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中华眼科医学杂志(电子版) ›› 2019, Vol. 09 ›› Issue (02) : 124 -128. doi: 10.3877/cma.j.issn.2095-2007.2019.02.010

综述

角膜上皮功能障碍的研究进展
胡欢1, 韩玲玲2, 张明昌3,†()   
  1. 1. 438200　黄冈，湖北科技学院附属浠水医院眼科
    2. 438200　黄冈，湖北科技学院附属浠水医院妇产科
    3. 430000　武汉，华中科技大学同济医学院附属协和医院眼科
  • 收稿日期:2019-03-20 出版日期:2019-04-28
  • 通信作者: 张明昌
  • 基金资助:
    国家重点研发计划"政府间国际科技创新合作/港澳台科技创新合作"重点专项(2017YFE0103500)

Research progress in corneal epithelial dysfunction

Huan Hu1, Lingling Han2, Mingchang Zhang3,†()   

  1. 1. Department of Ophthalmology, Hubei University of Science and Technology Affiliated Xishui Hospital, Xishui 438200, Hubei Province, China
    2. Department of Gynaecology and Obstetrics, Hubei University of Science and Technology Affiliated Xishui Hospital, Xishui 438200, Hubei Province, China
    3. Department of Ophthalmology, Union Hospital Affiliated with Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430000, Hubei Province, China
  • Received:2019-03-20 Published:2019-04-28
  • Corresponding author: Mingchang Zhang
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胡欢, 韩玲玲, 张明昌. 角膜上皮功能障碍的研究进展[J]. 中华眼科医学杂志(电子版), 2019, 09(02): 124-128.

Huan Hu, Lingling Han, Mingchang Zhang. Research progress in corneal epithelial dysfunction[J]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2019, 09(02): 124-128.

角膜上皮功能障碍，即角膜缘干细胞功能未出现失代偿的条件下，角膜上皮细胞的细胞学行为及其功能异常。患眼呈现疼痛、眼红、畏光、流泪、异物感及睁眼困难等症状。其病因多源于外伤、干眼症、药物毒性、眼前段手术及神经营养性角膜上皮功能异常等病因导致。治疗方法主要有保守治疗和手术治疗。保守治疗方法包括人工泪液、自体血清和软性角膜接触镜；手术治疗方法包括羊膜移植、角膜前基质针刺术和准分子激光治疗性角膜切削术等。

关键词: 角膜上皮, 细胞连接, 眼外伤, 干眼症, 药物毒性, 眼前段手术

Corneal epithelial dysfunction was defined as corneal epithelial cell biological behaviors and functions abnormal without limbal stem cells dysfunction. The affected eyes represent symptoms such as eye pain, redness, photophobia, tearing, foreign body sensation and difficulty in blinking. Corneal epithelial dysfunction is mainly caused by trauma, dry eye, drug toxicity, anterior segment surgery and neurotrophic corneal epithelial dysfunction. The conservative and interventional treatments were two major treatments for corneal epithelial dysfunction. The conservative treatments for corneal epithelial dysfunction include artificial tears, autologous serum and soft gas permeable contact lens. Moreover, amniotic membrane transplantation, anterior stromal puncture and photorefractive therapeutic keratectomy are recognized as interventional treatments.

Key words: Corneal epithelial, Cell junction, Trauma, Dry eye, Drug toxicity, Anterior segment surgery
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