]. Exp Cell Res, 2020, 392(1): 112023.
[21]
Jung BJ, Jee D. Association between serum 25-hydroxyvitamin D levels and myopia in general Korean adults[J]. Indian J Ophthalmol, 2020, 68(1): 15-22.
[22]
Gao F, Li P, Liu YQ, et al. Association study of the serum 25(OH)D concentration and myopia in Chinese children[J]. Medicine, 2021, 100(26): e26570.
[23]
Specht IO, Jacobsen N, Frederiksen P, et al. Neonatal vitamin D status and myopia in young adult men[J]. Acta Ophthalmol, 2020, 98(5): 500-505.
[24]
Harb EN, Wildsoet CF. Nutritional factors and myopia: an analysis of national health and nutrition examination survey data[J]. Optom Vis Sci, 2021, 98(5): 458-468.
[25]
Chou HD, Yao TC, Huang YS, et al. Myopia in school-aged children with preterm birth: The roles of time spent outdoors and serum vitamin D[J]. Br J Ophthalmol, 2021, 105(4): 468-472.
[26]
Lingham G, Mackey DA, Zhu K, et al. Time spent outdoors through childhood and adolescence-assessed by 25-hydroxyvitamin D concentration-and risk of myopia at 20 years[J]. Acta Ophthalmol, 2021, 99(6): 679-687.
[27]
Tang SM, Lau T, Rong SS, et al. Vitamin D and its pathway genes in myopia: Systematic review and meta-analysis[J]. Br J Ophthalmol, 2019, 103(1): 8-17.
[28]
Hashemi R, Bandarian M, Abedi-Taleb E, et al. The association between blood vitamins D and E with age-related macular degeneration: A pilot study[J]. Interv Med Appl Sci, 2018, 10(3): 127-132.
[29]
Malaguarnera L . Vitamin D and microbiota: Two sides of the same coin in the immunomodulatory aspects [J]. Int Immunopharmacol, 2020, 79: 106112.
[30]
Mahgoub MY, Abou Ghanima AT, Elmohamady MN, et al. Age-Related Macular Degeneration in Primary Osteoarthritis Egyptian Patients[J]. Open Access Rheumatol, 2020, 12, 35-40.
[31]
Christen WG, Cook NR, Manson JE, et al. Effect of vitamin d and omega-3 fatty acid supplementation on risk of age-related macular degeneration: an ancillary study of the VITAL randomized clinical trial[J]. Jama Ophthalmol, 2020, 138: 1280-1289.
[32]
Ayyagari R, Chen YI, Zangwill LM, et al. Association of severity of primary open-angle glaucoma with serum vitamin D levels in patients of African descent[J]. Mol Vis, 2019, 25: 438-445.
[33]
Dikci S, Ozturk E, Firat PG, et al. The Association of serum Vitamin D levels with pseudoexfoliation glaucoma/syndrome[J]. Endocr Metab Immune Disord Drug Targets, 2019, 19(2): 166-170.
[34]
Carbone LD, Johnson K, Larson JC, et al. Association of vitamin D with incident glaucoma: Findings from the Women's Health Initiative[J]. J Investig Med, 2021, 69: 843-850.
[35]
Cho Y, Yun SP, Yoo WS, et al. Reduced 25-hydroxyvitamin D concentration in the aqueous humor f cataract patients with open-angle glaucoma[J]. Sci Rep, 2021, 11(1): 18785.
[36]
Kocaturk T, Bekmez S, Unubol M. Effects of vitamin D deficiency on intraocular pressure values obtained by ocular response nalyzer[J]. Int Ophthalmol, 2020, 40(3): 697-701.
[37]
Lv Y, Yao Q, Ma W, et al. Associations of vitamin D deficiency and vitamin D receptor (Cdx-2, Fok I, Bsm I and Taq I) polymorphisms with the risk of primary open-angle glaucoma[J].BMC Ophthalmol, 2016, 16: 116.
[38]
梁健,张振,曾怡. Graves眼病患者血清中性粒细胞计数、CRP、ESR、NLR及甲状腺自身抗体的表达和意义[J]. 河北医药202345(11):1707-1709.
[39]
Sadaka A, Nguyen K, Malik A, et al. Vitamin D and selenium in a thyroid eye disease population in Texas[J]. Neuroophthalmology, 2019, 43(5): 291-294.
[40]
Heisel CJ, Riddering AL, Andrews CA, et al. Serum vitamin D deficiency is an independent risk factor for thyroid eye disease[J]. Ophthalmic Plast Reconstr Surg, 2020, 36(1): 17-20.
[41]
赵长英,甘西伦,王明霜,等.维生素D缺乏与Graves病及其并发症关系的临床研究[J].重庆医科大学学报201843(6):814-817.
[42]
Llop SM, Davoudi S, Stanwyck LK, et al. Association of low vitamin d levels with noninfectious uveitis and scleritis[J]. Ocul Immunol Inflamm, 2019, 27(4): 602-609.
[43]
Rohmer J, Hadjadj J, Bouzerara A, et al. Serum 1, 25(OH)2 vitamin d and 25(OH) vitamin d ratio for the diagnosis of sarcoidosis-related uveitis[J]. Ocul Immunol Inflamm, 2020, 28(3): 341-347.
[44]
Chiu ZK, Lim LL, Rogers SL, et al. Patterns of vitamin D levels and exposures in active and inactive noninfectious uveitis patients[J]. Ophthalmology, 2020, 127(2): 230-237.
[45]
Pillar S, Amer R. The association between vitamin D and uveitis: A comprehensive review[J]. Surv Ophthalmol, 2021, 67(2): 321-330.
