To investigate the efficacy of orbicularis oculi muscle joint muscles between the frontal muscle and injection of botulinum toxin A in the treatment of benign idiopathic blepharospasm.

Methods the clinical data of 40 patients (80 eyes) diagnosed with moderate and severe benign blepharospasm in the the Xinjiang Uygur Autonomous Region people's Hospital from June to December 2016 were analyzed retrospectively. Among them, the observation group was 20 cases (40 eyes), using botulinum toxin A injection for treatment, the eye orbicularis muscle; the control group of 20 cases (40 eyes), using botulinum toxin A injection for treatment, eye orbicularis, corrugator and procerus and the amount of muscle. The therapeutic efficacy was evaluated at the end of the injection treatment. The therapeutic effects were divided into complete remission, significant remission, partial remission and no remission. According to the scoring method of facial wrinkles, the score of the wrinkles was quantified. There were no wrinkles in 0, 1 for mild wrinkles, 2 for moderate wrinkles, 3 for moderate and severe wrinkles, and 4 for severe wrinkles. A test was used t for the comparison of botulinum toxin type . The effect of treatment and facial wrinkles score test by comparison with Kruskal-Wallis H. The comparison between the groups of upper eyelid ptosis was made by chi square test.

The observation group of botulinum toxin type A dosage (40±2.5) U , the control group of botulinum toxin A was (32±2.5) U, the difference between the two groups was statistically significant (t =10.12, P<0.05). The observation group complete remission, partial remission and relieve rate were 60%, 20% and 20%; the control group were 75%, 20% and 5%, evaluate the effects of the two groups were tested (Hc=-1.18, P>0.05), the difference was not statistically significant. The observation group appeared different degree of ptosis in 3 cases, the control group of 1 cases, there was no significant difference between the two groups comparison of facial wrinkles score in the observation group and control group, the control group was higher than that of the ob(χ² =-1.18, P>0.05); servation group (Hc=-5.49, P<0.05) two the difference was statistically significant (Hc = 5.49, P<0.05).

Compared with the choice of botulinum neurotoxin alone in the orbicularis oculi muscle, the treatment of botulinum toxin type A in the orbicularis oculi muscle, the orbicularis oculi muscle, the descending eyebrow muscle and the frontal muscle was more effective in the treatment of botulinum toxin type A.