Study on the relationship among high molecular weight adiponectin, tumor necrosis factor-&#x03B1; and vascular endothelial growth factor with diabetic retinopathy

doi:10.3877/cma.j.issn.2095-2007.2017.04.003

Abstract

Abstract:

Objective

To discuss the relationship among high molecular weight adiponectin (HMW-ADP), tumor necrosis factor(TNF)-α and vascular endothelial growth factor(VEGF) with diabetic retinopathy(DR).

Methods

150 cases with type 2 diabetes mellitus from January to December 2014 were selected as study objects, 50 cases with NDR, 50 cases with NPDR and 50 cases with PDR. 50 cases for physical examination were selected as control group. Compared with the gender, history of hypertension and diabetes family history of χ²test. The clinical data such as HMW-ADP, TNF-α, VEGF, biochemical indexes and body mass index were all expressed by mean and standard deviation (±s), and compared by single factor analysis of variance. The effects of HMW-ADP, TNF-α, VEGF and other factors on NPDR and PDR were analyzed by multiple Logistic regression. The correlation of HMW-ADP, TNF-α and VEGF with DR was analyzed by Pearson correlation.

Results

The age of the NPDR group and the PDR group were larger than that of the NDR group and the control group (F=5.329, P<0.05). The history of hypertension in group NDR, group NPDR and group PDR were significantly higher than that of control group (χ²=20.215, P<0.05). The patients in group PDR had the longest course, followed by group NPDR, and the group NDR was the shortest (F=96.434, P<0.05). Fasting blood glucose in patients in group NDR, group NPDR and group PDR were significantly higher than that of control group (F=12.510, P<0.05). The fasting insulin levels in group PDR were the highest, followed by group NPDR and group NDR, and lowest in the control group (F=25.305, P<0.05). The content of triglyceride (TG) in patients in group NDR, group NPDR and group PDR were significantly higher than that of control group (F=16.419, P<0.05). The content of high-density lipoprotein cholesterol (HDL-C) was significantly lower than that of the control group (F=4.259, P<0.05). The creatinine of group NPDR and group PDR was significantly higher than that of control group (F=47.158, P<0.05). The difference between the two groups was statistically significant. The level of HMW-ADP in the NPDR group and the PDR group were significantly lower than that in the control group and the NDR group, and the NDR group was significantly lower than that of the control group, the difference between the two groups was statistically significant (F=362.480, P<0.05). The levels of TNF-α and VEGF in group PDR were the highest, followed by NPDR group; NDR group and control group were lowest, the difference between the two groups were statistically significant (F=239.200, 641.970; P<0.05). Multivariate analysis showed that age, duration of disease, TNF-α and VEGF were independent risk factors for NPDR (χ²=7.621, 18.331, 5.532, 5.618; P<0.05), and they were also independent risk factors for PDR (χ²=6.962, 11.542, 5.615, 5.331; P<0.05). HDL-C and HMW-ADP were protective factors for NPDR (χ²=6.694, 10.671; P<0.05), and they were also protective factors for PDR (χ²=5.674, 7.671; P<0.05). The levels of HMW-ADP in patients with DR were negatively correlated with TNF-α and VEGF (r=-0.328, -0.810; P<0.05).

Conclusion

In patients with DR, the level of HMW-ADP decreases, and the levels of TNF-α and VEGF increase; Multivariate analysis shows that HMW-ADP is protective factor, and TNF-α and VEGF are risk factor; HMW-ADP is negatively correlated with TNF-α and VEGF.

Key words: High molecular weight adiponectin, Tumor necrosis factor-α, Vascular endothelial growth factor, Diabetic retinopathy

Pei Yan, Li Zhang, Xiaohong Zhang, Yankun Zhang. Study on the relationship among high molecular weight adiponectin, tumor necrosis factor-α and vascular endothelial growth factor with diabetic retinopathy[J]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2017, 07(04): 158-164.

