Abstract:

Objective

To compare the differences and consistency in total ocular and internal higherorder aberrations（HOAs）measured by OPD-scanⅢand iTrace in patients after ICL surgery.

Methods

A total of 96 patients with myopia who underwent ICL surgery at the Department of Ophthalmology and Optometry of Beijing Tongren Hospital affiliated with Capital Medical University from June 2023 to December 2023 were collected.Among them，there were46 male patients（46 eyes）and 50 female patients（50 eyes）with an average age of（28.3±6.2）years（ranging from 20 to 49 years）.OPD-scanⅢand iTrace were used to measure the root mean square values of HOAs，ocular aberrations，ocular coma，ocular trefoil，intraocular HOAs，intraocular spherical aberrations，and intraocular trefoil in the whole eye when the pupil size was 4 mm in a dark environment.After testing，the patient's age，equivalent refractive power，high-order aberration of the whole eye，total ocular aberration，total ocular aberration，total ocular trefoil aberration，intraocular high-order aberration，intraocular spherical aberration，and intraocular trefoil aberration were found to be normally distributed，as indicated by±s.The differences in measurement indicators between the two devices were analyzed using a paired sample t test.The consistency of the measurement indicators between the two devices was analyzed using the Bland-Altman test.

Results

Bland-Altman analysis showed that the mean differences（95% limits of agreement）in RMSvalues between OPD-scanⅢand iTrace for total ocular HOAs，total ocular spherical aberration，total ocular coma，total ocular trefoil，internal HOAs，internal spherical aberration，internal coma，and internal trefoil were 0.03（-0.13～0.19）μm，0.01（-0.05～0.07）μm，-0.01（-0.11～0.08）μm，0.06（-0.08～0.21）μm，0.03（-0.15～0.21）μm，0.02（-0.05～0.10）μm，-0.00（-0.15～0.15）μm，and 0.04（-0.11～0.20）μm，respectively.The percentages of points outside the 95% limits of agreement were 5.2% （5/96），3.1% （3/96），3.1% （3/96），7.3% （7/96），3.1% （3/96），4.2% （4/96），6.3% （6/96），and 3.1% （3/96），respectively.The root mean square values of total ocular HOAs，total ocular spherical aberration，total ocular coma，total ocular trefoil，internal HOAs，internal spherical aberration，and internal trefoil measured by OPD-scanⅢand iTrace were（0.231±0.080）μm and（0.199±0.078）μm，（0.042±0.033）μm and（0.034±0.024）μm，（0.067±0.040）μm and（0.080±0.046）μm，（0.191±0.086）μm and（0.131±0.071）μm，（0.202±0.069）μm and（0.171±0.073）μm，（0.074±0.037）μm and（0.049±0.036）μm，and（0.131±0.071）μm and（0.086±0.053）μm，respectively.The differences were statistically significant（t＝3.603，2.400，-2.621，7.603，3.207，6.040，6.216；P＜0.05）.The root mean square values of internal coma measured by OPD-scanⅢand iTrace were（0.081±0.057）μm and（0.083±0.051）μm，respectively，with no statistically significant difference（t＝-0.263，P＞0.05）.

Conclusions

Although the consistency between OPD-scanⅢand iTrace in measuring overall HOAs，overall spherical aberrations，overall coma，overall trefoil aberrations，intraocular HOAs，intraocular spherical aberrations，intraocular coma，and intraocular trefoil aberrations is relatively good，paired test results indicate that，except for intraocular coma，significant differences exist in the measurements of overall HOAs，overall spherical aberrations，overall coma，overall trefoil aberrations，intraocular HOAs，intraocular spherical aberrations，and intraocular trefoil aberrations between the two devices.Given that ordinary patients may not notice minor differences in visual perception，while patients with high-precision visual needs and better night vision needs may perceive these differences more distinctly，it is recommended that，for patients with high-precision visual needs and better night vision needs，except for intraocular coma，the measurement data of overall HOAs，overall spherical aberrations，overall coma，overall trefoil aberrations，intraocular HOAs，intraocular spherical aberrations，intraocular coma，and intraocular trefoil aberrations from OPD ｜scanⅢ and iTrace should not be interchangeably used.

Key words: OPD-scanⅢ, iTrace, ICL, Higher-order aberrations, Internal ocular aberrations