Home    中文  
 
  • Search
  • lucene Search
  • Citation
  • Fig/Tab
  • Adv Search
Just Accepted  |  Current Issue  |  Archive  |  Featured Articles  |  Most Read  |  Most Download  |  Most Cited

Chinese Journal of Ophthalmologic Medicine(Electronic Edition) ›› 2024, Vol. 14 ›› Issue (04): 252-256. doi: 10.3877/cma.j.issn.2095-2007.2024.04.011

• Review • Previous Articles    

Advances on the effects of metformin on age-related cataract

Jiaxi Li1, Ziyuan Liu2, Xuemin Li2,()   

  1. 1.Eight-year program 2017,Peking University Third Hospital,Beijing 100191,China
    2.Department of Ophthalmology,Peking University Third Hospital,Beijing Key Laboratory of Restoration of Damaged Ocular Nerve,Beijing 100191,China
  • Received:2024-07-19 Online:2024-08-28 Published:2025-01-14
  • Contact: Xuemin Li

Abstract:

Metformin is the first-line drug for the treatment of type 2 diabetes at present.It has been demonstrated that metformin also has other effects such as anti-aging,anti inflammatory,anti-cancer,weight loss,and cardiovascular protection.Disruption of oxidative stress homeostasis is an important mechanism in age-related cataracts,and the antioxidant stress mechanism of metformin is also considered to play a role in preventing cataract.The effects of metformin on lens aging of the age-related cataract was reviewed from the aspect of oxidative metabolism of crystalline lens,the pathogenesis of cataracts and the protective role of metformin in lens aging with the aim of providing new ideas for the clinical management of cataract.

Key words: Metformin, Prevention, Cataract, Oxidative stress

Copyright © Chinese Journal of Ophthalmologic Medicine(Electronic Edition), All Rights Reserved.
Tel: 0086-10-58269646 E-mail: zhykyxzz@163.com
Powered by Beijing Magtech Co. Ltd