Advances on the neurodegeneration of visual pathway in glaucoma and the role of demyelination in glaucomatous optic neuropathy

doi:10.3877/cma.j.issn.2095-2007.2024.04.008

Abstract

Abstract:

Glaucoma is a disease characterized by narrowing of the optic disc edge and visual field damage caused by various factors leading to optic nerve damage.Glaucoma nerve damage not only affects retinal ganglion cells，but also involves extensive neurodegenerative changes in the visual pathway and central nervous system.Glaucoma has similar pathological changes to other central nervous system diseases such as multiple sclerosis，and demyelination changes are involved in the pathological process of glaucoma nerve damage.Therefore，studying the mechanism of demyelination and remyelination function，promoting myelin formation and remyelination，and finding new treatment pathways for glaucoma from the perspective of neuroprotective strategies are of great significance.

Key words: Glaucoma, Demyelination, Nerve axon, Neurodegeneration, Remyelination

Li Zhang, Yingdi Fu, Ningli Wang, Xiaoling Zuo. Advances on the neurodegeneration of visual pathway in glaucoma and the role of demyelination in glaucomatous optic neuropathy[J]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2024, 14(04): 233-239.

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