切换至 "中华医学电子期刊资源库"

中华眼科医学杂志(电子版) ›› 2021, Vol. 11 ›› Issue (02) : 104 -108. doi: 10.3877/cma.j.issn.2095-2007.2021.02.008

综述

折叠式人工玻璃体球囊研究与应用的新进展
曾百卉1, 王倩1, 韩宁2, 隋桂琴2,()   
  1. 1. 130041 长春,吉林大学第二医院 2018级硕士研究生
    2. 130041 长春,吉林大学第二医院眼科诊疗中心眼底病科
  • 收稿日期:2020-08-08 出版日期:2021-04-28
  • 通信作者: 隋桂琴
  • 基金资助:
    吉林省财政厅卫生专项项目(20181731154)

New progress in research and application of foldable artificial vitreous balloon

Baihui Zeng1, Qian Wang1, Ning Han2, Guiqin Sui2,()   

  1. 1. Master′s degree 2018, The Second Hospital of Jilin University, Changchun 130041, China
    2. Department of Ophthalmology, The Second Hospital of Jilin University, Changchun 130041, China
  • Received:2020-08-08 Published:2021-04-28
  • Corresponding author: Guiqin Sui
引用本文:

曾百卉, 王倩, 韩宁, 隋桂琴. 折叠式人工玻璃体球囊研究与应用的新进展[J]. 中华眼科医学杂志(电子版), 2021, 11(02): 104-108.

Baihui Zeng, Qian Wang, Ning Han, Guiqin Sui. New progress in research and application of foldable artificial vitreous balloon[J]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2021, 11(02): 104-108.

折叠式人工玻璃体球囊(FCVB)是我国自主研发的新型玻璃体替代物,属于全球创新产品。折叠式人工玻璃体球囊由计算机模拟的具有玻璃体形态的球囊、引流管及引流阀组成,由改良性液体硅橡胶作为基本材料,具有良好的物理特性及生物相容性。在折叠植入眼内后,可在球囊内注入硅油、生理盐水或水凝胶等介质对视网膜起到360度的支撑作用。主要应用于严重视网膜脱离不能使用现有玻璃体替代物的患者或作为药物缓释系统使用。然而,FCVB目前临床应用较少,观察时间较短,仍存在一些有待改进的问题。

Foldable capsular vitreous body (FCVB) is an innovative vitreous substitute developed independently by China. It is a global innovative product, which is composed of a computer simulated capsule, a drainage tube and a drainage valve. FCVB′s material was made by modified liquid silicone rubber which has good physical properties and biocompatibility. FCVB could be filled with silicone oil, or balanced salt solution after folding intraocular implantation, providing a 360-degree fulfilled support. It is mainly used in patients with severe retinal detachment who can not be treated with existing vitreous substitutes. Additionally, some studies have confirmed that FCVB also could be used as a drug delivery device to release a variety of drugs, namely a novel combination of vitreous substitute and drug delivery system. FCVB has good application prospects, but there are still some problems, which need to be further studied and improved on such as the number of clinical applications being small, and investigate the effects of long-term application.

