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中华眼科医学杂志(电子版) ›› 2024, Vol. 14 ›› Issue (05) : 310 -315. doi: 10.3877/cma.j.issn.2095-2007.2024.05.010

综述

含半胱氨酸的天冬氨酸蛋白水解酶1介导细胞焦亡在眼科领域的研究进展
姬震震1, 李志坚1,()   
  1. 1.150000 哈尔滨医科大学附属第一临床医学院眼科医院2022级硕士研究生
  • 收稿日期:2024-08-08 出版日期:2024-10-28
  • 通信作者: 李志坚
  • 基金资助:
    国家自然科学基金项目(81870643)

New advances in research on caspase-1-mediated pyroptosis in the field of ophthalmology

Zhenzhen Ji1, Zhijian Li1,()   

  1. 1.Department of Ophthalmology,First Affiliated Hospital of Harbin Medical University,Harbin 150000,China
  • Received:2024-08-08 Published:2024-10-28
  • Corresponding author: Zhijian Li
引用本文:

姬震震, 李志坚. 含半胱氨酸的天冬氨酸蛋白水解酶1介导细胞焦亡在眼科领域的研究进展[J/OL]. 中华眼科医学杂志(电子版), 2024, 14(05): 310-315.

Zhenzhen Ji, Zhijian Li. New advances in research on caspase-1-mediated pyroptosis in the field of ophthalmology[J/OL]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2024, 14(05): 310-315.

细胞焦亡是一种新型的程序性细胞死亡形式,其特征是由炎性半胱天冬酶(caspase)-1介导的细胞死亡。近年来,细胞焦亡在多种疾病发病机制中的作用受到广泛关注,在眼科疾病中的作用也逐渐显现。caspase-1通过组装核苷酸结合寡聚化结构域样受体蛋白3炎性小体被激活,进而切割GSDMD蛋白并诱导细胞膜形成孔洞,导致细胞肿胀破裂和促炎因子白细胞介素(IL)-1β及IL-18的释放引发细胞死亡,引起局部和全身性的炎症反应。现有研究结果表明,caspase-1介导的细胞焦亡与角膜炎、白内障、青光眼及年龄相关性黄斑变性等多种眼部疾病的发生和进展密切相关。本文中笔者对caspase-1介导的细胞焦亡在眼科领域的最新研究进展进行综述。

Pyroptosis is a new type of programmed cell death,which is characterized by cell death mediated by inflammatory caspase-1.In recent years,the role of pyroptosis in the pathogenesis of a variety of diseases has been widely concerned,and its role in eye diseases has gradually emerged.Caspase-1 is activated by assembling nucleotide binding oligomerization domain like receptor protein 3 inflammasome,which cleaves gsdmd protein and induces cell membrane to form holes,leading to cell swelling and rupture and the release of pro-inflammatory cytokines interleukin(IL)-1βand IL-18,leading to cell death,causing local and systemic inflammatory reactions.It has been demonstrated that caspase-1-mediated pyroptosis has been closely related to the occurrence and progress of a variety of eye diseases,such as keratitis,cataract,glaucoma and age-related macular degeneration.The latest research progress of caspase-1-mediated pyroptosis in the field of ophthalmology was reviewed in this paper.

