纹美瞳线与干眼症的相关性研究

doi:10.3877/cma.j.issn.2095-2007.2018.01.005

目的

探讨纹美瞳线与干眼症发病的关系。

方法

收集2013年9月至2016年12月于内蒙古医科大学附属医院眼科就诊的女性干眼症患者100例(200只眼)的临床资料。全部患者均纹刺过美瞳线，设为病例组。患者年龄为24～42岁，平均年龄为(28.5±8.3)岁；纹美瞳线的时间为2～8年，平均时间为(4.5±2.5)年。另选取未纹美瞳线及眼线的女性健康查体者100例(200只眼)，设为对照组，年龄为23～44岁，平均年龄为(29.1±7.8)岁。比较两组研究对象的眼表疾病指数(OSDI)评分、角膜荧光染色评分、泪膜破裂时间(BUT)及泪液分泌试验(SIT)结果。病例组和对照组的OSDI评分、角膜荧光染色评分、SIT结果及BUT采用均数±标准差(±s)表示，采用独立样本t检验进行组间均数比较。

结果

病例组患者的OSDI评分显示有轻度或中度的干眼症状，SIT结果倾向异常，BUT结果提示泪膜不稳定。病例组及对照组的OSDI评分分别为7.90±2.50及16.20±6.40，两组比较，差异有统计学意义(t＝10.80，P<0.05)。病例组及对照组的角膜荧光染色评分分别为2.88±0.73及1.34±0.52，两组比较，差异有统计学意义(t＝17.24，P<0.05)。病例组及对照组的SIT分别为(9.30±0.88)mm及(12.68±1.17)mm，两组比较，差异有统计学意义(t＝23.06，P<0.05)。病例组及对照组的BUT分别为(4.17±0.89)s及(11.02±0.16)s，两组比较，差异有统计学意义(t＝37.63，P<0.05)。

结论

纹美瞳线与干眼症的发生具有相关性。但纹美瞳线对于干眼症的病程及治疗的影响仍需进一步探讨。

关键词: 干眼症, 纹美瞳线, 相关性

Objective

Researching and observing the relationship of tattooing contact lenses and dry eye.

Methods

The clinical data of 100 female dry eye patients (200 eyes) were collected from September 2013 to December 2016 in the ophthalmology department of the Affiliated Hospital of Inner Mongolia Medical University. All the patients were set up as case group. The age of the patients were from 24 to 42 years, the age range were (28.5±8.3) years, and the time of the tattoo pupil was from 2 to 8 years, and the age range were (4.5±2.5) years. Another 100 female healthy subjects (200 eyes) were selected as control group. The age were from 23 to 44 years and the range age were (29.1±7.8) years. Compared the scores of these two groups ocular surface disease index (OSDI), fluorescein vital staining , tear break-up time (BUT) and lacrimal secretion test (SIT). The OSDI score, corneal fluorescein staining score, SIT result and BUT in case group and control group were all expressed by mean±standard deviation(±s). An independent sample t-test was used to compare the average number of groups.

Results

The OSDI score of the patients in the case group showed mild or moderate dry eye symptoms, and the SIT results tended to be abnormal, and the BUT results suggested that the tear film was unstable. The OSDI scores in the case group and the control group were (7.90±2.50) and (16.20±6.40) respectively. The difference between the two groups was statistically significant (t=10.8, P<0.05). The corneal fluorescent staining scores in the case group and the control group were (2.88±0.73) and (1.34±0.52) respectively. The difference between the two groups was statistically significant (t=17.24, P<0.05). The SIT in the case group and the control group were (9.30±0.88)mm and (12.68±1.17)mm respectively. The difference between the two groups was statistically significant (t=23.06, P<0.05). Pattern of cosmetic contact lenses and a control group of BUT group respectively (4.17±0.89)s, (11.02±0.16)s, the two groups, the difference was statistically significant (t=37.63, P<0.05).

Conclusion

There is a correlation between the striate eye pupil and the occurrence of dry eye. However, the influence of the tattoo pupil line on the course and treatment of dry eye should be further explored.