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Figures/Tables 6

References 57

[1]	李秀伦，龙文莉. 2型非增殖性糖尿病视网膜病变的影响因素分析[J]. 中国当代医药，2016,23(9):12-14.
[2]	潘爱平，杨云霞，徐洪磊. 2型糖尿病视网膜病变患者血清脂联素与VEGF水平的变化及意义[J]. 临床输血与检验，2017,19(2):170-172.
[3]	李芸云，刘宁朴. 脂联素与糖尿病视网膜病变相关性研究现状[J]. 中华眼底病杂志，2017,33(3):311-316.
[4]	李若琳，陈楠. 血管内皮生长因子和结缔组织生长因子在增生型糖尿病视网膜病变中的研究进展[J]. 临床眼科杂志，2015,23(6):573-576.
[5]	冯伟，杨金奎. 2型糖尿病增殖期视网膜病变与血清胆红素水平关系的研究[J]. 首都医科大学学报，2012,33(4):481-484.
[6]	李红霞，崔巍，高伟. 老年2型糖尿病发生增殖性糖尿病视网膜病变的危险因素分析[J]. 内蒙古医学杂志，2013,45(5):517-520.
[7]	王莉莉，刘堃，许迅. 糖尿病性视网膜病变抗血管内皮生长因子治疗进展[J]. 上海交通大学学报(医学版)，2012,32(2):219-225.
[8]	梁辰，施榕，朱静芬，等．上海市浦东新区社区2型糖尿病患者糖尿病性视网膜病变的患病情况及影响因素调查[J]. 中国全科医学，2016,19(4):474-478.
[9]	边菁哲．初诊2型糖尿病患者糖尿病视网膜病变及微血管病变相关性研究[J]. 河北医学，2013,19(12):1866-1868.
[10]	张艳莉，赵岐，黄强. 糖尿病视网膜病变患者血清相关细胞因子水平的研究[J]. 河北医学，2017,23(3):391-394.
[11]	张军，刘森玉. VEGF和bFGF在蒙古族糖尿病视网膜病变中的表达[J]. 国际眼科杂志，2016,16(7):1313-1315.
[12]	孙敏，张少波，宋宗明，等. 增生型糖尿病视网膜病变玻璃体液白介素－18和血管内皮生长因子的定量分析[J]. 中华眼底病杂志，2011,27(3):279-281.
[13]	王伟超，张洁，王虹，等. 泪液肿瘤坏死因子－α水平在糖尿病视网膜病变诊断中的意义[J]. 中国老年学杂志，2017,37(5):1127-1129.
[14]	李昕，郑曰忠. 糖尿病视网膜病变患者血清肿瘤坏死因子－α白细胞介素－2和细胞间粘附分子－1水平检测意义[J]. 中国实用眼科杂志，2013,31(2):111-114.
[15]	李春雷，庞燕，李书丹，等. 血清脂联素、瘦素在糖尿病性视网膜病变早期诊断中的应用[J]．求医问药：下半月刊，2012,10(6):107-107.
[16]	姥勇，屈阳，朱旅云，等. 脂联素与2型糖尿病血管病变的关系[J]. 新乡医学院学报，2011,28(1):89-91.
[17]	张冬艳，马鸿雁，苏军燕，等. 血清结缔组织生长因子、25－羟维生素D、脂联素检测在2型糖尿病视网膜病变诊断及病情评价中的价值[J]. 中国实验诊断学，2017,21(3):505-508.
[18]	陶丽妃，邱一果，雷博. 脂联素与视网膜血管性疾病的相关性[J]. 中华眼底病杂志，2015,31(2):202-205.
[19]	朱巧平，谢安明，郝艳芳. 脂联素对小鼠氧诱导视网膜病变的保护作用[J]. 国际眼科杂志，2015,15(10):1695-1699.
[20]	毛丹娜，蔺涛. 脂联素对1型糖尿病小鼠视网膜节细胞和血管的影响[J]. 世界科技研究与发展，2012,34(3):472-474
[21]	周纯，牛佳媛，蔡洁，等. 糖尿病视网膜病变细胞因子及视网膜血流变化的意义[J]. 国际眼科杂志，2015,15(6):1030-1032.
[22]	石蕊，薛雨顺，王峰. 糖尿病视网膜病变合并白内障患者血清及房水中VEGI和VEGF的含量分析[J]. 陕西医学杂志，2015,44(10):1393-1395.
[23]	郭露，吕红彬. 血管内皮生长因子－2578C/A基因的多态性与糖尿病视网膜病变发生风险的Meta分析[J]. 中华实验眼科杂志，2015,33(1):70-75.
[24]	胡辅华，许玉俊，刘丽林，等. α－硫辛酸对糖尿病大鼠视网膜VEGF表达的影响及机制[J]. 重庆医学，2015,44(25):3463-3465.
[25]	裴瑞，高珩. 复方血栓通胶囊联合羟苯磺酸钙治疗早期糖尿病性视网膜病变的疗效及对hs－CRP、VEGF和IGF－1水平的影响[J]. 现代中西医结合杂志，2015,24(35):3896-3898.
[26]	汪怿，徐洁慧，李韧. 川芎嗪治疗非增殖期糖尿病视网膜病变的临床疗效及其对血清HIF－1、VEGF的影响[J]. 中国临床药理学杂志，2015,31(14):1393-1395.
[27]	王静，朱鸿，施彩虹. 糖尿病大鼠视网膜中内质网应激蛋白、HIF－1α和血管内皮生长因子的表达[J]. 国际眼科杂志，2015,15(5):772-776.
[28]	秦裕辉，李文娟，张熙，等. 双丹明目胶囊对糖尿病视网膜病变大鼠视网膜VEGF和VEGFR蛋白表达的影响[J]. 湖南中医药大学学报，2015,35(6):1-3.
[29]	郭露，吕红彬. 亚洲及欧洲人群血管内皮生长因子基因多态性与糖尿病视网膜病变的相关性meta分析[J]. 中华眼底病杂志，2015,31(2):173-178.
[30]	高玮，王婧，张超，等. 糖尿病视网膜病变患者血清炎症因子和氧化应激指标的检测及意义[J]. 海南医学院学报，2017,23(1):79-81.
[31]	黄淑伟，张龙，路广平，等. 参麦离子导入对糖尿病并发眼底病变患者TGF－β_1及Hcy水平影响研究[J]. 辽宁中医药大学学报，2017,18(6):30-33.
[32]	陈晶，李铁英，关晓海，等. 青蒿琥酯对糖尿病视网膜病变新生血管生成因子ANG、VEGF表达的影响[J]. 中国煤炭工业医学杂志，2016,19(2):248-250.
[33]	钟茜，姚小磊，梁文旺. 增生性糖尿病视网膜病变患者房水中VEGF与IL－6、IL－18相关性研究[J]. 临床眼科杂志，2016,24(3):207-210.
[34]	孙榕，回世洋. 化瘀明目汤治疗不同时期糖尿病视网膜病变疗效对比观察及其对VEGF的影响[J]. 世界中医药，2016,11(1):75-78.
[35]	李沭岩，陆士恒，李祯. 增生型糖尿病视网膜病变抗VEGF治疗后玻璃体液中VEGF及ON测定[J]. 中国实用眼科杂志，2017,35(1):29-31.
[36]	马俊起. 血管内皮生长因子基因多态性与2型糖尿病视网膜病变相关性的Meta分析[J]. 中国中医眼科杂志，2015,25(1):46-49.
[37]	段娜，戴丹，周灵. 血栓通联合眼底激光对糖尿病视网膜病变黄斑水肿患者血清NOS、VEGF和IL－6的影响[J]. 河北医药，2016,38(18):2751-2753.
[38]	饶玉萍，徐玲娟，肖紫云，等. 增生型糖尿病视网膜病变患者血浆和玻璃体中VEGF和低密度脂蛋白受体相关蛋白6的表达及其相关性[J]. 眼科新进展，2016,36(3):278-280