[46]
魏亚萍,褚兆苹,王蓓. 维生素D与肿瘤发生风险的系统评价[J]. 肿瘤代谢与营养电子杂志202310(1):29-36.
[47]
Schündeln MM, Hauffa PK, Bauer JJ, et al. Pediatric survivors of retinoblastoma are at risk for altered bone metabolism after chemotherapy treatment early in life[J]. Pediatr Hematol Oncol, 2015, 32(7): 455-466, 269.
[48]
Mejia-Rodriguez F, Flores-Aldana ME, Quezada-Sanchez AD, et al. Association between predictors of vitamin d serum levels and risk of retinoblastoma in children: A case-control study[J]. Nutrients, 2021, 13(8): 2510.
[49]
Orjuela-Grimm M, Carreno SB, Liu X, et al. Sunlight exposure in infancy decreases risk of sporadic retinoblastoma, extent of intraocular disease[J]. Cancer Rep, 2021, 4(6): e1409.
[50]
陈晓娟,张国伟,李鹏飞,等. 紫外线照射后人晶状体上皮细胞的iTRAQ定量蛋白质组学研究 [J]. 国际眼科杂志202323(4):551-556.
[51]
刘兵. 大鼠血清25羟维生素D水平与年龄相关性白内障的关系 [J]. 安徽医药201923(9):1728-1732.
[52]
Oktem C, Aslan F. Vitamin D levels in young adult cataract patients: a case-control study[J]. Ophthalmic Res, 2021, 64: 116-120.
[53]
朱跃弟,姚琨,姚蕊莲. 中老年人血清25-羟基维生素D水平与老年性白内障发生的相关性分析[J]. 眼科新进展201939(7):686-689.
[54]
Sorkhabi R, Ahoor MH, Ghorbanihaghjo A, et al. Serum vitamin D levels in patients with vernal keratoconjunctivitis and its relationship with disease severity[J]. Eur J Ophthalmol, 2021, 31(6): 3259-3264.
[55]
Aslan MG, Findik H, Okutucu M, et al. Serum 25-Hydroxy Vitamin D, Vitamin B12, and folic acid levels in progressive and nonprogressive keratoconus[J]. Cornea, 2021, 40: 334-341.
[1] 王叶青, 李利彤, 李伟绪, 曹猛. 牙周炎和糖尿病视网膜病变的因果关系:一项双向两样本孟德尔随机化分析[J/OL]. 中华口腔医学研究杂志(电子版), 2024, 18(03): 160-168.
[2] 张秋子, 胡利梅, 陈雅茹, 左丽, 任卫东. 维生素D水平与亚急性甲状腺炎预后的相关性研究[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(02): 217-219.
[3] 白若靖, 郭军. 维生素D对肺部疾病临床意义的研究进展[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(04): 659-662.
[4] 暴静, 吴霞, 田雅萍, 尹钢. 维生素D3联合孟鲁司特钠治疗支气管哮喘对血清VEGF、TGF-β1及肺功能的影响[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(01): 63-67.
[5] 刘思含, 张静. 老年人血清铁与C 反应蛋白的比值及25-羟基维生素D3 与肾功能受损的关系研究[J/OL]. 中华肾病研究电子杂志, 2024, 13(05): 268-272.
[6] 汪毅仁, 江晓丹, 李佳曦, 赵天瑶, 李学民. 干眼的症状、体征与焦虑及抑郁相关性的临床研究[J/OL]. 中华眼科医学杂志(电子版), 2024, 14(04): 212-216.
[7] 张阳, 罗莎莎, 邹文军. 年龄相关性黄斑变性分子机制的研究进展[J/OL]. 中华眼科医学杂志(电子版), 2024, 14(04): 240-246.
[8] 罗桂彬, 沈强, 张蓝月, 刘涵. 晚期糖化终末产物与糖尿病视网膜病变相关性的研究进展[J/OL]. 中华眼科医学杂志(电子版), 2024, 14(04): 247-251.
[9] 顾一帆, 潘璐. 关注近视眼防控措施及其面临的形势[J/OL]. 中华眼科医学杂志(电子版), 2024, 14(03): 129-133.
[10] 陆妍, 王浩, 王开琦, 叶强, 张文芳. 甘肃省武威市民勤县小学生视力不良及近视现状的流行病学研究[J/OL]. 中华眼科医学杂志(电子版), 2024, 14(03): 140-145.
[11] 刘涵, 张蓝月, 沈强. 眼表重建技术的研究进展[J/OL]. 中华眼科医学杂志(电子版), 2024, 14(03): 182-186.
[12] 张涛, 汪建茹, 赵瑾超, 葛程, 钱竹韵, 陶勇. 基质金属蛋白酶9即时检测对干眼诊断效能分析的临床研究[J/OL]. 中华眼科医学杂志(电子版), 2024, 14(01): 14-19.
[13] 房桂彬, 肖进, 傅光涛, 郑秋坚. 老年髋部骨折患者术后1年行走能力的影响因素分析[J/OL]. 中华老年骨科与康复电子杂志, 2024, 10(05): 273-280.
[14] 韩俊岭, 王刚, 马厉英, 连颖, 徐慧. 维生素D 联合匹维溴铵治疗腹泻型肠易激综合征患者疗效及对肠道屏障功能指标的影响研究[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(06): 560-564.
[15] 周佳佳, 俞莹, 梁舒. 视频终端视相关性干眼症的机制研究进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(04): 402-406.
阅读次数
全文


摘要