[1]
Gao Q, Mou S, Ge J, et al. A new strategy to replace the natural vitreous by a novel capsular artificial vitreous body with pressure-control valve[J]. Eye (Lond), 2008, 22(3): 461-468.
[2]
Liu Y, Jiang Z, Gao Q, et al. Technical standards of a foldable capsular vitreous body in terms of mechanical, optical, and biocompatible properties[J]. Artif Organs, 2010, 34(10): 836-845.
[3]
Chen J, Gao Q, Liu Y, et al. Clinical device-related article evaluation of morphology and functions of a foldable capsular vitreous body in the rabbit eye[J]. J Biomed Mater Res B Appl Biomater, 2011, 97(2): 396-404.
[4]
Chen H, Feng S, Liu Y, et al. Functional evaluation of a novel vitreous substitute using polyethylene glycol sols injected into a foldable capsular vitreous body[J]. J Biomed Mater Res A, 2013, 101(9): 2538-2547.
[5]
Mariacher S, Szurman P. Artificial vitreous body: Strategies for vitreous body substitutes[J]. Ophthalmologe, 2015, 112(7): 572-579.
[6]
Donati S, Caprani Sm, Airaghi G, et al. Vitreous substitutes: the present and the future[J]. Biomed Res Int, 2014: 351804.
[7]
Januschowski K, Seuthe AM, Boden KT, et al. Novel vitreous body replacement with hydrogel?[J]. Ophthalmologe, 2018, 115(8): 692-696.
[8]
Deuchler S, Ackermann H, Singh P, et al. Key Factors to Improve the Outcome of Retinal Reattachment Surgery in Proliferative Vitreoretinopathy and Proliferative Diabetic Retinopathy[J]. J Ophthalmol, 2017: 2323897.
[9]
Durand Ml. Bacterial and Fungal Endophthalmitis[J]. Clin Microbiol Rev, 2017, 30(3): 597-613.
[10]
Khan MA, Brady CJ, Kaiser RS. Clinical management of proliferative vitreoretinopathy: an update[J]. Retina, 2015, 35(2): 165-175.
[11]
Rejdak R, Juenemann AG, Natarajan S. Posterior Segment Ocular Trauma: Timing and Indications for Vitrectomy[J]. J Ophthalmol, 2017: 5250924.
[12]
Soman N, Banerjee R. Artificial vitreous replacements[J]. Biomed Mater Eng, 2003, 13(1): 59-74.
[13]
Chen Y, Kearns VR, Zhou L, et al. Silicone oil in vitreoretinal surgery: indications, complications, new developments and alternative long-term tamponade agents[J]. Acta Ophthalmol, 2020: 14604.
[14]
Pichi F, Hay S, Abboud EB. Inner retinal toxicity due to silicone oil: a case series and review of the literature[J]. Int Ophthalmol, 2020, 40(9): 2413-2422.
[15]
Branisteanu DC, Moraru AD, Maranduca MA, et al. Intraocular pressure changes during and after silicone oil endotamponade (Review)[J]. Exp Ther Med, 2020, 20(6): 204.
[16]
Nicolai M, Lassandro N, Franceschi A, et al. Intraocular Pressure Rise Linked to Silicone Oil in Retinal Surgery: A Review[J]. Vision (Basel), 2020, 4(3): 36.
[17]
Barca F, Caporossi T, Rizzo S. Silicone Oil: Different Physical Proprieties and Clinical Applications[J]. Journal of Biomedicine and Biotechnology, 2014: 502143.
[18]
Liu Z, Fu G, Liu A. The relationship between inflammatory mediator expression in the aqueous humor and secondary glaucoma incidence after silicone oil tamponade[J]. Exp Ther Med, 2017, 14(6): 5833-5836.
[19]
La CM, Lux A, Heegaard S. Visual loss under silicone oil[J]. Klin Monbl Augenheilkd, 2010, 227(3): 181-184.
[20]
Su X, Tan MJ, Li Z, et al. Recent Progress in Using Biomaterials as Vitreous Substitutes[J]. Biomacromolecules, 2015, 16(10): 3093-3102.
[21]
Steijns D, Stilma JS. Vitrectomy: in search of the ideal vitreous replacement[J]. Ned Tijdschr Geneeskd, 2009, 153(35): 433.
