Pay attention to the pathogenesis and prevention and control measures of posterior cataract

doi:10.3877/cma.j.issn.2095-2007.2023.04.001

Abstract

Abstract:

Posterior cataract (PCO) is the main complication after extracapsular cataract extraction and phacoemulsification. It has demonstrated that residual lens epithelial cell epithelial mesenchymal transition (EMT) after surgery is the main cause of PCO formation, and its pathogenesis involves the involvement of numerous signaling pathways, cytokines, growth factors, proteases, and integrins. The existing methods for preventing and controlling PCO include laser therapy, drug therapy, modification of intraocular lens (IOL) materials, and gene therapy. The current pathogenesis and prevention and control measures of posterior cataract were reviewed in this paper.

Key words: Posterior capsule opacification, Epithelial-to-mesenchymal transition, Drugs, Nanophase materials, Gene therapy

Xiuli Sun, Zhenyu Liu, Tingting Tang, Jingshang Zhang, Meng Li, Yingyan Mao, Xiuhua Wan. Pay attention to the pathogenesis and prevention and control measures of posterior cataract[J]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2023, 13(04): 193-198.

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