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Chinese Journal of Ophthalmologic Medicine(Electronic Edition) ›› 2024, Vol. 14 ›› Issue (05): 310-315. doi: 10.3877/cma.j.issn.2095-2007.2024.05.010

• Review • Previous Articles    

New advances in research on caspase-1-mediated pyroptosis in the field of ophthalmology

Zhenzhen Ji1, Zhijian Li1,()   

  1. 1.Department of Ophthalmology,First Affiliated Hospital of Harbin Medical University,Harbin 150000,China
  • Received:2024-08-08 Online:2024-10-28 Published:2025-02-27
  • Contact: Zhijian Li

Abstract:

Pyroptosis is a new type of programmed cell death,which is characterized by cell death mediated by inflammatory caspase-1.In recent years,the role of pyroptosis in the pathogenesis of a variety of diseases has been widely concerned,and its role in eye diseases has gradually emerged.Caspase-1 is activated by assembling nucleotide binding oligomerization domain like receptor protein 3 inflammasome,which cleaves gsdmd protein and induces cell membrane to form holes,leading to cell swelling and rupture and the release of pro-inflammatory cytokines interleukin(IL)-1βand IL-18,leading to cell death,causing local and systemic inflammatory reactions.It has been demonstrated that caspase-1-mediated pyroptosis has been closely related to the occurrence and progress of a variety of eye diseases,such as keratitis,cataract,glaucoma and age-related macular degeneration.The latest research progress of caspase-1-mediated pyroptosis in the field of ophthalmology was reviewed in this paper.

Key words: Pyroptosis, Caspase-1, Eye Diseases, GSDMD, NLRP3

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