[22]
Cheng NX, Wang Yl, Wang JH, et al. Complications of breast augmentation with injected hydrophilic polyacrylamide gel[J]. Aesthetic Plast Surg, 2002, 26(5): 375-382.
[23]
Qiao Q, Wang X, Sun J, et al. Management for postoperative complications of breast augmentation by injected polyacrylamide hydrogel[J]. Aesthetic Plast Surg, 2005, 29(3): 156-161.
[24]
Benediktsson K, Perbeck L. Capsular contracture around saline-filled and textured subcutaneously-placed implants in irradiated and non-irradiated breast cancer patients: five years of monitoring of a prospective trial[J]. J Plast Reconstr Aesthet Surg, 2006, 59(1): 27-34.
[25]
Bingham HG, Copeland EM, Hackett R, et al. Breast cancer in a patient with silicone breast implants after 13 years[J]. Ann Plast Surg, 1988, 20(3): 236-237.
[26]
Glatt BS, Afifi G, Noone RB. Long-term follow-up of a sponge breast implant and review of the literature[J]. Ann Plast Surg, 1999, 42(2): 196-201.
[27]
Mirza RG, Johnson MW, Jampol LM. Optical Coherence Tomography Use in Evaluation of the Vitreoretinal Interface: A Review[J]. Survey of Ophthalmology, 2007, 52(4): 397-421.
[28]
Lin X, Ge J, Gao Q, et al. Evaluation of the flexibility, efficacy, and safety of a foldable capsular vitreous body in the treatment of severe retinal detachment[J]. Invest Ophthalmol Vis Sci, 2011, 52(1): 374-381.
[29]
Lin X, Wang Z, Jiang Z, et al. Preliminary efficacy and safety of a silicone oil-filled foldable capsular vitreous body in the treatment of severe retinal detachment[J]. Retina, 2012, 32(4): 729-741.
[30]
Schwartz SG, Flynn HW, Mieler WF. Update on retinal detachment surgery[J]. Current Opinion in Ophthalmology, 2013, 24(3): 255-261.
[31]
高前应. 折叠式人工玻璃体临床试用和生产[J]. 中国科技成果201321: 32-32.
[32]
Wang P, Gao Q, Jiang Z, et al. Biocompatibility and retinal support of a foldable capsular vitreous body injected with saline or silicone oil implanted in rabbit eyes[J]. Clin Exp Ophthalmol, 2012, 40(1): e67-e75.
[33]
Liu Y, Ke Q, Chen J, et al. Sustained mechanical release of dexamethasone sodium phosphate from a foldable capsular vitreous body[J]. Invest Ophthalmol Vis Sci, 2010, 51(3): 1636-1642.
[34]
Jiang Z, Wang P, Pan B, et al. Evaluation of levofloxacin release characteristics from a human foldable capsular vitreous body in vitro[J]. J Ocul Pharmacol Ther, 2012, 28(1): 33-40.
[35]
Wang T, Huang X, Gao Q, et al. A preliminary study to treat severe endophthalmitis via a foldable capsular vitreous body with sustained levofloxacin release in rabbits[J]. Invest Ophthalmol Vis Sci, 2013, 54(1): 804-812.
[36]
Chen X, Liu Y, Jiang Z, et al. Protein kinase Calpha downregulation via siRNA-PKCalpha released from foldable capsular vitreous body in cultured human retinal pigment epithelium cells[J]. Int J Nanomedicine, 2011, 6: 1303-1311.
[37]
Zheng H, Wang Z, Wang P, et al. Evaluation of 5-fluorouracil released from a foldable capsular vitreous body in vitro and in vivo[J]. Graefes Arch Clin Exp Ophthalmol, 2012, 250(5): 751-759.
[38]
Zhang R, Wang T, Xie C, et al. Evaluation of supporting role of a foldable capsular vitreous body with magnetic resonance imaging in the treatment of severe retinal detachment in human eyes[J]. Eye (Lond), 2011, 25(6): 794-802.
[39]