[39]	Giuffr G, Lodato G, Dardanoni G. Prevalence and risk factors of diabetic retinopathy in adult and elderly subjects: The Casteldaccia Eye Study[J]. Graefe's Archive for Clinical and Experimental Ophthalmology, 2004, 242(7):535-540.
[40]	Zhang XZ, Saaddine JB, Chou CF, et al. Prevalence of diabetic retinopathy in the United States, 2005－2008[J]. Jama, 2010, 304(6):649-656.
[41]	Yau JW, Rogers SL, Kawasaki R, et al. Global Prevalence and Major Risk Factors of Diabetic Retinopathy[J]. Diabetes Care, 2012, 35(3):556-564.
[42]	Nicholson BP, Schachat AP. A review of clinical trials of anti－VEGF agents for diabetic retinopathy[J]. Graefes Archive for Clinical & Experimental Ophthalmology, 2010, 248(7):915-930.
[43]	Miller JW, Adamis AP, Aiello LP. Vascular endothelial growth factor in ocular neovascularization and proliferative diabetic retinopathy[J]. Diabetes/metabolism Research & Reviews, 2015, 13(1):37-50.
[44]	Mcarthur K, Feng B, Wu Y, et al. MicroRNA－200b Regulates Vascular Endothelial Growth Factor－Mediated Alterations in Diabetic Retinopathy[J]. Diabetes, 2011, 60(4):1314-1323.
[45]	Kondo H, Shimomura I, Matsukawa Y, et al. Association of adiponectin mutation with type 2 diabetes: a candidate gene for the insulin resistance syndrome[J]. Diabetes, 2002, 51(7):2325-2328.
[46]	王春雁. 糖尿病视网膜病变患者血清VEGF、NO的变化及临床意义[J]. 中国实验诊断学，2015,19(1):94-95.
[47]	孔颖宏，郁秋荣，龚叶，等. 糖尿病视网膜病变与血清TNF－α、IL－2和hs－CRP水平的相关性研究[J]. 北京医学，2016,38(10):1125-1127.
[48]	Solomon SD, Chew E, Duh EJ, et al. Diabetic Retinopathy: A Position Statement by the American Diabetes Association[J]. Diabetes Care, 2017, 40(3):412-418.
[49]	Ding J, Wong TY. Current epidemiology of diabetic retinopathy and diabetic macular edema.[J]. Current Diabetes Reports, 2012, 12(4):346-354.
[50]	Rema M, Srivastava BK, Anitha B, et al. Association of serum lipids with diabetic retinopathy in urban South Indians－The Chennai Urban Rural Epidemiology Study (CURES) Eye Study－2[J]. Diabetic Medicine A Journal of the British Diabetic Association, 2010, 23(9):1029-1036.
[51]	Landers J, Henderson T, Craig JE. Incidence of visual impairment due to cataract, diabetic retinopathy and trachoma in indigenous Australians within central Australia: the Central Australian Ocular Health Study[J]. New Phytologist, 2011, 39(7):604-606.
[52]	Ola MS, Nawaz MI, Siddiquei MM, et al. Recent advances in understanding the biochemical and molecular mechanism of diabetic retinopathy[J]. Biomedicine & Pharmacotherapy, 2012, 26(1):56-64.
[53]	Lip GY, Clementy N, Pierre B, et al. The impact of associated diabetic retinopathy on stroke and severe bleeding risk in diabetic patients with atrial fibrillation: the loire valley atrial fibrillation project[J]. Chest, 2015, 147(4):1103-1110.
[54]	Yamagishi S, Matsui T. Advanced glycation end products (AGEs), oxidative stress and diabetic retinopathy[J]. Current Pharmaceutical Biotechnology, 2011, 12(3):362-368.
[55]	Hammes HP, Feng Y, Pfister F, et al. Diabetic retinopathy: targeting vasoregression[J]. Diabetes, 2011, 60(1):9-16.
[56]	Listed N. A protocol for screening for diabetic retinopathy in Europe. Retinopathy Working Party[J]. Diabetic Medicine A Journal of the British Diabetic Association, 2010, 8(3):263-267.
[57]	Marshall G, Jones RH. Multi－state models and diabetic retinopathy[J]. Statistics in Medicine, 2010, 14(18):1975-1983.

