Research progress of the effect of estrogen deficiency on the lacrimal gland

doi:10.3877/cma.j.issn.2095-2007.2021.04.011

Abstract

Abstract:

Estrogen is essential for maintaining the structure and function of lacrimal gland. Estrogen deficiency can adversely affect the lacrimal glands, which can cause some lacrimal autoimmune diseases. The main pathological characteristics of lacrimal autoimmune diseases are acinar cell apoptosis and inflammatory cell infiltration. Estrogen plays a great role in anti-apoptosis, which can protect the lacrimal gland cells from apoptotic programmed death. During perimenopausal period, estrogen deficiency will increase the number of apoptotic cells in female. The product produced after apoptosis process, as the autologous antigen, can activate the plasmacytoid dendritic cells (PDC) that promote inflammatory cell to infiltrate and secrete cytokines, which can cause the autoimmune diseases.

Key words: Estrogen, Lacrimal gland diseases, Cell apoptosis, Inflammatory cell infiltration, Plasmacytoid dendritic cell

Ziyan Zhao, Yi Ding, Jianmin Ma. Research progress of the effect of estrogen deficiency on the lacrimal gland[J]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2021, 11(04): 252-256.

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分类		病种
炎症性疾病
	感染性疾病	泪腺炎(细菌性、病毒性及结核性等)
	自身免疫性疾病	泪腺良性淋巴上皮病变、原发性干燥综合征、炎性假瘤及肉芽肿性血管炎等
肿瘤性疾病
	良性肿瘤	多形性腺瘤、泪腺囊肿及肌上皮瘤等
	恶性肿瘤	腺样囊性癌、腺癌、囊腺癌、多形性腺瘤癌、黏液表皮样癌及转移癌等

分类		病种
炎症性疾病
	感染性疾病	泪腺炎(细菌性、病毒性及结核性等)
	自身免疫性疾病	泪腺良性淋巴上皮病变、原发性干燥综合征、炎性假瘤及肉芽肿性血管炎等
肿瘤性疾病
	良性肿瘤	多形性腺瘤、泪腺囊肿及肌上皮瘤等
	恶性肿瘤	腺样囊性癌、腺癌、囊腺癌、多形性腺瘤癌、黏液表皮样癌及转移癌等

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