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中华眼科医学杂志(电子版) ›› 2026, Vol. 16 ›› Issue (03) : 164 -168. doi: 10.3877/cma.j.issn.2095-2007.2026.03.007

综述

视黄酸相关孤儿受体α的生物学功能及其在眼部疾病中的研究进展
王震宇, 王进达, 宋旭东()   
  1. 100730 首都医科大学附属北京同仁医院 北京同仁眼科中心 北京市眼科学与视觉科学重点实验室
  • 收稿日期:2026-03-27 出版日期:2026-06-28
  • 通信作者: 宋旭东
  • 基金资助:
    北京市自然科学基金项目(7264252)

Research progress on biological functions of retinoic acid related orphan receptor alpha in eye diseases

Zhenyu Wang, Jinda Wang, Xudong Song()   

  1. Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing Key Laboratory of Ophthalmology and Visual Science, Beijing 100730, China
  • Received:2026-03-27 Published:2026-06-28
  • Corresponding author: Xudong Song
引用本文:

王震宇, 王进达, 宋旭东. 视黄酸相关孤儿受体α的生物学功能及其在眼部疾病中的研究进展[J/OL]. 中华眼科医学杂志(电子版), 2026, 16(03): 164-168.

Zhenyu Wang, Jinda Wang, Xudong Song. Research progress on biological functions of retinoic acid related orphan receptor alpha in eye diseases[J/OL]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2026, 16(03): 164-168.

视黄酸相关孤儿受体(ROR)α是核受体超家族的重要成员,作为转录调控因子广泛参与氧化应激调控、线粒体功能维持、炎症与免疫稳态、脂质及能量代谢调控以及肿瘤的发生与发展等多种生物学过程。近年来的研究结果表明,RORα在分化角膜上皮等眼部组织稳态维持,以及年龄相关性黄斑变性、脉络膜黑色素瘤等多种眼部疾病的发生与发展中亦发挥重要作用。本文中笔者围绕RORα的主要生物学功能及其在眼部组织和眼部疾病中的研究进展进行综述,重点总结其在视网膜、葡萄膜及眼表相关疾病中的潜在调控作用,并探讨其作为眼科疾病新型分子靶点的研究价值和临床应用前景。

Retinoic acid-related orphan receptor alpha (RORα) is an important member of the nuclear receptor superfamily and functions as a transcriptional regulator involved in a wide range of biological processes, including oxidative stress regulation, maintenance of mitochondrial function, inflammatory and immune homeostasis, lipid and energy metabolism, as well as tumor initiation and progression. Emerging evidence in recent years has further demonstrated that RORα plays critical roles in maintaining ocular tissue homeostasis, such as corneal epithelial differentiation, and participates in the pathogenesis of several ocular diseases, including age-related macular degeneration and uveal melanoma. The major biological functions of RORα and recent advances in understanding its roles in ocular tissues and ocular diseases were summarized in this paper. Particular emphasis was placed on the potential regulatory functions of RORα in retinal, uveal, and ocular surface-related disorders. In addition, the research value of RORα as a novel molecular target and its potential clinical implications in ophthalmic diseases were discussed.

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