Advances on the etiology and pathogenesis of iridocorneal endothelial syndrome

doi:10.3877/cma.j.issn.2095-2007.2021.06.009

Abstract

Abstract:

Iris corneal endothelial (ICE) syndrome is the general name of a group of ophthalmic diseases, including Chandler syndrome (CS), iris nevus syndrome (CRS) and progressive or substantial iris atrophy (PIA / EIA). ICE characterized by abnormal proliferation of corneal endothelial cells and migration to the iris surface. ICE progresses slowly and is incurable. It has been demonstrated that the possible etiology of ICE has been related with viral infection, and the formation and contraction of abnormal endothelial membrane has a widely recognized pathophysiological process. In this paper, the research status of the etiology and pathophysiological mechanism of ICE were reviewed.

Key words: Iridocorneal endothelial syndrome, Viral infection, Campbell membrane theory, Iridocorneal endothelial cell

Jiaxin Zhang, Jing Hong. Advances on the etiology and pathogenesis of iridocorneal endothelial syndrome[J]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2021, 11(06): 370-374.

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References 53

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年份	主要作者	主要成果	局限性
1986	Alvarado^[20,37]	根据既往研究结果首次提出病毒可能是导致病理学改变的病因	-
1990	Tsai^[32]	患者血清EBV抗体滴度升高；患者可能有细胞免疫异常，但没有体液免疫异常	过度匹配；局部异常需证据
1994	Alvarado^[9]	提出病毒感染假说；在角膜和房水中使用聚合酶链式反应检测到疱疹病毒的脱氧核糖核酸；超微结构研究未发现内皮细胞内存在病毒颗粒；病毒培养研究失败	只能说明相关，无法证明因果
1999	Groh^[38]	一例虹膜角膜内皮综合征患者，使用聚合酶链式反应在房水中检测到疱疹病毒的脱氧核糖核酸	样本量小
2018	Li^[39]	完善病毒感染假说	-
2020	Sutra^[35]	使用MDS技术检测患者房水和角膜组织获得阴性结果	样本量小

年份	主要作者	主要成果	局限性
1986	Alvarado^[20,37]	根据既往研究结果首次提出病毒可能是导致病理学改变的病因	-
1990	Tsai^[32]	患者血清EBV抗体滴度升高；患者可能有细胞免疫异常，但没有体液免疫异常	过度匹配；局部异常需证据
1994	Alvarado^[9]	提出病毒感染假说；在角膜和房水中使用聚合酶链式反应检测到疱疹病毒的脱氧核糖核酸；超微结构研究未发现内皮细胞内存在病毒颗粒；病毒培养研究失败	只能说明相关，无法证明因果
1999	Groh^[38]	一例虹膜角膜内皮综合征患者，使用聚合酶链式反应在房水中检测到疱疹病毒的脱氧核糖核酸	样本量小
2018	Li^[39]	完善病毒感染假说	-
2020	Sutra^[35]	使用MDS技术检测患者房水和角膜组织获得阴性结果	样本量小

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