[1] |
Asbell P,Dualan I,Mindel J,et al.Age-related cataract[J].Lancet,2005,365(9459):599-609.
|
[2] |
Liu Y C,Wilkins M,Kim T,et al.Cataracts[J].Lancet,2017,390(10094):600-612.
|
[3] |
Causes of blindness and vision impairment in 2020 and trends over 30 years,and prevalence of avoidable blindness in relation to VISION 2020:the Right to Sight:an analysis for the Global Burden of Disease Study[J].Lancet Glob Health,2021,9(2):e144-e160.
|
[4] |
Foretz M, Guigas B, Viollet B. Metformin: update on mechanisms of action and repurposing potential[J].Nat Rev Endocrinol,2023,19(8):460-476.
|
[5] |
Cabreior F,Au C,Leung K,et al.Metformin retards aging in C.elegans by altering microbial folate and methionine metabolism[J].Cell,2013,153(1):228-239.
|
[6] |
Yu H,Zhong X,Gao P,et al.The potential effect of metformin on cancer: an umbrella review [J]. Front Endocrinol(Lausanne),2019,10:617.
|
[7] |
Amin S,Khanna S,Parvar S,et al.Metformin and retinal diseases in preclinical and clinical studies:Insights and review of literature[J].Exp Biol Med(Maywood),2022,247(4):317-329.
|
[8] |
Hurley D,Irnaten M,O'brien C.Metformin and glaucoma-review of anti-fibrotic processes and bioenergetics[J].Cells,2021,10(8):2131.
|
[9] |
Delamere N,Tamiya S.Lens ion transport:from basic concepts to regulation of Na,K-ATPase activity[J].Exp Eye Res,2009,88(2):140-143.
|
[10] |
Andley U.The lens epithelium:focus on the expression and function of the alpha-crystallin chaperones[J].Int J Biochem Cell Biol,2008,40(3):317-323.
|
[11] |
Augusteyn R.On the growth and internal structure of the human lens[J].Exp Eye Res,2010,90(6):643-654.
|
[12] |
Mcnulty R,Wang H,Mathias R,et al.Regulation of tissue oxygen levels in the mammalian lens[J].J Physiol,2004,559(Pt3):883-898.
|
[13] |
Lu A,Duan P,Xie J,et al.Recent progress and research trend of anti-cataract pharmacology therapy:A bibliometric analysis and literature review[J].Eur J Pharmacol,2022,934:175299.
|
[14] |
Wishart T,Flokis M,Shu D,et al.Hallmarks of lens aging and cataractogenesis[J].Exp Eye Res,2021,210:108709.
|
[15] |
Murphy M.How mitochondria produce reactive oxygen species[J].Biochem J,2009,417(1):1-13.
|
[16] |
Wang C,Wu S,Wu Y,et al.Oxidative stress response elicited by mitochondrial dysfunction:implication in the pathophysiology of aging[J].Exp Biol Med(Maywood),2013,238(5):450-460.
|
[17] |
Yang H,Cui Y,Tang Y,et al.Cytoprotective role of humanin in lens epithelial cell oxidative stress-induced injury[J].Mol Med Rep,2020,22(2):1467-1479.
|
[18] |
Michael R,Bron A.The ageing lens and cataract:a model of normal and pathological ageing[J].Philos Trans R Soc Lond B Biol Sci,2011,366(1568):1278-1292.
|
[19] |
Anbaraki A,Khoshaman K,Ghasemi Y,et al.Preventive role of lens antioxidant defense mechanism against riboflavin-mediated sunlight damaging of lens crystallins[J].Int J Biol Macromol,2016,91:895-904.
|
[20] |
Picklo M,Long E,Vomhof-dekrey E.Glutathionyl systems and metabolic dysfunction in obesity[J].Nutr Rev,2015,73(12):858-868.
|
[21] |
Shiels A,Hejtmancik J.Mutations and mechanisms in congenital and age-related cataracts[J].Exp Eye Res,2017,156:95-102.