Key words: Dry eye, Tattooing contact lenses line, Relativity

表1 病例组和对照组各项眼表评分的描述和比较(±s)

组别	眼数	OSDI评分	角膜荧光染色评分	SIT(mm)	BUT(s)
对照组	200	16.20±6.40	1.34±0.52	12.68±1.17	11.02±0.16
病例组	200	7.90±2.50	2.88±0.73	9.30±0.88	4.17±0.89
t值	?	10.80	17.24	23.06	37.63
P值	?	<0.05	<0.05	<0.05	<0.05

表1 病例组和对照组各项眼表评分的描述和比较(±s)

组别	眼数	OSDI评分	角膜荧光染色评分	SIT(mm)	BUT(s)
对照组	200	16.20±6.40	1.34±0.52	12.68±1.17	11.02±0.16
病例组	200	7.90±2.50	2.88±0.73	9.30±0.88	4.17±0.89
t值	?	10.80	17.24	23.06	37.63
P值	?	<0.05	<0.05	<0.05	<0.05

[1]	叶芬，吴艳. 纹眼线对睑板腺功能的影响[J]. 临床眼科杂志，2017，25(3):262-264.
[2]	Werkmeister RM, Alex A, Kaya S, et al. Measurement of tear film thickness using ultrahigh－resolution optical coherence tomography[J]. Invest Ophthalmol Vis Sci, 2013, 54(8):5578-5583.
[3]	Kuçukaydin M, Ozokutan BH, Turan C, et al. Malformation of the epididymis in undescended testis[J]. Pediatric Surgery International, 1998, 14(3):189-191.
[4]	中华医学会眼科学分会角膜病学组. 干眼临床诊疗专家共识(2013年)[J]. 中华眼科杂志，2013, 49(1):73-75.
[5]	邢建男，赵海霞，隋瑶. 干眼综合征的治疗进展[J]. 山东医药，2016，56(39):110-112.
[6]	赵慧，刘祖国，杨文照，等. 我国干眼问卷的研制及评估[J]. 中华眼科杂志，2015，51(9):647-654.
[7]	Ban Y, Shimazaki－Den S, Tsubota K, et al. Morphological evaluation of meibomian glands using noncontact infrared meibography[J]. Ocular Surface, 2013, 11(1):47-53.
[8]	Finis D, Pischel N, Schrader S, et al. Evaluation of lipid layer thickness measurement of the tear film as a diagnostic tool for Meibomian gland dysfunction[J]. Cornea, 2013, 32(12):1549-1553.
[9]	Bitton E, Wittich W. Influence of eye position on the Schirmer tear test[J]. Contact Lens & Anterior Eye, 2014, 37(4):257-261.
[10]	Bron AJ, Smith JA, Calonge M. Methodologies to Diagnose and Monitor Dry Eye Disease: Report of the Diagnostic Methodology Subcommittee of the International Dry Eye WorkShop (2007)[J]. Ocular Surface, 2007, 5(2):108-152.
[11]	Nelson JD, Shimazaki J, Benitez－Del－Castillo JM, et al. The international workshop on meibomian gland dysfunction: report of the definition and classification subcommittee[J]. Invest Ophthalmol Vis Sci, 2011, 52(4):1930-1937.
[12]	Barabino S, Chen Y, Chauhan S, et al. Ocular surface immunity: Homeostatic mechanisms and their disruption in dry eye disease[J]. Progress in Retinal & Eye Research, 2012, 31(3):271-285.
[13]	Bron AJ, Tomlinson A, Foulks GN, et al. Rethinking Dry Eye Disease: A Perspective on Clinical Implications[J]. Ocular Surface, 2014, 12(2):1-31.
[14]	Hunter M, Bhola R, Yappert MC, et al. Pilot Study of the Influence of Eyeliner Cosmetics on the Molecular Structure of Human Meibum.[J]. Ophthalmic Research, 2015, 53(3):131-135.
[15]	Lemp MA. Advances in Understanding and Managing Dry Eye Disease[J]. Am J Ophthalmol, 2008, 146(3):350-356.
[16]	Yagci A, Gurdal C. The role and treatment of inflammation in dry eye disease[J]. Int Ophthalmol, 2014, 34(6):1291-1301.
[17]	龙潭，梁厚成，朱秀萍. 纹眼线对于干眼症发病的影响[J]. 国际眼科杂志，2010, 10(1):177-178.
[18]	Shao Y, Yu Y, Yu J, et al. Experimental study on efficiency of Spanishneedles Herb eye drops in treating perimenopausal xerophthalmia in rabbits[J]. China Journal of Chinese Materia Medica, 2015, 40(6):1151-1155.
