Advances on the role of proteomics in diabetes-related eye diseases

doi:10.3877/cma.j.issn.2095-2007.2024.06.010

Abstract

Abstract:

Proteomics is a discipline that focuses on the pathogenesis，early diagnosis，targeted treatment and prognosis of diseases.In recent years，with the development and maturity of proteomics technology，its application in diabetes and its complications is becoming more and more extensive.Diabetic eye diseases include diabetic retinopathy（DR），diabetic macular edema（DME），diabetic dry eye，diabetic cataract and neovascular glaucoma（NVG）.The role of proteomics in the pathogenesis，diagnosis and biomarkers of diabetes-related eye diseases were reviewed in this paper.

Key words: Proteomics, Diabetes, Eye disease

Yutong Han, Ning Din, Xia Wu, Lizhen Gan, Zhengguo Chen, Yunchuan Wu, Qingbo Wei. Advances on the role of proteomics in diabetes-related eye diseases[J]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2024, 14(06): 375-379.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhykyxzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2095-2007.2024.06.010

https://zhykyxzz.cma-cmc.com.cn/EN/Y2024/V14/I06/375

References 55

［1］	International Diabetes Federation.IDF Diabetes Atlas，10th edn［EB/OL］.（2021-9-12）［2022-3-17］.https：//www.diabetesatlas.org.
［2］	中华医学会糖尿病学分会.中国2型糖尿病防治指南（2020年版）［J］.中华糖尿病杂志，2021，13（4）：315-409.
［3］	卫军营，钱小红.蛋白质组学研究技术进展［J］.中华检验医学杂志，2009，32（2）：137-141.
［4］	Zhan X，Li B，Zhan X，et al.Innovating the concept and practice of two-dimensional gel electrophoresis in the analysis of proteomes at the proteoform level［J］.Proteomes，2019，7（4）：36.
［5］	韦庆波，高卫萍，赵凡，等.蛋白质组学在干眼症研究中的应用进展［J］.辽宁中医杂志，2019，46（2）：429-431.
［6］	韦庆波，丁宁，杨小存，等.蛋白质组学技术在干眼研究及针刺治疗干眼中的应用［J］.国际眼科杂志，2024，24（1）：58-61.
［7］	许光军，张学东.蛋白质组学在糖尿病视网膜病变中的应用［J］.眼科新进展，2011，31（4）：391-393.
［8］	肖迎，唐仕波.视网膜疾病的蛋白质组研究［J］.中华眼底病杂志，2005，21（3）：199-202.
［9］	张凤.蛋白质组学核心技术研究综述［J］.延安职业技术学院学报，2014，28（5）：137-139.
［10］	黄啸.生物信息学在蛋白质组学上的应用［J］.安徽农业科学，2006，34（23）：6142-6144.
［11］	白建瑞.基于生物质谱技术的蛋白质组学研究［J］.现代农业研究，2023，29（4）：145-147.
［12］	Chen G，Yang L，Liu G，et al.Research progress in protein microarrays：Focussing on cancer research［J］.PROTEOMICSClinical Applications，2023，17（1）：2200036.
［13］	杜长虹，刘银萍.糖尿病视网膜病变发病机制研究进展［J］.沈阳医学院学报，2023，25（1）：88-91.
［14］	Yau JWY，Rogers SL，Kawasaki R，et al.Global prevalence and major risk factors of diabetic retinopathy［J］.Diabetes Care，2012，35（3）：556-564.
［15］	张媛，金玮，杨安怀.蛋白质组学应用于糖尿病视网膜病变发病机制的研究进展［J］.临床眼科杂志，2017，25（6）：569-572.
［16］	Ma JYW，Sze YH，Bian JF，et al.Critical role of mass spectrometry proteomics in tear biomarker discovery for multifactorial ocular diseases（Review）［J］.Int J Mol Med，2021，47（5）：83.
［17］	CsöszÉ，Boross P，Csutak A，et al.Quantitative analysis of proteins in the tear fluid of patients with diabetic retinopathy［J］.J Proteomics，2012，75（7）：2196-2204.