组别	性别(男/女)	平均年龄(岁)	平均病程(年)	空腹血糖(mmol/L)	空腹胰岛素(miu/L)	身体质量指数(kg/m²)	收缩压(mmHg)
对照组	28/22	50.9±10.3	0	5.16±0.58	10.20±3.02	24.51±1.03	125.1±6.9
NDR组	26/24	51.2± 9.8	4.3±1.5	6.33±1.84	12.18±3.55	24.68±1.16	127.0±7.1
NPDR组	29/21	56.1±11.0	11.1±3.3	6.75±2.01	14.14±3.61	24.54±1.21	130.5±7.0
PDR组	26/24	57.6±10.6	13.6±3.6	7.06±1.82	16.10±4.02	24.41±1.35	132.6±7.3
统计量	0.544^*	5.329	96.434	12.510	25.305	0.583	0.440
P值	>0.05	<0.05	<0.05	<0.05	<0.05	>0.05	>0.05
组别	舒张压(mmHg)	TG(mmol/L)	总胆固醇(mmol/L)	HDL－C(mmol/L)	LDL－C(mmol/L)	高血压病史(有/无)	糖尿病家族病史(有/无)	肌氨酸酐(μmol/L)
对照组	80.3±4.4	1.41±0.50	5.10±1.41	1.53±0.51	3.11±1.01	0/50	6/44	53.3±9.3
NDR组	79.8±4.6	2.10±0.52	5.41±1.55	1.42±0.48	3.15±1.21	14/36	9/41	58.1±8.9
NPDR组	80.5±4.1	1.88±0.49	5.45±1.58	1.23±0.46	3.19±1.33	16/34	5/45	64.1±7.7
PDR组	80.8±4.9	1.90±0.53	5.43±1.57	1.25±0.51	3.20±1.38	16/34	7/43	72.5±8.1
统计量	0.434	16.419	0.587	4.259	0.055	20.215^*	1.499^*	47.158
P值	>0.05	<0.05	>0.05	<0.05	>0.05	<0.05	>0.05	<0.05

