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中华眼科医学杂志(电子版) ›› 2018, Vol. 08 ›› Issue (04) : 175 -180. doi: 10.3877/cma.j.issn.2095-2007.2018.04.006

所属专题： 文献；

综述

人类白细胞抗原分型检测及其与眼部疾病相关性的研究进展
刘铭1, 何引章2, 陶勇2,†()   
  1. 1. 101399　北京智德臻和医学检验所
    2. 100020　首都医科大学附属北京朝阳医院眼科
  • 收稿日期:2018-05-06 出版日期:2018-08-28
  • 通信作者: 陶勇
  • 基金资助:
    国家高技术研究发展计划项目（863计划）(2015AA020949); 北京朝阳医院"1351人才培养计划"项目(CYXX－2017－21)

Research progress of both Human leukocyte antigen typing detections and the correlation between Human leukocyte antigen and ocular diseases

Ming Liu1, Yinzhang He2, Yong Tao2,†()   

  1. 1. Beijing Zhi De Genecast Medical Inspection Institute, Beijing 101399, China
    2. Department of Ophthalmology, Beijing Chaoyang hospital affiliated to Capital Medical University, Beijing 100020 , China
  • Received:2018-05-06 Published:2018-08-28
  • Corresponding author: Yong Tao
  • About author:
    Corresponding author: Tao Yong, Email:
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引用本文：

刘铭, 何引章, 陶勇. 人类白细胞抗原分型检测及其与眼部疾病相关性的研究进展[J]. 中华眼科医学杂志(电子版), 2018, 08(04): 175-180.

Ming Liu, Yinzhang He, Yong Tao. Research progress of both Human leukocyte antigen typing detections and the correlation between Human leukocyte antigen and ocular diseases[J]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2018, 08(04): 175-180.

人类白细胞抗原(HLA)，又称人类主要组织相容性复合体。其分型检测方法历经了血清学分型、细胞学分型及脱氧核糖核酸(DNA)分型的发展过程。目前，DNA分型检测方法为主要的HLA分型检测方法，且有逐渐取代其他两种分型检测方法的趋势。此外，经国内外的诸多学者研究发现，HLA与多种疾病具有相关性。其中，关于眼部疾病与HLA相关性的报道更是层出不穷，尤其是在葡萄膜炎的相关研究中。故本文拟对HLA分型检测及其与眼部疾病的相关性进行综述。

关键词: 人类白细胞抗原, 葡萄膜炎, 白塞病, 小柳原田综合征

Human leukocyte antigen (HLA), also known as human major histocompatibility complex. Its classification method has gone through the development of serological typing, cell classification and DNA typing. At present, the DNA typing method is the main HLA typing method, and it has gradually replaced the trend of the other two types of typing detection methods. In addition, many scholars at home and abroad have found that HLA is associated with a variety of diseases. Among them, reports on the correlation between eye diseases and HLA are emerging one after another, especially in the study of uveitis. Therefore, this article intends to review the correlation between HLA typing and ocular diseases.

Key words: Human leukocyte antigen, Uveitis, Behcet's disease, Vogt-Koyanagi-Harada syndrome
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