Advance on ocular bacterial species influence on ocular health status in infants and children

doi:10.3877/cma.j.issn.2095-2007.2023.02.010

Abstract

Abstract:

Various types of bacteria exist in the human eye and maintain a dynamic balance under normal conditions, which is important to regulate host metabolism, promote immune system development, and defend against pathogen invasion. It has been demonstrated that the bacteria species imbalance was associated with various ophthalmic diseases. Infants and children have a higher risk of infection and rate of progression of infectious eye disease than adults due to underdeveloped ocular tissues, lower anti-infective capacity. Therefore, understanding the relationship between the occurrence and development of various ocular diseases and ocular bacteria in infants and children is important for the diagnosis and treatment of the disease. In this paper, the changes of the bacteria of the eye with the ocular health and disease conditions in infants and children were summarized and compared, in order to provide references for clinical diagnosis and treatment and related research.

Key words: Ocular bacteria species, High throughput sequencing, Infants, Children, Eye diseases

Haoyue Xu, Kui Dong, Xuan Ji, Zhiming Kang, Junhong Li. Advance on ocular bacterial species influence on ocular health status in infants and children[J]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2023, 13(02): 114-118.

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References 56

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阶段	年龄	第一作者	年份(年)	地区	检测方法	病例数(例)	主要细菌
婴幼儿	0~48 h	Lee等^[12]	1989	韩国	培养	112	表皮葡萄球菌、大肠埃希菌及金黄色葡萄球菌
	<1 h	Isenberg等^[10]	1988	美国	培养	56例阴道分娩	双歧杆菌、乳酸杆菌及大肠杆菌
						50剖宫产	双歧杆菌、金黄色葡萄球菌及肠球菌
	<12 h	Eder等^[11]	2005	德国	培养	126例阴道分娩	凝固酶阴性葡萄球菌、丙酸杆菌及棒状杆菌
						64例剖宫产	凝固酶阴性葡萄球菌、丙酸杆菌、金黄色葡萄球菌及乳酸菌
	24 h	Kara等^[13]	2018	美国	培养	95	凝固酶阴性葡萄球菌和金黄色葡萄球菌
儿童	1~4月	华宁等^[14]	2010	中国	培养	109	类白喉棒状杆菌和表皮葡萄球菌
	<14岁	Kara等^[13]	2018	美国	培养	50	葡萄球菌和绿色链球菌
					基因测序	50	变形菌门、厚壁菌门、拟杆菌门及放线菌门
	<18岁	Cavuoto等^[3]	2019	美国	基因测序	30	变形菌门、厚壁菌门、拟杆菌门及放线菌门
	<10岁	Zhou等^[17]	2014	冈比亚	基因测序	21	放线菌门、变形菌门及厚壁菌门
	<18岁	Leonardi等^[18]	2021	意大利	基因测序	20	变形菌门、厚壁菌门、放线菌门及拟杆菌门
	<5岁	Doan等^[19]	2020	尼日尔	基因测序	15	嗜血杆菌、莫拉氏菌、乳酸杆菌及链球菌

阶段	年龄	第一作者	年份(年)	地区	检测方法	病例数(例)	主要细菌
婴幼儿	0~48 h	Lee等^[12]	1989	韩国	培养	112	表皮葡萄球菌、大肠埃希菌及金黄色葡萄球菌
	<1 h	Isenberg等^[10]	1988	美国	培养	56例阴道分娩	双歧杆菌、乳酸杆菌及大肠杆菌
						50剖宫产	双歧杆菌、金黄色葡萄球菌及肠球菌
	<12 h	Eder等^[11]	2005	德国	培养	126例阴道分娩	凝固酶阴性葡萄球菌、丙酸杆菌及棒状杆菌
						64例剖宫产	凝固酶阴性葡萄球菌、丙酸杆菌、金黄色葡萄球菌及乳酸菌
	24 h	Kara等^[13]	2018	美国	培养	95	凝固酶阴性葡萄球菌和金黄色葡萄球菌
儿童	1~4月	华宁等^[14]	2010	中国	培养	109	类白喉棒状杆菌和表皮葡萄球菌
	<14岁	Kara等^[13]	2018	美国	培养	50	葡萄球菌和绿色链球菌
					基因测序	50	变形菌门、厚壁菌门、拟杆菌门及放线菌门
	<18岁	Cavuoto等^[3]	2019	美国	基因测序	30	变形菌门、厚壁菌门、拟杆菌门及放线菌门
	<10岁	Zhou等^[17]	2014	冈比亚	基因测序	21	放线菌门、变形菌门及厚壁菌门
	<18岁	Leonardi等^[18]	2021	意大利	基因测序	20	变形菌门、厚壁菌门、放线菌门及拟杆菌门
	<5岁	Doan等^[19]	2020	尼日尔	基因测序	15	嗜血杆菌、莫拉氏菌、乳酸杆菌及链球菌