图1 半胱天冬酶-1介导细胞焦亡的机制[21]
表1 细胞焦亡与坏死、凋亡、坏死性凋亡及铁死亡的区别
[1]
Boucher D,Monteleone M,Coll RC,et al.Caspase-1 selfcleavage is an intrinsic mechanism to terminate inflammasome activity[J].J Exp Med,2018,215(3):827-840.
[2]
Fan TJ,Han LH,Cong RS,et al.Caspase family proteases and apoptosis[J].Acta Biochim Biophys Sin(Shanghai),2005,37(11):719-727.
[3]
Wang H,Capell W,Yoon JH,et al.Obesity development in caspase-1-deficient mice[J].Int JObes(Lond),2014,38(1):152-155.
[4]
Miao EA,Ranan JV,Aderem A.Caspase-1-induced pyroptotic cell death[J].Immunol Rev,2011,243(1):206-214.
[5]
Mcilwain DR,Berger T,Mak TW.Caspase functions in cell death and disease[J].Cold Spring Harb Perspect Biol,2013,5(4):a008656.
[6]
Kumaresan V,Ravichandran G,Nizam F,et al.Multifunctional murrel caspase 1,2,3,8 and 9:Conservation,uniqueness and their pathogen-induced expression pattern[J].Fish Shellfish Immunol,2016,49:493-504.
[7]
Kostura MJ,Tocci MJ,Limjuco G,et al.Identification of a monocyte specific pre-interleukin 1 beta convertase activity[J].Proc Natl Acad Sci USA,1989,86(14):5227-5231.
[8]
Black RA,Kronheim SR,Merriam JE,et al.A pre-aspartatespecific protease from human leukocytes that cleaves prointerleukin-1 beta[J].J Biol Chem,1989,264(10):5323-5326.
[9]
Martinon F, Tschopp J.Inflammatory caspases and inflammasomes:master switches of inflammation[J].Cell Death Differ,2007,14(1):10-22.
[10]
Zhen H,Hu Y,Liu X,et al.The protease caspase-1:Activation pathways and functions[J].Biochemical and Biophysical Research Communications,2024,717:149978.
[11]
Martinon F,Burns K,Tschopp J.The inflammasome:a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta[J].Mol Cell,2002,10(2):417-426.
[12]
Zychlinsky A,Prevost MC,Sansonetti PJ.Shigella flexneri induces apoptosis in infected macrophages[J].Nature,1992,358(6382):167-169.
[13]
Chen Y,Smith MR,Thirumalai K,et al.A bacterial invasin induces macrophage apoptosis by binding directly to ICE[J].Embo j,1996,15(15):3853-3860.
[14]
D'souza CA,Heitman J.Dismantling the Cryptococcus coat[J].Trends Microbiol,2001,9(3):112-113.
[15]
李正阳,叶惠平,彭聪.细胞焦亡在头颈部鳞状细胞癌中的作用及其研究进展[J].中国耳鼻咽喉颅底外科杂志,2024,30(3):56-60.
[16]
Sollberger G,Strittmatter GE,Garstkiewicz M,et al.Caspase-1:The inflammasome and beyond[J].Innate Immunity,2013,20(2):115-125.
[17]
Yu P,Zhang X,Liu N,et al.Pyroptosis:mechanisms and diseases[J].Signal Transduction and Targeted Therapy,2021,6(1):128.
[18]
Barton GM,Medzhitov R.Toll-like receptor signaling pathways[J].Science,2003,300(5625):1524-1525.
[19]
Broz P,Dixit VM.Inflammasomes:mechanism of assembly,regulation and signalling[J].Nature Reviews Immunology,2016,16(7):407-420.
[20]
Bergsbaken T,Fink SL,Cookson BT.Pyroptosis:host cell death and inflammation[J].Nature Reviews Microbiology,2009,7(2):99-109.
[21]
余丹,陈鹏.NLRP3/caspase-1介导的细胞焦亡在动脉粥样硬化发生、发展中的作用[J].医学研究杂志,2024,53(4):10-14.
[22]
Majno G,Jpros I.Apoptosis,oncosis,and necrosis.An overview of cell death[J].Am J Pathol,1995,146(1):3-15.
[23]
Nikoletopoulou V,Markaki M,Palikaras K,et al.Crosstalk between apoptosis,necrosis and autophagy[J].Biochim Biophys Acta,2013,1833(12):3448-3459.
