Research Progress on the correlation of key immune negative regulating factors such as Treg cells and autoimmune uveitis

doi:10.3877/cma.j.issn.2095-2007.2018.02.005

Abstract

Abstract:

Uveitis is a more common inflammatory blind eye disease caused by autoimmune disorders. At present, scholars at home and abroad have found that uveitis is mainly mediated by CD4+ T cells. CD4+ T cells were mainly divided into four subsets, including helper T cells 1 (Th1), helper T2 cells (Th2), helper T cells 17 (Th17) and regulatory T cells (Treg). Previous studies were mainly focused on Th1, Th2 and Th17 cell subsets. In recent years, with the development of related research, scholars at home and abroad have found that Treg cells are the main factors in the negative regulation of uveitis. Treg cells can inhibit the immune response of self reactive T cells, inhibit the activation of traditional T cells and promote the secretion of some inhibitory cytokines, which play an important role in maintaining the occurrence of autoimmune diseases. Some scholars have found that Treg cells play a very important role in maintaining normal immune tolerance of the body. Its quantity and function changes are related to the development of many immune related diseases. In this paper, the research progress on the correlation between Treg cells and autoimmune uveitis (EAU) is reviewed.

Key words: Treg cells, Experimental autoimmune uveitis, Immune regulation

Li He, Jingsheng Yu. Research Progress on the correlation of key immune negative regulating factors such as Treg cells and autoimmune uveitis[J]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2018, 08(02): 76-81.

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