Research progress of Dickkopf-1 in ocular fibrosis

doi:10.3877/cma.j.issn.2095-2007.2022.06.008

Abstract

Abstract:

Fibrosis is an important process of tissue damage and repair, while excessive fibrosis often leads to structural destruction and functional loss of organs. Wnt signal pathway (WNT) maintains homeostasis in organs and tissues by regulating cell proliferation, renewal and apoptosis in the body, while its over-activation leads to fibrosis in the body. Dickkopf-associated protein (DKK) is an endogenous regulatory protein of WNT. Dickkopf-associated protein 1 (DKK1) inhibits the development of various ocular fibrosis diseases by competing with WNT receptors. The role of DKK1 in the healing of corneal fibers, the occurrence of post-cataract, the progress of fundus fibrosis and pathological myopia were reviewed in this paper.

Key words: Dickkopf-1, WNT signaling pathway, Fibrosis, Treatment

Yu Song, Xiuli Bao. Research progress of Dickkopf-1 in ocular fibrosis[J]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2022, 12(06): 362-366.

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URL: https://zhykyxzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2095-2007.2022.06.008

https://zhykyxzz.cma-cmc.com.cn/EN/Y2022/V12/I06/362

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