[19]	Li Y, Bookman AM. Limited Scleroderma (Crest Syndrome) is Associated with Worse Xerostomia and Xerophthalmia in Patients Being Evaluated for Primary Sjogren′s Syndrome[J]. Annals of the Rheumatic Diseases, 2015, 74(Suppl. 2):583-584.
[20]	Chiu M, Dillon A, Watson S. Vitamin A deficiency and xerophthalmia in children of a developed country[J]. Journal of Paediatrics & Child Health, 2016, 52(7):699-703.
[21]	Kong X, Yan C, Ma W, et al. Sodium hyaluronate′s effect on xerophthalmia: a meta－analysis of randomized controlled trials[J]. Current Medical Research & Opinion, 2016, 32(3):477-484.
[22]	Hui G, Zhao XD, Guo－Juan MA, et al. Acupuncture combined with pyonex for xerophthalmia[J]. World Journal of Acupuncture－Moxibustion, 2016, 26(2):37-42.
[23]	Singh V, WK Jr. Vitamin A deficiency and xerophthalmia among school－aged children in Southeastern Asia[J]. European Journal of Clinical Nutrition, 2004, 58(10):1342-1349.
[24]	Naeini FF, Pourazizi M, Abtahi－Naeini B, et al. Looking beyond the cosmetic tattoo lesion near the eyebrow: Screening the lungs[J]. Journal of Postgraduate Medicine, 2017, 63(2):132-134.
[25]	Semba RD, De PS, Panagides D, et al. Risk factors for xerophthalmia among mothers and their children and for mother－child pairs with xerophthalmia in Cambodia[J]. Archives of Ophthalmology, 2004, 122(4):517-523.
[26]	Wang ZL, He HQ, Huang D, et al. Effect of integral syndrome differentiation acupuncture on the tear film stability in the patient of xerophthalmia[J]. Chinese Acupuncture & Moxibustion, 2005, 25(7):460-463.
[27]	Ma Y, Wang C, Liu M. Corneal epithelial cell apoptosis and related gene expression in castrated male rabbits with experimental xerophthalmia[J]. Chinese Ophthalmic Research, 2004, 22(3):286-289.
[28]	Baudouin C, Pisella PJ, Brignole F. Current treatments of xerophthalmia in Sjögren′s syndrome[J]. Revue De Medecine Interne, 2004, 25(5):376-382.
[29]	Khan AO. Xerophthalmia occurring after strabismus surgery[J]. Journal of American Association for Pediatric Ophthalmology & Strabismus, 2004, 8(2):192-193.
[30]	Gilbard JP, Farris RL, Nd SJ. Osmolarity of tear microvolumes in keratoconjunctivitis sicca[J]. Arch Ophthalmol, 1978, 96(4):677-681.
[31]	Dorado FM, Salasgarcía T, Lópezgómez A, et al. Granulomatous reaction in a patient with eyebrows tattoo[J]. Medicina Clínica (English Edition), 2016, 146(1):e5.
[32]	Liu ZY, Li CR. Teatment of dry eye caused by meibomianlang dysfunction[J]. Int Eye Sci, 2014, 14(2):270-272.
[33]	罗顺荣，邹留河，闫超，等. 自体唇腺移植治疗重症干眼[J]. 中华眼科杂志，2013, 49(1):22-26.
[34]	陈志远，王静，吴晓霞，等. 自体唇腺移植治疗重症角结膜干燥症[J]. 首都医科大学学报，2016，37(3):281-285.
[35]	Eveleth DD. Cell－Based Therapies for Ocular Disease[J]. Journal of Ocular Pharmacology & Therapeutics, 2013, 29(10):844-854.
[36]	Glenn JD, Whartenby KA. Mesenchymal stem cells: emergingmechanismsof immunomodulation and therapy[J]. World J Stem Cells, 2014, 6(5):526-539.
[37]	Klinker MW, Wei CH. Mesenchymal stem cells in the treatment of inflammatory and autoimmune diseases in experimental animal models[J]. World J Stem Cells, 2015, 7(3):556-567.
[38]	Weng J, He C, Lai P, et al. Mesenchymal Stromal Cells Treatment Attenuates Dry Eye in Patients With Chronic Graft－versus－host Disease[J]. Molecular Therapy, 2012, 20(12):2347-2354.