组别	性别(男/女)	平均年龄(岁)	平均病程(年)	空腹血糖(mmol/L)	空腹胰岛素(miu/L)	身体质量指数(kg/m²)	收缩压(mmHg)
对照组	28/22	50.9±10.3	0	5.16±0.58	10.20±3.02	24.51±1.03	125.1±6.9
NDR组	26/24	51.2± 9.8	4.3±1.5	6.33±1.84	12.18±3.55	24.68±1.16	127.0±7.1
NPDR组	29/21	56.1±11.0	11.1±3.3	6.75±2.01	14.14±3.61	24.54±1.21	130.5±7.0
PDR组	26/24	57.6±10.6	13.6±3.6	7.06±1.82	16.10±4.02	24.41±1.35	132.6±7.3
统计量	0.544^*	5.329	96.434	12.510	25.305	0.583	0.440
P值	>0.05	<0.05	<0.05	<0.05	<0.05	>0.05	>0.05
组别	舒张压(mmHg)	TG(mmol/L)	总胆固醇(mmol/L)	HDL－C(mmol/L)	LDL－C(mmol/L)	高血压病史(有/无)	糖尿病家族病史(有/无)	肌氨酸酐(μmol/L)
对照组	80.3±4.4	1.41±0.50	5.10±1.41	1.53±0.51	3.11±1.01	0/50	6/44	53.3±9.3
NDR组	79.8±4.6	2.10±0.52	5.41±1.55	1.42±0.48	3.15±1.21	14/36	9/41	58.1±8.9
NPDR组	80.5±4.1	1.88±0.49	5.45±1.58	1.23±0.46	3.19±1.33	16/34	5/45	64.1±7.7
PDR组	80.8±4.9	1.90±0.53	5.43±1.57	1.25±0.51	3.20±1.38	16/34	7/43	72.5±8.1
统计量	0.434	16.419	0.587	4.259	0.055	20.215^*	1.499^*	47.158
P值	>0.05	<0.05	>0.05	<0.05	>0.05	<0.05	>0.05	<0.05

组别	例数	HMW－ADP(μg/ml)	TNF－α(μg/L)	VEGF(μg/L)
对照组	50	2.51±0.26	6.8±1.6	52.1±11.3
NDR组	50	1.65±0.20^△	8.0±1.8^△	120.6±15.5^△
NPDR组	50	1.44±0.18^△▲	11.9±1.6^△▲	160.6±21.2^△▲
PDR组	50	1.45±0.13^△▲	16.6±2.9^△▲	225.3±28.7^△▲
F值	?	362.480	239.200	641.970
P值	?	<0.05	<0.05	<0.05

组别	例数	HMW－ADP(μg/ml)	TNF－α(μg/L)	VEGF(μg/L)
对照组	50	2.51±0.26	6.8±1.6	52.1±11.3
NDR组	50	1.65±0.20^△	8.0±1.8^△	120.6±15.5^△
NPDR组	50	1.44±0.18^△▲	11.9±1.6^△▲	160.6±21.2^△▲
PDR组	50	1.45±0.13^△▲	16.6±2.9^△▲	225.3±28.7^△▲
F值	?	362.480	239.200	641.970
P值	?	<0.05	<0.05	<0.05

项目	回归系数	标准误	Waldχ²	P值	OR值	95%可信区间
年龄	0.038	0.012	7.621	<0.05	1.056	1.013～1.072
病程	0.582	0.081	18.331	<0.05	1.913	1.346～2.335
HDL－C	－1.318	0.451	6.694	<0.05	0.335	0.128～0.649
TNF－α	0.201	0.076	5.532	<0.05	1.361	1.058～1.943
HMW－ADP	－0.805	0.212	10.671	<0.05	0.494	0.106～0.893
VEGF	0.381	0.064	5.618	<0.05	1.895	1.173～2.205

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项目	回归系数	标准误	Waldχ²	P值	OR值	95%可信区间
年龄	0.041	0.018	6.962	<0.05	1.378	1.114～2.210
病程	0.473	0.092	11.542	<0.05	2.011	1.642～3.138
HDL－C	－1.152	0.431	5.674	<0.05	0.377	0.162～0.761
TNF－α	0.334	0.081	5.615	<0.05	1.189	1.072～1.957
HMW－ADP	－0.620	0.138	7.671	<0.05	0.388	0.059～0.928
VEGF	0.359	0.054	5.331	<0.05	1.621	1.104～2.031

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