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中华眼科医学杂志(电子版) ›› 2017, Vol. 07 ›› Issue (06) : 279 -283. doi: 10.3877/cma.j.issn.2095-2007.2017.06.008

所属专题: 文献

综述

嗜人T淋巴细胞病毒Ⅰ型感染所致葡萄膜炎基础研究的新进展
汪晓娟1, 朱丹1,(), 陶勇2   
  1. 1. 010050 呼和浩特,内蒙古医科大学附属医院眼科
    2. 100020 首都医科大学附属北京朝阳医院眼科
  • 收稿日期:2017-10-09 出版日期:2017-12-28
  • 通信作者: 朱丹
  • 基金资助:
    国家高技术研究发展计划项目(863计划)(2015AA020949); 霍英东教育基金会第十四届高等院校青年教师基金(141038)

New progress in basic research of uveitis caused by human T lymphocyte leukemia virus type Ⅰ infection

Xiaojuan Wang1, Dan Zhu1,(), Yong Tao2   

  1. 1. Department of Ophthalmology, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China
    2. Department of Ophthalmology, Beijing Chaoyang hospital affiliated to Capital Medical University, Beijing 100020, China
  • Received:2017-10-09 Published:2017-12-28
  • Corresponding author: Dan Zhu
  • About author:
    Corresponding author: Zhu Dan, Email:
引用本文:

汪晓娟, 朱丹, 陶勇. 嗜人T淋巴细胞病毒Ⅰ型感染所致葡萄膜炎基础研究的新进展[J]. 中华眼科医学杂志(电子版), 2017, 07(06): 279-283.

Xiaojuan Wang, Dan Zhu, Yong Tao. New progress in basic research of uveitis caused by human T lymphocyte leukemia virus type Ⅰ infection[J]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2017, 07(06): 279-283.

嗜人T淋巴细胞病毒(HTLV)是一种逆转录病毒,目前发现有3种亚型,即HTLV-Ⅰ、HTLV-Ⅱ及HTLV-Ⅲ。HTLV-Ⅰ与成人T细胞白血病(ATL)、HTLV-Ⅰ相关性脊髓病(HAM)及葡萄膜炎有关。HTLV-Ⅰ感染后不仅能够引发葡萄膜炎,同时也可能引起多种其他眼部疾病。目前,国内外大多数学者认为,HTLV-Ⅰ感染所致的葡萄膜炎(HAU)是由于HTLV-Ⅰ感染体内的T淋巴细胞,导致被感染的细胞因子聚集在眼内,从而引起的眼部炎症反应。本文中笔者对HAU的发病机制、临床特征、诊断方法、治疗手段及与其他疾病之间的关系进行综述。

Human T lymphotropic virus (HTLV) is a retrovirus that currently has 3 subtypes, namely HTLV-Ⅰ and HTLV-Ⅱ and HTLV-Ⅲ, HTLV-Ⅰ and adult T cell leukemia(ATL), HTLV-Ⅰ associated myelopathy(HAM) and uveitis on. HTLV-Ⅰ infection can not only cause uveitis, but also may cause a variety of other ocular symptoms. At present, most scholars believe that HTLV-Ⅰ infection induced uveitis (HAU) is due to the infection of HTLV-Ⅰ T lymphocytes in vivo, leading to cytokine infection gathered in the eye, causing inflammation of the eye. In this paper, the pathogenesis, clinical features, diagnostic methods, treatment methods and the relationship between HAU and other diseases are reviewed.

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