Pay attention to the role of lens protein aggregation in the formation of cataracts

doi:10.3877/cma.j.issn.2095-2007.2024.01.001

Abstract

Abstract:

Cataract is one of the common blinding eye diseases worldwide. According to the 2019 World Vision Report released by the World Health Organization, approximately 65.2 million patients worldwide suffer from cataracts, which can lead to moderate to severe visual impairment or even blindness. In recent years, with the acceleration of global population aging, the incidence of cataracts has sharply increased. The main component of the lens is crystalline protein, which can be divided into three major families of crystalline proteins, including α-lens protein β-lens protein and γ-lens protein. These proteins interact with each other with a high degree of orderliness, which is crucial for maintaining the transparency of the lens. If the interactions within or between proteins are disrupted, this subtle structure will be altered to expose hydrophobic surfaces, which can lead to the aggregation of crystalline proteins and the formation of cataracts. The interactions and aggregation mechanisms between crystalline proteins have been demonstrated in the furture, which can help elucidate the molecular pathological mechanisms of cataract formation, and aid in the development of preventive measures or targeted drugs for cataracts. The research progress on the role of lens protein aggregation in cataract formation in recent years were reviewed in this paper.

Key words: Crystallin, Cataract, Crystallin aggregation, Treatment

Yue Wang, Xiuhua Wan. Pay attention to the role of lens protein aggregation in the formation of cataracts[J]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2024, 14(01): 1-5.

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