The principle and application progress of visual cortex plasticity in visual impairment

doi:10.3877/cma.j.issn.2095-2007.2023.04.006

Abstract

Abstract:

The patients with advanced visual impairment have seriously affecting the quality of life with little effective treatment at present. In recent years, it has been demonstrated that the brain would automatically adapt its function and structure to recover visual function by visual cortex plasticity after visual impairment, which provides the possibility for visual recovery. Microperimetry biofeedback training, non-invasive brain stimulation and enriching environment can promote visual reshaping for patients with visual impairment. However, the principle of visual cortex plasticity has not been determined yet, and its application is still limited. The theoretical basis and recent application of visual cortex plasticity were reviewed in order to provide new therapeutic ideas for patients with visual impairment.

Key words: Neuroplasticity, Visual cortex plasticity, Vision impairment, Visual rehabilitation

Jie Zhou, Qianyin Chen, Jinglin Zhang. The principle and application progress of visual cortex plasticity in visual impairment[J]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2023, 13(04): 221-225.

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References 58

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第一作者(年份)	研究设计	分组	治疗方法	方案	改善的指标
Schatz等^[45](2016)	前瞻性、随机及部分盲	对照组20例，150%EPT组15例，200%EPT组17例	ACS	每周一次，每次30 min(20 Hz交流电)，持续52周	视野丢失速度和视网膜电图b波
Ratra等^[42](2018)		AMD 10例，STGD 4例，MS 2例，CNV 2例，近视性MD1例	MBFT	隔日一次，每次10 min，训练10次	视力、视网膜敏感度、固视稳定性及低视力临床生活表得分
Melillo等^[39](2020)	单中心、部分盲及随机对照	干预组12例，对照组12例	MBFT	每周一次，每次10 min，训练12次	V1激活、BCVA、黄斑敏感度及固视稳定性
Sahli等^[41](2020)	回顾性	AMD17例，STGD14例，CD4例	MBFT	隔日一次，每次10 min，训练10次	BCVA、阅读准确性、视功能问卷总分、近活动度评分及固视稳定性
El－Nahas等^[44](2021)	前瞻性、随机、双盲及病例对照	脑卒中继发VFD干预组21例，对照组11例	TMS	隔日一次，每次580 s(由1000次频率为10 Hz的脉冲组成)，训练16次	平均偏差、视野指数及视功能问卷评分
Räty等^[48](2021)	随机、双盲、假对照及三臂	(1)脑卒中偏盲ACS8例，ACS联合DCS8例，对照组8例；(2)ACS9例，对照组9例；(3)DCS7例，对照组7例	ACS，DCS	每天一次，每次20~40 min，持续2周(不计周末)	单独用ACS组与ACS+DCS组较对照组无差异，单用DCS改善患者视野，ACS改善黄斑敏感度
Qian等^[40](2022)	前瞻性	AMD7例，近视性MD10例	MBFT	每周两次，每次10 min，持续20周	视力、阅读速度、平均中心敏感度、固视稳定性及视功能问卷评分

第一作者(年份)	研究设计	分组	治疗方法	方案	改善的指标
Schatz等^[45](2016)	前瞻性、随机及部分盲	对照组20例，150%EPT组15例，200%EPT组17例	ACS	每周一次，每次30 min(20 Hz交流电)，持续52周	视野丢失速度和视网膜电图b波
Ratra等^[42](2018)		AMD 10例，STGD 4例，MS 2例，CNV 2例，近视性MD1例	MBFT	隔日一次，每次10 min，训练10次	视力、视网膜敏感度、固视稳定性及低视力临床生活表得分
Melillo等^[39](2020)	单中心、部分盲及随机对照	干预组12例，对照组12例	MBFT	每周一次，每次10 min，训练12次	V1激活、BCVA、黄斑敏感度及固视稳定性
Sahli等^[41](2020)	回顾性	AMD17例，STGD14例，CD4例	MBFT	隔日一次，每次10 min，训练10次	BCVA、阅读准确性、视功能问卷总分、近活动度评分及固视稳定性
El－Nahas等^[44](2021)	前瞻性、随机、双盲及病例对照	脑卒中继发VFD干预组21例，对照组11例	TMS	隔日一次，每次580 s(由1000次频率为10 Hz的脉冲组成)，训练16次	平均偏差、视野指数及视功能问卷评分
Räty等^[48](2021)	随机、双盲、假对照及三臂	(1)脑卒中偏盲ACS8例，ACS联合DCS8例，对照组8例；(2)ACS9例，对照组9例；(3)DCS7例，对照组7例	ACS，DCS	每天一次，每次20~40 min，持续2周(不计周末)	单独用ACS组与ACS+DCS组较对照组无差异，单用DCS改善患者视野，ACS改善黄斑敏感度
Qian等^[40](2022)	前瞻性	AMD7例，近视性MD10例	MBFT	每周两次，每次10 min，持续20周	视力、阅读速度、平均中心敏感度、固视稳定性及视功能问卷评分

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