［18］	Xiao H，Xin W，Sun LM，et al.Comprehensive proteomic profiling of aqueous humor proteins in proliferative diabetic retinopathy［J］.Transl Vis Sci Technol，2021，10（6）：3.
［19］	Chiang SY，Tsai ML，Wang CY，et al.Proteomic analysis and identification of aqueous humor proteins with a pathophysiological role in diabetic retinopathy［J］.J Proteomics，2012，75（10）：2950-2959.
［20］	Chen H，Qiu B，Gao G，et al.Proteomic changes of aqueous humor in proliferative diabetic retinopathy patients treated with different intravitreal anti-VEGF agents［J］.Exp Eye Res，2022，216：108942.
［21］	Youngblood H，Robinson R，Sharma A， et al.Proteomic biomarkers of retinal inflammation in diabetic retinopathy［J］.Int J Mol Sci，2019，20（19）：4755.
［22］	Liu YP，Hu SW，Wu ZF，et al.Proteomic analysis of human serum from diabetic retinopathy［J］.Int J Ophthalmol，2011，4（6）：616.
［23］	Mishra D， Gade S， Glover K， et al.Vitreous humor：composition，characteristics and implication on intravitreal drug delivery［J］.Curr Eye Res，2023，48（2）：208-218.
［24］	Monteiro JP，Santos FM，Rocha AS，et al.Vitreous humor in the pathologic scope：insights from proteomic approaches［J］.Proteomics Clin Appl，2015，9（1-2）：187-202.
［25］	Balaiya S，Zhou Z，Chalam KV.Characterization of vitreous and aqueous proteome in humans with proliferativediabetic retinopathy and its clinical correlation［J］.Proteomics Insights，2017，PMID：28469465.
［26］	李琦，张雯，张学东.增殖性糖尿病视网膜病变伴重度黄斑水肿玻璃体蛋白质组学初步研究［J］.重庆医科大学学报，2010，35（7）：1043-1047.
［27］	Alanazi AH，Shan S， Narayanan SP， et al.Comparative proteomic analysis of type 2 diabetic versus non-diabetic vitreous fluids［J］.Life，2024，14（7）：883.
［28］	Raposo G，Stahl PD.Extracellular vesicles-on the cusp of a new language in the biological sciences［J］.EVCNA，2023，4（2）：240.
［29］	Guo W，Liu W，Wang J，et al.Extracellular vesicles and macrophages in tumor microenvironment：Impact on cervical cancer［J］.Heliyon，2024，10（15）：1-12
［30］	Wang S，Xia K，Zhu X，et al.Separation of high-purity plasma extracellular vesicles for investigating proteomic signatures in diabetic retinopathy［J］.JChromatogr A，2024，1718：464700.
［31］	Xiao J，Zhang H，Yang F，et al.Proteomic analysis of plasma sEVs reveals that TNFAIP8 is a new biomarker of cell proliferation in diabetic retinopathy［J］.J Proteome Res，2021，20（3）：1770-1782.
［32］	Chee CS，Chang KM，Loke MF，et al.Association of potential salivary biomarkers with diabetic retinopathy and its severity in type-2 diabetes mellitus： a proteomic analysis by mass spectrometry［J］.Peer J，2016，4：e2022.
［33］	杨维佳，贾俊，万鹏飞.活血利水方加减联合西药治疗糖尿病视网膜病变黄斑囊样水肿疗效观察［J］.四川中医，2023，41（7）：118-120.
［34］	Zhang J，Zhang J，Zhang C，et al.Diabetic macular edema：current understanding，molecular mechanisms and therapeutic implications［J］.Cells，2022，11（21）：3362.