|
[22] |
Kulkarni A,Gubbi S,Barzilai N.Benefits of metformin in attenuating the hallmarks of aging[J].Cell Metab,2020,32(1):15-30.
|
[23] |
Lv Z,Guo Y.Metformin and its benefits for various diseases[J].Front Endocrinol(Lausanne),2020,11:191.
|
[24] |
Dutta S,Shah R,Singhal S,et al.Metformin:A review of potential mechanism and therapeutic utility beyond diabetes[J].Drug Des Devel Ther,2023,17:1907-1932.
|
[25] |
Vergroesen J,Thee E,Ahmadizar F,et al.Association of diabetes medication with open-angle glaucoma, age-related macular degeneration,and cataract in the rotterdam study[J].JAMA Ophthalmol,2022,140(7):674-681.
|
[26] |
Martin-montalvo A,Mercken E,Mitchell S,et al.Metformin improves healthspan and lifespan in mice[J].Nat Commun,2013,4:2192.
|
[27] |
Onken B,Driscoll M.Metformin induces a dietary restriction-like state and the oxidative stress response to extend C.elegans Healthspan via AMPK,LKB1,and SKN-1[J].PLoS One,2010,5(1):e8758.
|
[28] |
Kulkarni A,Aleksic S,Berger D,et al.Geroscience-guided repurposing of FDA-approved drugs to target aging:A proposed process and prioritization [J]. Aging Cell, 2022, 21(4):e13596.
|
[29] |
薛朝军,刘克辛.二甲双胍抗肿瘤机制的研究进展[J].药学学报,2015,50(10):1210-1216.
|
[30] |
Saavedra D,Aňé-kouri A,Barzilai N,et al.Aging and chronic inflammation:highlights from a multidisciplinary workshop[J].Immun Ageing,2023,20(1):25.
|
[31] |
Chen S,Gan D,Lin S,et al.Metformin in aging and agingrelated diseases:clinical applications and relevant mechanisms[J].Theranostics,2022,12(6):2722-2740.
|
[32] |
Moreno-navarrete J,Ortega F,Rodriguze-hermosa J,et al.OCT1 Expression in adipocytes could contribute to increased metformin action in obese subjects[J].Diabetes,2011,60(1):168-176.
|
[33] |
Sarfstein R,Friedman Y,Attias-geva Z,et al.Metformin downregulates the insulin/IGF-I signaling pathway and inhibits different uterine serous carcinoma(USC)cells proliferation and migration in p53-dependent or-independent manners[J].PLoS One,2013,8(4):e61537.
|
[34] |
Cameron A,Morrison V,Levin D,et al.Anti-inflammatory effects of metformin irrespective of diabetes status[J].Circ Res,2016,119(5):652-665.
|
[35] |
Yang F,Qin Y,Wang Y,et al.Metformin Inhibits the NLRP3 inflammasome via AMPK/mTOR-dependent effects in diabetic cardiomyopathy[J].Int JBiol Sci,2019,15(5):1010-1019.
|
[36] |
Mahammed I,Hollenberg M,Ding H,et al.A critical review of the evidence that metformin is a putative anti-aging drug that enhances healthspan and extends lifespan[J].Front Endocrinol(Lausanne),2021,12:718942.
|
[37] |
Fang J,Yang J,Wu X,et al.Metformin alleviates human cellular aging by upregulating the endoplasmic reticulum glutathione peroxidase 7 [J]. Aging Cell, 2018, 17(4):e12765.
|
[38] |
Hartwig J,Loebel M,Steiner S,et al.Metformin attenuates ROS via FOXO3 activation in immune cells[J].Front Immunol,2021,12:581799.
|
[39] |
Sabzali M,Eidi A,Khaksari M,et al.Anti-inflammatory,antioxidant,and antiapoptotic action of metformin attenuates ethanol neurotoxicity in the animal model of fetal alcohol spectrum disorders[J].Neurotox Res,2022,40(2):605-613.
|
[40] |
Urpilainen E,Kangaskokko J,Puistola U,et al.Metformin diminishes the unfavourable impact of Nrf2 in breast cancer patients with type 2 diabetes[J].Tumour Biol,2019,41(1):1010428318815413.
