Research progress of relation between Sjögren's syndrome and gut microbiota

doi:10.3877/cma.j.issn.2095-2007.2019.01.009

Abstract

Abstract:

The gut microbiota plays a critical role in the human immune system, and abnormalities of the intestinal flora and its metabolites are closely related to a series of systemic autoimmune diseases. Sj?gren's syndrome is one of the most common autoimmune disease whose onset may be relevant to a variety of factors. Over the recent years, emerging studies are suggesting that gut microbiota may be correlated with the occurrence or development of Sj?gren's syndrome, through profoundly affecting the local and systemic immune responses. This review describes the gut microbiota changes in patients with Sj?gren's syndrome, as well as itseffects on the disease and the possible immunological pathogenesis.

Key words: Gut microbiota, Sj?gren's syndrome, Autoimmunity

Yushi Liu, Xiaodan Jiang, Ran Hao, Xuemin Li. Research progress of relation between Sjögren's syndrome and gut microbiota[J]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2019, 09(01): 56-60.

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