［35］	Chen E，Looman M，Laouri M，et al.Burden of illness of diabetic macular edema：literature review［J］.Curr Med Res Opin，2010，26（7）：1587-1597.
［36］	Otani T，Kishi S，Maruyama Y.Patterns of diabetic macular edema with optical coherence tomography［J］.Am JOphthalmol，1999，127（6）：688-693.
［37］	Romero-Aroca P，Baget-Bernaldiz M，Pareja-Rios A，et al.Diabetic macular edema pathophysiology： vasogenic versus inflammatory［J］.JProteome Res，2016，2016（1）：2156273.
［38］	Zhang Y，Xu M，He H，et al.Proteomic analysis of aqueous humor reveals novel regulators of diabetic macular edema［J］.Exp Eye Res，2024，239：109724.
［39］	Ma IH，Hsieh YT，Pan SH.Explore the specific biomarkers for diabetic macular edema：a comparison study of tear proteomics［J］.Investig Ophthalmol Vis Sci，2024，65（7）：3325-3325.
［40］	张思伟，沈咏梅，叶山东，等.玻璃酸钠联合0.1%氟米龙治疗糖尿病性干眼症观察［J］.临床眼科杂志，2019，27（5）：454-457.
［41］	李泽楠，张宏.糖尿病性干眼发病机制的研究进展［J］.中国医药科学，2024，14（6）：59-63.
［42］	韦庆波，林佳，顾嘉凌，等.针灸治疗干眼症的临床与机制研究现状［J］.中华中医药杂志，2021，36（1）：319-323.
［43］	Zou X，Wang S，Zhang P，et al.Quantitative proteomics and weighted correlation network analysis of tear samples in adults and children with diabetes and dry eye［J］.Transl Vis Sci Technol，2020，9（13）：8.
［44］	Saxena S，Mitchell P，Rochtchina E.Five-year incidence of cataract in older persons with diabetes and pre-diabetes［J］.Ophthalmic Epidemiol，2004，11（4）：271-277.
［45］	Kiziltoprak H，Tekin K，Inanc M，et al.Cataract in diabetes mellitus［J］.World J Diabetes，2019，10（3）：140.
［46］	Chan LKY，Lin SS，Chan F，et al.Optimizing treatment for diabetic macular edema during cataract surgery［J］.Front Endocrinol（Lausanne），2023，14：1106706.
［47］	郭俊豪.糖尿病性白内障患者血糖指标水平［J］.吉林医学，2022，43（11）：2961-2963.
［48］	Xu W，Liang Y，Zhu Y，et al.Proteomic study of aqueous humour in diabetic patients with cataracts by TMT combined with HPLC-MS/MS［J］.BMC Ophthalmol，2023，23（1）：435.
［49］	Chang WC，Lee CH，Chiou SH，et al.Proteomic analysis of aqueous humor proteins in association with cataract risks：Diabetes and smoking［J］.JClin Med，2021，10（24）：5731.
［50］	郭鑫，苏胜，刘平.1型和2型糖尿病性白内障和正常晶状体的蛋白质组学分析［J］.哈尔滨医科大学学报，2015，49（4）：313-316.
［51］	Nagai N，Yamamoto T，Mitamura K，et al.Proteomic profile of the lens in a streptozotocin induced diabetic rat model using shotgun proteomics［J］.Biomedical Reports，2017，7（5）：445-450.
［52］	Tang Y，Shi Y，Fan Z.The mechanism and therapeutic strategies for neovascular glaucoma secondary to diabetic retinopathy［J］.Front Endocrinol，2023，14：1102361.
［53］	Madsen PH.Haemorrhagic glaucoma.Comparative study in diabetic and nondiabetic patients［J］.Br J Ophthalmol，1971，55（7）：444-450.
［54］	Lee P，Wang CC，Adamis AP.Ocular neovascularization：an epidemiologic review［J］.Surv Ophthalmol，1998，43（3）：245-269.
［55］	Wang Y，Xu S，Li J，et al.Proteomic analysis of aqueous humor proteins associated with neovascular glaucoma secondary to proliferative diabetic retinopathy［J］.Current Proteomics，2021，18（5）：717-729.