|
[41] |
Bauer P,Duca F,Waise T,et al.Metformin alters upper small intestinal microbiota that impact a glucose-SGLT1-sensing glucoregulatory pathway[J].Cell Metab,2018,27(1):101-117.
|
[42] |
Lee H,Lee Y,Kim J,et al.Modulation of the gut microbiota by metformin improves metabolic profiles in aged obese mice[J].Gut Microbes,2018,9(2):155-165.
|
[43] |
Kandarakis S,Piperi C,Topouzis F,et al.Emerging role of advanced glycation-end products(AGEs)in the pathobiology of eye diseases[J].Prog Retin Eye Res,2014,42:85-102.
|
[44] |
Zhou Z,Tang Y,Jin X,et al.Metformin inhibits advanced glycation end products-induced inflammatory response in murine macrophages partly through AMPK activation and RAGE/NFκB pathway suppression [J]. J Diabetes Res, 2016,2016:4847812.
|
[45] |
Hardie D.AMPK:a target for drugs and natural products with effects on both diabetes and cancer[J].Diabetes,2013,62(7):2164-2172.
|
[46] |
Cheang W,Tian X, Wong W, et al. Metformin protects endothelial function in diet-induced obese mice by inhibition of endoplasmic reticulum stress through 5'adenosine monophosphateactivated protein kinase-peroxisome proliferator-activated receptor δpathway[J].Arterioscler Thromb Vasc Biol,2014,34(4):830-836.
|
[47] |
Zhao M,Li X,Chen Z,et al.Neuro-protective role of metformin in patients with acute stroke and type 2 diabetes mellitus via AMPK/mammalian target of rapamycin (mTOR) signaling pathway and oxidative stress[J].Med Sci Monit,2019,25:2186-2194.
|
[48] |
Ren H,Shao Y,Wu C,et al.Metformin alleviates oxidative stress and enhances autophagy in diabetic kidney disease via AMPK/SIRT1-FoxO1 pathway[J].Mol Cell Endocrinol,2020,500:110628.
|
[49] |
Chin S,Ha I,Rhee S,et al.Clinical characteristics and prevalence of comorbidities according to metformin use in Korean patients with type 2 diabetes[J].Int J Endocrinol,2020,PMID:32774367.
|
[50] |
燕朱轩,吕洋.二甲双胍在年龄相关性眼病中应用的研究进展[J].国际眼科杂志,2023,23(5):768-773.
|
[51] |
王旭,齐艳华.二甲双胍在眼科的应用前景[J].国际眼科杂志,2017,17(4):673-676.
|
[52] |
Chen M,Zhang C,Zhou N,et al.Metformin alleviates oxidative stress-induced senescence of human lens epithelial cells via AMPK activation and autophagic flux restoration[J].J Cell Mol Med,2021,25(17):8376-8389.
|
[53] |
Chhunchha B,Kubo E,Singh D.Obligatory role of ampk activation and antioxidant defense pathway in the regulatory effects of metformin on cellular protection and prevention of lens opacity[J].Cells,2022,11(19):3021.
|
[54] |
Zhang C,Chen M,Zhou N,et al.Metformin prevents H2O2-induced senescence in human lens epithelial B3 cells[J].Med Sci Monit Basic Res,2020,26:e923391.
|
[55] |
Fu Y,Wu R,Dong S,et al.Metformin protects human lens epithelial cells from high glucose-induced senescence and autophagy inhibition by upregulating SIRT1[J].Graefes Arch Clin Exp Ophthalmol,2024,262(2):477-485.
|
[56] |
Chen M,Fu Y,Wang X,et al.Metformin protects lens epithelial cells against senescence in a naturally aged mouse model[J].Cell Death Discov,2022,8(1):8.
|
[57] |
Chen Y,Wu T,Ho C,et al.Blocking of SGLT2 to eliminate NADPH-induced oxidative stress in lenses of animals with fructose-induced diabetes mellitus[J].Int J Mol Sci,2022,23(13):7142.
|