[24]
Savitskaya MA,Onishchenko GE.Mechanisms of Apoptosis[J].Biochemistry(Mosc),2015,80(11):1393-1405.
[25]
Bertheloot D,Latz E,Franklin BS.Necroptosis,pyroptosis and apoptosis:an intricate game of cell death[J].Cell Mol Immunol,2021,18(5):1106-1121.
[26]
Yan J,Wan P,Choksi S,et al.Necroptosis and tumor progression[J].Trends Cancer,2022,8(1):21-27.
[27]
Jiang X,Stockwell BR,Conrad M.Ferroptosis:mechanisms,biology and role in disease[J].Nat Rev Mol Cell Biol,2021,22(4):266-282.
[28]
ZemanováM.Dry eye disease.A review[J].Cesk Slov Oftalmol,2021,77(3):107-119.
[29]
Liao K,Zeng H,Yang X,et al.KCNK5 Regulating Potassium Efflux and Inducing Pyroptosis in Corneal Epithelial Cells Through TNFSF10-Mediated Autophagy in Dry Eye[J].Invest Ophthalmol Vis Sci,2024,65(1):34.
[30]
Chen H,Gan X,Li Y,et al.NLRP12-and NLRC4-mediated corneal epithelial pyroptosis is driven by GSDMD cleavage accompanied by IL-33 processing in dry eye[J].Ocul Surf,2020,18(4):783-794.
[31]
Li J,Yang K,Pan X,et al.Long Noncoding RNA MIAT Regulates Hyperosmotic Stress-Induced Corneal Epithelial Cell Injury via Inhibiting the Caspase-1-Dependent Pyroptosis and Apoptosis in Dry Eye Disease[J].J Inflamm Res,2022,15:3269-83.
[32]
Zhang J, Dai Y, Yang Y, et al.Calcitriol Alleviates Hyperosmotic Stress-Induced Corneal Epithelial Cell Damage via Inhibiting the NLRP3-ASC-Caspase-1-GSDMD Pyroptosis Pathway in Dry Eye Disease[J].J Inflamm Res,2021,14:2955-2962.
[33]
Lou Q,Pan L,Xiang S,et al.Suppression of NLRP3/Caspase-1/GSDMD Mediated Corneal Epithelium Pyroptosis Using Melatonin-Loaded Liposomes to Inhibit Benzalkonium Chloride-Induced Dry Eye Disease[J].Int J Nanomedicine,2023,18:2447-2463.
[34]
Cao X,Di G,Bai Y,et al.Aquaporin5 Deficiency Aggravates ROS/NLRP3 Inflammasome-Mediated Pyroptosis in the Lacrimal Glands[J].Invest Ophthalmol Vis Sci,2023,64(1):4.
[35]
Li X,Chen C,Chen Y,et al.Oridonin ameliorates ocular surface inflammatory responses by inhibiting the NLRP3/caspase-1/GSDMD pyroptosis pathway in dry eye[J].Exp Eye Res,2024,245:109955.
[36]
Clearfeld E,Muthappan V, Wang X, et al.Conjunctival autograft for pterygium[J].Cochrane Database Syst Rev,2016,2(2):Cd011349.
[37]
He S,Wu Z.Biomarkers in the Occurrence and Development of Pterygium[J].Ophthalmic Res,2022,65(5):481-492.
[38]
Baheran SS,Alany RG,Schwikkard S,et al.Pharmacological treatment strategies of pterygium:Drugs,biologics,and novel natural products[J].Drug Discov Today, 2023, 28(1):103416.
[39]
Ding P,Wang R,He Y.Risk factors for pterygium:Latest research progress on major pathogenesis[J].Exp Eye Res,2024,243:109900.
[40]
江华维,刘霞,王艳,等.翼状胬肉发病机制的研究进展[J].昆明医科大学学报,2023,44(1)144-150.
[41]
Sun N,Zhang H.Pyroptosis in pterygium pathogenesis[J].Biosci Rep,2018,38(3):BSR20180282.
[42]
Liu W,Tian X,Gu L,et al.Oxymatrine mitigates Aspergillus fumigatus keratitis by suppressing fungal activity and restricting pyroptosis[J].Exp Eye Res,2024,240:109830.
[43]
Gu L,Lin J,Wang Q,et al.Dimethyl fumarate ameliorates fungal keratitis by limiting fungal growth and inhibiting pyroptosis[J].Int Immunopharmacol,2023,115:109721.
