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中华眼科医学杂志(电子版) ›› 2019, Vol. 09 ›› Issue (03) : 172 -176. doi: 10.3877/cma.j.issn.2095-2007.2019.03.008

综述

糖尿病视网膜病变与血清生化指标的相关性研究
姜姗1, 朱丹1,(), 陶勇2   
  1. 1. 010050 呼和浩特,内蒙古医科大学附属医院眼科
    2. 100020 首都医科大学附属北京朝阳医院眼科
  • 收稿日期:2019-03-16 出版日期:2019-06-28
  • 通信作者: 朱丹
  • 基金资助:
    国家自然科学基金项目(81860178,81560165); 国家高技术研究发展计划(2015AA020949); 北京朝阳医院"1351人才培养计划"(CYXX-2017-21)

The correlation between diabetic retinopathy and serum biochemical indexes

Shan Jiang1, Dan Zhu1,(), Yong Tao2   

  1. 1. Department of Ophthalmology, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China
    2. Department of Ophthalmology, Beijing Chaoyang Hospital Affiliated to Capital Medical University, Beijing 100020, China
  • Received:2019-03-16 Published:2019-06-28
  • Corresponding author: Dan Zhu
引用本文:

姜姗, 朱丹, 陶勇. 糖尿病视网膜病变与血清生化指标的相关性研究[J/OL]. 中华眼科医学杂志(电子版), 2019, 09(03): 172-176.

Shan Jiang, Dan Zhu, Yong Tao. The correlation between diabetic retinopathy and serum biochemical indexes[J/OL]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2019, 09(03): 172-176.

糖尿病视网膜病变(DR)是发生于糖尿病患者眼部的微血管病变,可致患者视力丧失,严重降低患者生存质量。DR的发病机制目前尚无定论,主要观点认为长期慢性高血糖是其发病基础,多种因素共同作用导致病情进展。目前,已证实眼内液炎症因子与DR存在关联,并在临床给予患者眼内注射药物治疗。鉴于眼内注射药物具有一定的缺点,且血清炎症因子对DR的发展也有影响,本文中笔者就血清中的生化指标与DR的关联性进行综述。

Diabetic retinopathy (DR) is a microangiopathy lesion which occurs in diabetic patients′ eyes. It can cause vision loss and seriously reduce patient′s life quality. The pathogenesis of DR is still uncertain. The main viewpoint is that long-term chronic hyperglycemia is the basis of the disease, and multiple factors may play a role in phases, contributing to the overall outcome of DR process. Inflammatory factors in intraocular fluid have been confirmed to be associated with DR, thus intraocular drug therapy is given in clinic. In view of shortcomings of intraocular injection drug and the influence of serum inflammatory factors on the development of DR, this paper summarizes the relationship between serum biochemical indices and DR.

图1 血管内皮生长因子引起糖尿病视网膜病变的机制示意图
图2 生长抑素对糖尿病视网膜病变的保护作用示意图
图3 氧化应激诱导糖尿病视网膜病变示意图
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