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Chinese Journal of Ophthalmologic Medicine(Electronic Edition) ›› 2023, Vol. 13 ›› Issue (02): 104-108. doi: 10.3877/cma.j.issn.2095-2007.2023.02.008

• Review • Previous Articles     Next Articles

Research progress of Janus kinase inhibitor in the treatment of Juvenile idiopathic arthritis associated uveitis

Chongyang She, Hong Lu()   

  1. Department of Ophtalmology, Beijing Chao Yang Hospital, Capital Medical University, Beijing 10020, China
  • Received:2022-03-15 Online:2023-04-28 Published:2023-08-14
  • Contact: Hong Lu

Abstract:

Juvenile idiopathic arthritis-associated uveitis (JIA-U) is a common uveitis in children, and its complications can eventually lead to visual impairment and blindness. At present, traditional treatment methods and targeted therapies have been widely used in JIA-U, which has better effect. However, there are still some patients who cannot achieve inflammation control and remission. Janus kinase (JAK) is the effector pathway of many inflammatory factors, and JAK inhibitors (JAKinibs) are also widely used in the treatment of some other immune-related diseases. Compared with other biological agents, JAKinibs is a small molecule substance that can be delivered orally, which is a more convenient medication method. The application of JAKinibs is similar to other types of targeted therapies, which is of great benifit to relieve with continuous hormone-free and a better prognosis. However, there are currently no relevant guidelines for the treatment of JIA-U using JAKinibs. Further understanding of the mechanism, clinical application and side effects of JAKinibs in treatment of JIA-U might is of great significance for popularizing the application of JAKinibs and developping general application guidelines.

Key words: Junior idiopathic arthritis associated uveitis, Janus kinase inhibitors, Clinical application

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