The aim of this study was to discuss the clinical effect of Leizhu McAb combined with laser in treating ischemic central retinal vein occlusion.

The case of 70 patients (72 eyes) with ischemic central retinal vein occlusion in Special Examination Department of Ophthalmology of Linfen Yaodu District Eye Hospital, Shanxi Province from September 2015 to September 2019 were collected. There were 36 males (36 eyes) and 34 females (36 eyes); they were aged 44 to 87 years-old with the average age (64.1±12.2) years-old. Intraluinal injection of Leizhu Mcab and multi-wavelength laser therapy was performed. The preoperative and postoperative vision, nerve fiber layer thickness of macular fovea, fluorescein fundus angiography, coherent optical tomography and the occurrence of complications for 1 week, 1 month, 3 months, and 6 months were examined and collected . Patient′s vision was described by the number of eyes and percentage and compared by the generalized linear mixed effect model. Thickness of retinal fiber layer in macular fovea was expressed as mean±standard deviation deviation and compared by ANOVA.

There were 47 eyes, accouting for 65.28% in patients with preoperative visual acuity<0.1; 11 eyes, accouting for 15.28% in patients with preoperative visual acuity≥0.1 and < 0.2; 11 eyes, accouting for 15.28% in patients with preoperative visual acuity≥0.2 and <0.3; 1 eyes, accouting for 1.39% in patients with preoperative visual acuity ≥0.3 and <0.4; 1 eyes, accouting for 1.39% in patients with preoperative visual acuity ≥0.5. The visual acuity improved gradually at each time point. After the analyzation of model of generalized linear mixing effect, the differences at each time point were statistically significant (χ²=8.31, P<0.05). Further pairwise comparison, there were differences between each time point before and after operation (χ²=12.39, 10.24, 14.26, 11.78; P<0.05). The thickness of macular fovea was 1 week, 1 month, 3 months and 6 months (715.57±213.18)μm, (303.03±66.03)μm, (300.83±63.68)μm, (258.71±39.02)μm and (243.43±47.51)μm, respectively. The thickness of macular fovea varied with time. After the analyzation of one-way ANOVA, the differences at each time point were statistically significant (F=206.89, P<0.05). Further pairwise comparisons the differences between 1 week, 1 month, 3 months and 6 months were statistically significant (t=21.29, 21.36, 23.50, 24.19; P<0.05). The differences between 3 months and 6 months after operation were statistically significant compared with that of 1 week after operation(t=2.26, 3.00; P<0.05); compared with that of 1 month after operation (t=2.17, 2.90; P<0.05). Of the 70 patients, 3 cases accouting for 4.29% had localized subconjunctival hemorrhage. 5 cases accouting for 7.14% had mild increase in intraocular pressure. The inflammation, neovascular glaucoma, retinal detachment and other complications were not found in all patients.

Patients with ischemic type CRVO were treated with intraluminal injection of Leizhu McAb and multi-wavelength laser therapy, which was valid for the first week and had the significant improvement after 3 months. Based on these, the treatment of ischemic type CRVO by the use of intraluminal injection of Leizhu McAb (once a month for 3 consecutive months) combined with multi-wavelength laser had an accurate curative effect, high safety, which is useful for clinical practice.