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中华眼科医学杂志(电子版) ›› 2024, Vol. 14 ›› Issue (04) : 247 -251. doi: 10.3877/cma.j.issn.2095-2007.2024.04.010

综述

晚期糖化终末产物与糖尿病视网膜病变相关性的研究进展
罗桂彬1, 沈强1, 张蓝月1, 刘涵1,()   
  1. 1.402260 重庆大学附属江津医院眼科
  • 收稿日期:2024-07-24 出版日期:2024-08-28
  • 通信作者: 刘涵
  • 基金资助:
    重庆市自然科学基金面上项目(CSTB2023NSCQMSX1061,CSTB2023NSCQ-MSX0639)重庆市江津区科学技术局项目(Y2023016)

The advances on the correlation between advanced glycation end-products and diabetic retinopathy

Guibin Luo1, Qiang Shen1, Lanyue Zhang1, Han Liu1,()   

  1. 1.Department of Ophthalmology,Chongqing University Jiangjin Hospital,Chongqing 402260,China
  • Received:2024-07-24 Published:2024-08-28
  • Corresponding author: Han Liu
引用本文:

罗桂彬, 沈强, 张蓝月, 刘涵. 晚期糖化终末产物与糖尿病视网膜病变相关性的研究进展[J/OL]. 中华眼科医学杂志(电子版), 2024, 14(04): 247-251.

Guibin Luo, Qiang Shen, Lanyue Zhang, Han Liu. The advances on the correlation between advanced glycation end-products and diabetic retinopathy[J/OL]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2024, 14(04): 247-251.

糖尿病会引起糖尿病视网膜病变(DR),是成人失明和低视力的重要原因。晚期糖化终末产物(AGE)是由葡萄糖或其他糖类对蛋白质、脂类及核酸等大分子进行翻译后非酶修饰而产生的分子,AGE与晚期糖基化终产物受体(RAGE)结合后会产生一系列病理机制,是参与DR发生与进展的重要因素。AGE抑制剂、AGE阻滞剂及RAGE抑制剂是未来DR潜在的治疗靶点。本文中笔者就AGE与DR的相关性进行综述,旨在为DR的诊疗提供新思路。

Diabetes causes diabetic retinopathy(DR),which is an important cause of blindness and low vision in adults.Advanced glycation end products(AGE)are molecules produced by non enzymatic modification of large molecules such as proteins,lipids,and nucleic acids through translation by glucose or other sugars.Binding of AGE to the receptor for advanced glycosylation end products(RAGE)can produce a series of pathological mechanisms,which are important factors involved in the occurrence and progression of DR.AGE inhibitors,AGE blockers,and RAGE inhibitors are potential therapeutic targets for DR in the future.The correlation between AGE and DR was reviewed in this paper,aiming to provide insights for the diagnosis and treatment of DR.

图1 体内晚期糖化终末产物的产生过程示意图 在高糖环境上,葡萄糖与蛋白质、脂质或核酸的游离氨基发生美拉德反应,生成希夫碱,后经葡糖胺重排形成更稳定的早期糖基化产物,再又经一系列脱水和氧化及缩合等反应,生成不可逆的晚期糖化终末产物
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