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Chinese Journal of Ophthalmologic Medicine(Electronic Edition) ›› 2024, Vol. 14 ›› Issue (05): 316-320. doi: 10.3877/cma.j.issn.2095-2007.2024.05.011

• Review • Previous Articles    

Research progress in the correlation between transforming growth factor beta and diabetic retinopathy

Han Liu1, Lanyue Zhang1, Qiang Shen1, Yanhong Fang1, Shuang Zhou2,()   

  1. 1.Department of Ophthalmology,Chongqing University Jiangjin Hospital,Chongqing 402260,China
    2.Department of Geriatrics,Jiangjin District Hospital of Traditional Chinese Medicine,Chongqing 402260,China
  • Received:2024-08-27 Online:2024-10-28 Published:2025-02-27
  • Contact: Shuang Zhou

Abstract:

Diabetes causes diabetic retinopathy(DR),which is an important cause of blindness in adults.Transforming growth factorβ(TGF-β)has both pro-angiogenic and anti-angiogenic effects in the eye.It has demonstrated that the steady-state imbalance of TGF-β is involved in the occurrence and progression of DR.High-glucose environment leads to excessive production of TGF-β,which is a pathogenic factor causing DR.However,physiological levels of TGF-βmay also be a protective factor for the retina.In the targeted therapy of DR,anti-TGF-βor maintenance of TGF-βhomeostasis from genetic,molecular,in vitro models and animal experiments have emerged.Traditional Chinese medicine and natural extracts also contain anti TGF-β substances,which can help improve the condition of DR patients.The correlation between TGF-βand DR and the potential anti TGF-βtherapy for DR,with the aim of serving clinical DR treatment and research were reviewed in this paper.

Key words: Diabetes mellitus, Diabetic retinopathy, Transforming growth factor beta, Traditional Chinese medicine, Correlation

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