[39]	Xu J, Wang D, Liu D, et al. Allogeneic mesenchymal stem cell treatment alleviates experimental and clinical Sjögren syndrome[J]. Blood, 2012, 120(15):3142-3151.
[40]	周婉瑜，李越虹，寇秋爱. 滋阴润目汤治疗干眼症的临床观察[J]. 中国中医眼科杂志，2006, 16(4):202-204.
[41]	李点. 滋阴润燥法治疗干眼症临床观察[J]. 中国中医药信息杂志，2007, 14(3):48.
[42]	Chang YH, Lin HJ, Li WC. Clinical evaluation of the traditional chinese prescription Chi－Ju－Di－Huang－Wan for dry eye[J]. Phytotherapy Research Ptr, 2005, 19(4):349-354.
[43]	魏立新，杨威，王宏才，等. 针灸治疗干眼症40例临床观察[J]. 中国中医药信息杂志，2010, 17(5):65-66.
[44]	李影，高卫萍. 干眼症的中医药治疗近况[J]. 山东中医杂志，2010, 29(2):139-140.
[45]	Cerretani CF, Ho NH, Radke CJ. Water－evaporation reduction by duplex films: application to the human tear film[J]. Advances in Colloid & Interface Science, 2013, 197(11):33-57.
[46]	刘爽，唐少华. 眼睑刷区域的解剖及组织形态的共聚焦显微镜观察[J]. 中华眼视光学与视觉科学杂志，2014, 16(10):610-614.
[47]	Eom Y, Lee JS, Kang SY, et al. Correlation between quantitative measurements of tear film lipid layer thickness and meibomian gland loss in patients with obstructive meibomian gland dysfunction and normal controls[J]. Am J Ophthalmol, 2013, 155(6):1104-1110.
[48]	Sweeney DF, Millar TJ, Raju SR. Tear film stability: a review[J]. Experimental Eye Research, 2013, 117(12):28-38.
[49]	Pucker AD, Nichols JJ. Analysis of meibum and tear lipids[J]. Ocular Surface, 2012, 10(4):230-250.
[50]	Pucker AD, Nichols JJ. Impact of a rinse step on protein removal from silicone hydrogel contact lenses[J]. Optom Vis Sci, 2009, 86(8):943-947.
[51]	王玉倩，董诺，吴护平. 睑板腺形态学的研究进展[J]. 中华眼科杂志，2014, 50(4):299-302.
[52]	徐玉梅，李万明. 综合策略治疗睑板腺功能障碍性干眼症疗效分析[J]. 中国现代医药杂志，2015，17(11):28-31.
[53]	Bourra H, Hassam B. Contact dermatitis after black henna tattoo[J]. Medicina Clínica, 2013, 14(8):154.
[54]	孟宪实，李莹，刘小伟. 睑板腺功能障碍的研究进展[J/CD]. 中华眼科医学杂志：电子版，2016, 6(3):136-140.
[55]	Korb DR, Blackie CA. Debridement－scaling: a new procedure that increases Meibomian gland function and reduces dry eye symptoms[J]. Cornea, 2013, 32(12):1554-1557.
[56]	叶芬，吴艳，朱小敏，等. 纹眼线对睑板腺功能的影响[J]. 临床眼科杂志，2017, 25(3):262-264.
[57]	Turan H, Okur M, Kaya E, et al. Allergic contact dermatitis to para－phenylenediamine in a tattoo: a case report[J]. Journal of Toxicology Cutaneous & Ocular Toxicology, 2013, 32(2):185-187.
[58]	Brodie J, Galhud HE, Bates A. A case of episcleral tattooing－an emerging body modification trend[J]. BMC Ophthalmology, 2015, 15(1):95.
[59]	Koprowski R, Wilczynski S, Olczyk P, et al. A quantitative method for assessing the quality of meibomian glands[J]. Comput BiolMed, 2016, 75(2):130-138.
[60]	Nichols KK, Foulks GN, Bron AJ, et al. The international workshop on meibomian gland dysfunction: executive summary[J]. Invest Ophthalmol Vis Sci, 2011, 52(4):1922-1929.
[61]	Jacob J, Van Calster J. Skin tattoos and the development of uveitis[J]. Acta Ophthalmol, 2013, 91(8):650-652.
[62]	Mansour AM, Chan CC. Tattoo－associated uveitis[J]. Am J Ophthalmol, 2014, 158(3):637-643.
[63]	Sherif S, Blakeway E, Fenn C, et al. A Case of squamous cell carcinoma developing with win a red－ink tattoo[J]. Journal of Cutaneous Medicine & Surgery, 2017, 21(1):61-63
[64]	蒋红旗. 睑板腺功能障碍所致干眼症的治疗[J]. 医药前沿，2016, 6(15):205-207.

