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Chinese Journal of Ophthalmologic Medicine(Electronic Edition) ›› 2024, Vol. 14 ›› Issue (04): 247-251. doi: 10.3877/cma.j.issn.2095-2007.2024.04.010

• Review • Previous Articles     Next Articles

The advances on the correlation between advanced glycation end-products and diabetic retinopathy

Guibin Luo1, Qiang Shen1, Lanyue Zhang1, Han Liu1,()   

  1. 1.Department of Ophthalmology,Chongqing University Jiangjin Hospital,Chongqing 402260,China
  • Received:2024-07-24 Online:2024-08-28 Published:2025-01-14
  • Contact: Han Liu

Abstract:

Diabetes causes diabetic retinopathy(DR),which is an important cause of blindness and low vision in adults.Advanced glycation end products(AGE)are molecules produced by non enzymatic modification of large molecules such as proteins,lipids,and nucleic acids through translation by glucose or other sugars.Binding of AGE to the receptor for advanced glycosylation end products(RAGE)can produce a series of pathological mechanisms,which are important factors involved in the occurrence and progression of DR.AGE inhibitors,AGE blockers,and RAGE inhibitors are potential therapeutic targets for DR in the future.The correlation between AGE and DR was reviewed in this paper,aiming to provide insights for the diagnosis and treatment of DR.

Key words: Diabetes mellitus, Diabetic retinopathy, Advanced glycation end product, Receptor for advanced glycation end-products

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