Advances on the mechanism of glaucoma filtration surgery scarring and anti-scarring treatment

doi:10.3877/cma.j.issn.2095-2007.2021.03.011

Abstract

Abstract:

Glaucoma has become the leading cause of irreversible blindness in the world. The pathological increase in intraocular pressure is one of the most dangerous factor leading glaucoma, which would cause characteristic optic nerve damage. In the past 50 years, glaucoma filtering surgery has been the primary treatment for reducing glaucoma intraocular pressure. Glaucoma filtering surgery often scares the filtering bleb after the operation, which obstructing the outflow of aqueous humor through the filtering channel, causing the function to fail. To clarify, the anti-scarring mechanism after glaucoma filtering operation is essential for the treatment of glaucoma. Therefore, the research on scar formation signal pathways worldwide and the current anti-scarring treatment methods were reviewed in this paper, aiming to provide new ideas for improving surgery outcome and the development of new clinical drugs.

Key words: Glaucoma, Fibroblast, Filter bleb, Anti-scarring

Mingshen Ma, Ying Shen, Wenxuan Li, Wenying Guan, Xin Kang, Haixia Zhao. Advances on the mechanism of glaucoma filtration surgery scarring and anti-scarring treatment[J]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2021, 11(03): 188-192.

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第一作者	输送系统	实验类别	作用机制	实验效果
Bulter等^[53]	纳米银粒子	动物实验	减少组织间胶原沉积并抑制成纤维细胞增殖	较丝裂霉素-C阳性对照组更为显著
Qiao等^[54]	光敏叠氮羟乙基壳聚糖水凝胶	动物实验	良好的水溶性及生物相容性	延长滤过通道的有效存在时间
Fili等^[55]	Ologen植入物	临床实验	良好的生物相容性	降低术后不良并发症的发生率
Ponnusamy等^[56]	聚乳酸-乙醇酸多孔图层	细胞及动物实验	通过药物缓释作用持续抗瘢痕化	减少术后组织纤维化，提高手术成功率

第一作者	输送系统	实验类别	作用机制	实验效果
Bulter等^[53]	纳米银粒子	动物实验	减少组织间胶原沉积并抑制成纤维细胞增殖	较丝裂霉素-C阳性对照组更为显著
Qiao等^[54]	光敏叠氮羟乙基壳聚糖水凝胶	动物实验	良好的水溶性及生物相容性	延长滤过通道的有效存在时间
Fili等^[55]	Ologen植入物	临床实验	良好的生物相容性	降低术后不良并发症的发生率
Ponnusamy等^[56]	聚乳酸-乙醇酸多孔图层	细胞及动物实验	通过药物缓释作用持续抗瘢痕化	减少术后组织纤维化，提高手术成功率

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