Wang P, Gao Q, Lin X, et al. Comprehensive analysis of inflammatory immune mediators of the intraocular fluid aspirated from the foldable capsular vitreous body filled-eyes[J]. PLoS One, 2012, 7(10): e46384.
[40]
Zhang X, Tian X, Zhang B, et al. Study on the effectiveness and safety of Foldable Capsular Vitreous Body implantation[J]. BMC Ophthalmol, 2019, 19(1): 260.
[41]
Yang W, Yuan Y, Zong Y, et al. Preliminary study on retinal vascular and oxygen-related changes after long-term silicone oil and foldable capsular vitreous body tamponade[J]. Sci Rep, 2014, 4: 25272.
[42]
Lin X, Sun X, Wang Z, et al. Three-Year Efficacy and Safety of a Silicone Oil-Filled Foldable-Capsular-Vitreous-Body in Three Cases of Severe Retinal Detachment[J]. Transl Vis Sci Technol, 2016, 5(1): 2.
[43]
Gao QY, Fu Y, Hui YN. Vitreous substitutes: challenges and directions[J]. Int J Ophthalmol, 2015, 8(3): 437-440.
[44]
Feng S, Chen H, Liu Y, et al. A novel vitreous substitute of using a foldable capsular vitreous body injected with polyvinylalcohol hydrogel[J]. Sci Rep, 2013, 3: 1838.
[45]
张贵森,巩慧,惠延年,等. 折叠式人工玻璃体球囊植入的初步临床实践[J]. 国际眼科杂志201818(3): 578-580.
[46]
郝琳娜,毕春潮,王睿. 折叠式人工玻璃体球囊的临床应用[J]. 临床眼科杂志201927(4): 331-333.
[47]
李晓丹,张百珂,贾雍,等. 折叠式人工玻璃体球囊植入在玻璃体视网膜疾病治疗中的应用[J]. 眼科新进展202040(7): 670-673.
[48]
苏鹏,孔祥斌,黄玉娟,等. 折叠式人工玻璃体球囊在外伤性硅油依赖眼中的临床应用[J]. 实用临床医学202021(7): 52-54.
[49]
Zhang B, Li C, Jia Y, et al. A pilot clinical study of treating rhegmatogenous retinal detachment by silicone rubber balloon scleral buckling[J]. Retina, 2020, 40(10): 1918-1928.
[50]
Haller J, Bandello F, Belfort R, et al. Randomized, Sham-Controlled Trial of Dexamethasone Intravitreal Implant in Patients with Macular Edema Due to Retinal Vein Occlusion[J]. Ophthalmology, 2010, 117(6): 1134-1146.
[51]
Pavesio C, Zierhut M, Bairi K, et al. Evaluation of an Intravitreal Fluocinolone Acetonide Implant versus Standard Systemic Therapy in Noninfectious Posterior Uveitis[J]. Ophthalmology, 2010, 117(3): 567-575.
[1] 李岩, 刘洋辰, 邓美玉, 王琦妙, 武斌, 高建民, 张楠, 刘冬, 刘学一. 光学与超声生物测量在观察玻璃体积血及视网膜脱离患眼视轴长度中的应用[J]. 中华医学超声杂志(电子版), 2017, 14(10): 738-742.
[2] 吴瑟菲, 苗金红, 谭舒眉, 李学民, 韩亮, 次仁琼达, 央珍, 胡晋平. 纯全氟丙烷填充联合玻璃体切割术治疗视网膜脱离的临床疗效观察[J]. 中华眼科医学杂志(电子版), 2023, 13(04): 205-209.
[3] 林明玥, 周祁, 刘歆, 曲申, 陈开传, 吕筱, 韩雯婷, 毕燕龙. 术中光学相干断层扫描辅助玻璃体Berger腔切除术的临床研究[J]. 中华眼科医学杂志(电子版), 2023, 13(04): 199-204.
[4] 张珂, 刘武. 近视眼牵引性黄斑病变相关因素的研究现状[J]. 中华眼科医学杂志(电子版), 2021, 11(06): 380-384.
[5] 曾百卉, 王倩, 韩宁, 隋桂琴. 下方孔源性视网膜脱离手术治疗的进展[J]. 中华眼科医学杂志(电子版), 2021, 11(01): 60-64.
[6] 贾力蕴, 张永鹏, 佘海澄, 周海英, 高丽琴, 马凯, 魏文斌. 儿童孔源性视网膜脱离发病特点、病因及手术方式的临床研究[J]. 中华眼科医学杂志(电子版), 2021, 11(01): 35-40.
[7] 李玲, 侯军军, 张红. 玻璃体切割联合内界膜剥除术对孔源性视网膜脱离疗效的Meta分析[J]. 中华眼科医学杂志(电子版), 2021, 11(01): 14-21.
[8] 李林, 韩崧, 王海燕, 杨光然, 佘海澄, 卢海. 外伤性视网膜脱离术后复发的临床特征分析[J]. 中华眼科医学杂志(电子版), 2020, 10(03): 153-159.
[9] 杨来庆, 张沧霞, 谢立科, 郝晓凤, 明静, 孙会兰, 李晓宇. 手术显微镜直视下巩膜外加压治疗孔源性视网膜脱离的临床观察[J]. 中华眼科医学杂志(电子版), 2018, 08(03): 116-121.
[10] 戴荣平, 尹心恺, 曲艺, 龙琴. 重视高度近视眼黄斑裂孔性视网膜脱离的手术治疗[J]. 中华眼科医学杂志(电子版), 2018, 08(03): 97-102.
[11] 叶彬, 王昌成, 韩成艳, 刘树青, 梁凤. 莫沙必利联合二甲硅油散在慢性便秘患者结肠镜检查肠道准备中的应用[J]. 中华消化病与影像杂志(电子版), 2019, 09(05): 203-207.
[12] 董海燕, 庞秋萍, 苏淑芬, 张燕, 卢艳, 贾欣永. 链酶蛋白酶联合二甲基硅油对胃镜检查清晰度的影响[J]. 中华消化病与影像杂志(电子版), 2019, 09(02): 65-67.
[13] 付鹏, 沈念, 黄艳玲, 杨水平, 万小波. 外伤性晶状体脱位合并周边隐匿性视网膜病变的临床特征及预后分析[J]. 中华临床医师杂志(电子版), 2022, 16(06): 536-540.
[14] 詹大方, 刘宏涛, 刘雁军, 张元川, 杨华武, 刘丽娅. 西甲硅油改善肥胖症患者腹腔镜下袖状胃切除术后胃肠道功能的研究[J]. 中华肥胖与代谢病电子杂志, 2019, 05(01): 10-14.
阅读次数
全文


摘要