The role of M2 macrophage polarization in the pathogenesis of allergic conjunctivitis involving TSLP and its downstream molecules

doi:10.3877/cma.j.issn.2095-2007.2022.04.008

Abstract

Abstract:

Allergic conjunctivitis is a common allergic disease of human ocular surface. The causes of this disease are very complicated, mainly an immune response mediated by IgE or T lymphocytes. At present, the molecular mechanism of the interaction between cytokines in anaphylactic effect stage has been clearly demonstrated, but the understanding of the upstream factors of allergy is relatively poor. It has been demonstrated that thymic stromal lymphopoietin (TSLP) is one of the upstream factors of allergy, which has priming and pro-allergenic effects. In addition, macrophages have also been found to play an important role in the Th2 dominant allergic inflammation by polarizing the M2 phenotype in the pollen-induced experimental allergic conjunctivitis mouse model. Currently, the mechanism of TSLP and M2 macrophages in the pathogenesis of allergic conjunctivitis is not well understood. The role of M2 macrophage polarization in the pathogenesis of allergic conjunctivitis involving TSLP and its downstream molecules was reviewed in this paper.

Key words: Allergic conjunctivitis, Thymic stromal lymphopoietin, M2 macrophages, Mechanism

Huan Gao, Xiaofen Zheng. The role of M2 macrophage polarization in the pathogenesis of allergic conjunctivitis involving TSLP and its downstream molecules[J]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2022, 12(04): 232-236.

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