[1]	Wenjia Cao, Xuebing Liu, Anguo Luo, Shimin Zhong, Lan Deng, Yulin Wang, Zhaohuan Li. Evaluation of wall shear stress of the carotid artery by ultrasound vector flow imaging in patients with type 2 diabetes mellitus [J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2024, 21(07): 709-717.
[2]	Yiming Fei, Zhuo Liu, Lijuan Zhang. Current research status of omics analysis in the molecular mechanism of preterm birth [J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2024, 20(05): 504-510.
[3]	Zhigang Xu, Tao Cao, Ting He, Boao Li, Jingtao Wei, Dongliang Zhang, Hao Guan, Xuekang Yang. Clinical effect of antibiotic bone cement in the treatment of sternal osteomyelitis after cardiac surgery for patients with diabetes mellitus [J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2024, 19(06): 498-502.
[4]	Han Zhou, Huwen Wu, Peishen Zhang, Hanbing Deng, Wenxuan Fan, Jiacheng Li, Shaowen Cheng. Research progress of proteomics in chronic non healing wounds [J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2024, 19(06): 536-540.
[5]	Lingkai Meng, Dayong Li, Ning Wang, Guiming Wang, Bingnan Zhang, Ruotong Li, Lifeng Pan. Effect and mechanism of sleeve gastrectomy on obese rats with type 2 diabetes mellitus [J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2024, 18(06): 638-642.
[6]	Meng Li, La Jiang, Lei Dong, Qing Wu, Ben Li Jia. Clinical study of laparoscopic gastric sleeve resection in the treatment of obesity complicated with type 2 diabetes mellitus and fatty pancreas [J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2024, 18(05): 554-557.
[7]	Puzhao Liang, Yuyi Wu, Zhentao Tian. A case report of diabetes secondary left perinephric abscess with splenic abscess and pleural effusion [J]. Chinese Journal of Endourology(Electronic Edition), 2025, 19(01): 116-119.
[8]	Yuhan Yuan, Shengli Yang. Research progress in proteomic analysis of body fluids and tissues in early molecular diagnosis of liver cancer [J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2024, 13(06): 883-888.
[9]	Hongxia Yan, Xiaojuan Wang, Yixun Zhang. The effect of type 2 diabetes on tumor markers， clinicopathology and prognosis in patients with colorectal cancer [J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2024, 13(06): 483-487.
[10]	Junxia Du, Xiaolin Zhao, Haoran Wang, Zhiyuan Gao, Manqian Wang, Nanxi Wan, Dong Zhang, Xiaonan Ding, Qinqin Ren, Yingjie Duan, Li Tang, Hanyu Zhu. High throughput sequencing analysis of intestinal microbiome in hemodialysis patients with type 2 diabetes [J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2024, 13(06): 313-320.
[11]	Zhenzhen Ji, Zhijian Li. New advances in research on caspase-1-mediated pyroptosis in the field of ophthalmology [J]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2024, 14(05): 310-315.
[12]	Han Liu, Lanyue Zhang, Qiang Shen, Yanhong Fang, Shuang Zhou. Research progress in the correlation between transforming growth factor beta and diabetic retinopathy [J]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2024, 14(05): 316-320.
[13]	Xuan Wang, ·Nijiati Nazhakaiti, Yangyang Luo, Sheng Jiang. Correlation between skin levels of advanced glycation end products and risk of microvascular complications in patients with type 2 diabetes mellitus [J]. Chinese Journal of Clinicians(Electronic Edition), 2024, 18(05): 447-454.
[14]	Xing Wang, Yuan Chen, , Wusman Rezi Wan Guli, Yanying Guo. Co-pathogenic genes and potential common molecular mechanisms of type 2 diabetes mellitus, obesity, nonalcoholic steatohepatitis, and polycystic ovary syndrome [J]. Chinese Journal of Clinicians(Electronic Edition), 2024, 18(05): 481-490.
[15]	Xiaoming Wu, Yangkui Zhai, Juan Wang, Shuo Zhang, Jie Xu, Congqing Pan. Association of fasting c-peptide and quantitative insulin sensitivity index with arteriosclerosis index of plasma in male patients with T2DM [J]. Chinese Journal of Obesity and Metabolic Diseases(Electronic Edition), 2024, 10(04): 288-294.

Please choose a citation manager

Content to export