[1]	张巧梅, 孙小平, 李冠胜, 邓扬嘉. 针灸对大鼠呼吸机相关性肺炎中性粒细胞归巢及胞外诱捕网的影响[J]. 中华危重症医学杂志(电子版), 2023, 16(04): 265-271.
[2]	张晓燕, 肖东琼, 高沪, 陈琳, 唐发娟, 李熙鸿. 转录因子12过表达对脓毒症相关性脑病大鼠大脑皮质的保护作用及其机制[J]. 中华妇幼临床医学杂志(电子版), 2023, 19(05): 540-549.
[3]	魏徐, 张鸽, 伍金林. 新生儿脓毒症相关性凝血病的监测和治疗[J]. 中华妇幼临床医学杂志(电子版), 2023, 19(04): 379-386.
[4]	崔占斌, 乔军利, 张丽丽, 韩明强. 尿碘水平与甲状腺乳头状癌患者术后复发危险度分层的相关性[J]. 中华普外科手术学杂志(电子版), 2023, 17(06): 615-618.
[5]	高静, 严学倩, 及月茹, 郝淼旺, 刘苍春. 胃癌患者以慢性贫血为首发表现的高危因素Logistic分析[J]. 中华普外科手术学杂志(电子版), 2023, 17(05): 534-537.
[6]	李晓晖, 上官昌盛, 向英, 裴芝皆, 车俊志, 谢飞. 3D腹腔镜袖状胃切除术后机体能量代谢与多囊卵巢综合征患者性激素水平关系[J]. 中华普外科手术学杂志(电子版), 2023, 17(05): 538-541.
[7]	安钱, 徐彬, 陈志祥, 徐晶晶, 黄丹丹. PCT、CRP及SAA对呼吸机相关性肺炎病情严重程度和预后分析[J]. 中华肺部疾病杂志(电子版), 2023, 16(04): 544-546.
[8]	潘春江, 李科, 李新楼, 杨博, 任雪玲. 高龄老人骨转换代谢标志物与肾功能的相关性研究[J]. 中华肾病研究电子杂志, 2023, 12(05): 260-264.
[9]	张瑞琪, 张丽娟, 孙斌. 甲状腺相关性眼病表观遗传学的研究进展[J]. 中华眼科医学杂志(电子版), 2023, 13(04): 226-230.
[10]	尤素伟. 老年脑卒中后吞咽障碍与卒中相关性肺炎的相关性研究[J]. 中华脑科疾病与康复杂志(电子版), 2023, 13(03): 150-155.
[11]	张郁妍, 胡滨, 张伟红, 徐楣, 朱慧, 羊馨玥, 刘海玲. 妊娠中期心血管超声参数与肝功能的相关性及对不良妊娠结局的预测价值[J]. 中华消化病与影像杂志(电子版), 2023, 13(06): 499-504.
[12]	魏红涛, 普布仓决, 格桑央宗, 黎燕, 益西旺扎, 李鹏. 拉萨地区上消化道溃疡患者幽门螺杆菌感染及治疗分析[J]. 中华临床医师杂志(电子版), 2023, 17(06): 662-665.
[13]	陈捷, 白易, 刘金波, 刘欢, 赵娜, 赵红薇, 王宏宇. 中老年人群中性粒细胞和高密度脂蛋白比值与下肢动脉疾病的相关性[J]. 中华临床医师杂志(电子版), 2023, 17(04): 402-408.
[14]	王昊, 明倩文, 王斌, 卢太坤, 张海宁. 利奈唑胺致黑毛舌的临床诊断学特征[J]. 中华诊断学电子杂志, 2023, 11(04): 254-260.
[15]	王燕, 郭蕊, 王淑杰. 老年烧伤气管切开患者死亡风险诊断模型构建及对策分析[J]. 中华诊断学电子杂志, 2023, 11(04): 249-253.

阅读次数

全文

摘要

选择文件类型/文献管理软件名称

选择包含的内容

A study of the correlation between the tattooing contact lenses line and the dry eye

模态框（Modal）标题

选择文件类型/文献管理软件名称

选择包含的内容

A study of the correlation between the tattooing contact lenses line and the dry eye