[44]
Fang X,Lian H,Liu S,et al.A positive feedback cycle between the alarmin S100A8/A9 and NLRP3 inflammasome-GSDMD signalling reinforces the innate immune response in Candida albicans keratitis[J].Inflamm Res,2023,72(7):1485-1500.
[45]
Ji Q,Wang L,Liu J,et al.Aspergillus fumigatus-Stimulated Human Corneal Epithelial Cells Induce Pyroptosis of THP-1 Macrophages by Secreting TSLP[J].Inflammation,2021,44(2):682-692.
[46]
刘艳,余雨枫,易文琳,等.2015-2019年中国50岁以上人群白内障患病率的Meta分析[J].中国医学创新,2020,17(35):15-159.
[47]
徐靖杰,张颖,姚克,等.白内障发病机制与防治策略的研究进展[J].中国科学:生命科学,2022,52(12):1807-1814.
[48]
Jin X,Jin H,Shi Y,et al.Pyroptosis,a novel mechanism implicated in cataracts[J].Mol Med Rep,2018,18(2):2277-2285.
[49]
Jin X,Jin H,Shi Y,et al.Long Non-Coding RNA KCNQ1OT1 Promotes Cataractogenesis via miR-214 and Activation of the Caspase-1 Pathway[J].Cell Physiol Biochem,2017,42(1):295-305.
[50]
Sun Y,Rong X,Li D,et al.Down-regulation of CRTAC1 attenuates UVB-induced pyroptosis in HLECs through inhibiting ROSproduction[J].Biochem Biophys Res Commun,2020,532(1):159-165.
[51]
张竞月,冯康春,余雪琳,等.LncRNA MEG3对过氧化氢诱导人晶状体上皮细胞焦亡的机制研究[J].四川医学,2023,44(8):813-817.
[52]
李志坚.短波蓝光辐射下caspase-1/GSDMD通道介导的晶状体上皮细胞焦亡在白内障发生中的作用及其机制研究[D].哈尔滨医科大学,2018.
[53]
Zhao WJ,Fan CL,Hu XM,et al.Regulated Cell Death of Retinal Ganglion Cells in Glaucoma:Molecular Insights and Therapeutic Potentials[J].Cell Mol Neurobiol,2023,43(7):3161-3178.
[54]
Chen D,Miao S,Chen X,et al.Regulated Necrosis in Glaucoma:Focus on Ferroptosis and Pyroptosis[J].Mol Neurobiol,2024,61(5):2542-2555.
[55]
Zeng Z,You M,Rong R,et al.Translocator protein 18 kDa regulates retinal neuron apoptosis and pyroptosis in glaucoma[J].Redox Biol,2023,63:102713.
[56]
Wang F,Song Y, Liu P, et al.Rapamycin suppresses neuroinflammation and protects retinal ganglion cell loss after optic nerve crush[J].Int Immunopharmacol,2023,119:110171.
[57]
谢志.白藜芦醇调节视网膜缺血/再灌注损伤的细胞焦亡机制研究[D].南昌大学,2023.
[58]
雷苑,李丽萍,朱毅翔,等.空气污染物暴露通过硝化应激及细胞焦亡诱发青光眼及眼压升高[N].2023第二十三届国际眼科学学术会议,2023.
[59]
袁安琪.川芎嗪通过干预小胶质细胞活化和抑制细胞焦亡改善实验性青光眼视神经损伤[D].广州医科大学,2023.
[60]
Tan TE,Wong TY.Diabetic retinopathy:Looking forward to 2030[J].Front Endocrinol(Lausanne),2022,13:1077669.
[61]
Li W,Yang S,Chen G,et al.MiR-200c-3p regulates pyroptosis by targeting SLC30A7 in diabetic retinopathy[J].Hum Exp Toxicol,2022,41:9603271221099589.
[62]
廉艺童,刘志敏,聂辅娇,等.益肝明目汤对糖尿病视网膜水肿模型大鼠NLRP3/Caspase-1信号通路的影响[J].湖南中医药大学学报,2023,43(3):421-429.
[63]
来坚,李能,刘子彬,等.当归多糖促进lncRNA MEG3表达调控视网膜上皮细胞焦亡改善糖尿病视网膜病变作用机制研究[J].浙江中西医结合杂志,2023,33(7):592-599.
[64]
Zhou J,Qiu J,Song Y,et al.Pyroptosis and degenerative diseases of the elderly[J].Cell Death Dis,2023,14(2):94.
[65]
Fleckenstein M,Keenan TDL,Guymer RH,et al.Age-related macular degeneration[J].Nature Reviews Disease Primers,2021,7(1):31.
[66]
Sun HJ,Jin XM,Xu J,et al.Baicalin Alleviates Age-Related Macular Degeneration via miR-223/NLRP3-Regulated Pyroptosis[J].Pharmacology,2020,105(1-2):28-38.
[67]
毕鸿昊,郭惠怡,陈强.自噬与炎症小体相互作用对干性年龄相关性黄斑变性影响的研究进展[J].中国中医眼科杂志,2022,32(6):482-486.
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