第一作者(发表年份)	地区	例数	金黄色葡萄球菌	葡萄球菌^*	链球菌	假单胞菌	病原体种类
Al－Otaibi等^[23](2012)	沙特阿拉伯	68	6	7	8	6	7
Yu等^[32](2016)	巴西	859	72	82	67	49	20
Green等^[33](2019)	澳大利亚	134	17	36	17	24	9
Singh等^[34](2006)	印度	97	7	16	6	18	18
Song等^[35](2012)	中国武汉	76	1	14		6	12
Young等^[36](2013)	中国香港	18	1	4	0	11	4
Rossetto等^[37](2017)	美国	108	2	4		24	16
Brook^[38](2001)	美国	119	12		17	1	17

第一作者(发表年份)	地区	例数	金黄色葡萄球菌	葡萄球菌^*	链球菌	假单胞菌	病原体种类
Al－Otaibi等^[23](2012)	沙特阿拉伯	68	6	7	8	6	7
Yu等^[32](2016)	巴西	859	72	82	67	49	20
Green等^[33](2019)	澳大利亚	134	17	36	17	24	9
Singh等^[34](2006)	印度	97	7	16	6	18	18
Song等^[35](2012)	中国武汉	76	1	14		6	12
Young等^[36](2013)	中国香港	18	1	4	0	11	4
Rossetto等^[37](2017)	美国	108	2	4		24	16
Brook^[38](2001)	美国	119	12		17	1	17

类型	第一作者	年份	地区	培养阳性数	主要致病菌及比例
外伤眼内炎	Al－Rashaed等^[40]	2006	沙特阿拉伯	35	链球菌种53.7%
	Cakir等^[41]	2010	土耳其	3	肺炎链球菌66.7%和凝固酶阴性葡萄球菌33.3%
	Wu等^[42]	2016	中国	10	表皮葡萄球菌33.3%和镰刀菌8.3%
	Rishi等^[43]	2016	印度	55	粪肠球菌14.5%和沙雷氏克雷伯菌10.9%
	Yang等^[24]	2019	中国	26	凝固酶阴性葡萄球菌14.8%和枯草芽孢杆菌14.8%
术后眼内炎	Al－Rashaed等^[40]	2006	沙特阿拉伯	14	表皮葡萄球菌26.6%和副流感嗜血杆菌20.0%
	Parvizi等^[39]	2020	美国	8	链球菌28.6%、凝固酶阴性葡萄球菌28.6%、副流感嗜血杆菌14.3%及嗜麦芽寡养单胞菌14.3%
	Agarkar等^[44]	2016	印度	4	醋酸钙不动杆菌50%和耐甲氧西林金黄色葡萄球菌25%
内源性眼内炎	Murugan等^[45]	2016	印度	5	葡萄球菌20.0%、铜绿假单胞菌20.0%、脑膜炎奈瑟菌20.0%、黄曲霉菌20.0%及念珠菌20.0%
	Maitray等^[46]	2019	印度	21	表皮葡萄球菌14.3%、化脓性链球菌14.3%、假单胞菌9.5%及白色念珠菌9.5%
混合性眼内炎	Zhang等^[47]	2016	中国	147	表皮葡萄球菌20.5%
	Thordsen等^[48]	2008	美国	12	肺炎链球菌25%和流感嗜血杆菌25%

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