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中华眼科医学杂志(电子版) ›› 2022, Vol. 12 ›› Issue (05) : 305 -309. doi: 10.3877/cma.j.issn.2095-2007.2022.05.009

综述

肠道菌群与眼部常见疾病关系的研究进展
程英1, 安文在2, 林丹婷3, 王宁利1,()   
  1. 1. 100730 首都医科大学附属北京同仁医院 北京同仁眼科中心 北京市眼科研究所 北京眼科学与视觉科学重点实验室
    2. 100730 首都医科大学附属北京同仁医院2021级博士研究生
    3. 100730 首都医科大学附属北京同仁医院2019级博士研究生
  • 收稿日期:2021-10-24 出版日期:2022-10-28
  • 通信作者: 王宁利
  • 基金资助:
    北京市博士后工作经费资助项目(2021)

Advances in the relationship between gut microbiota and common ocular diseases

Ying Cheng1, Wenzai An2, Danting Lin3, Ningli Wang1,()   

  1. 1. Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Science, Bejing 100730, China
    2. Doctoral degree 2021, Beijing Tongren Hospital, Capital Medical University, Bejing 100730, China
    3. Doctoral degree 2019, Beijing Tongren Hospital, Capital Medical University, Bejing 100730, China
  • Received:2021-10-24 Published:2022-10-28
  • Corresponding author: Ningli Wang
引用本文:

程英, 安文在, 林丹婷, 王宁利. 肠道菌群与眼部常见疾病关系的研究进展[J/OL]. 中华眼科医学杂志(电子版), 2022, 12(05): 305-309.

Ying Cheng, Wenzai An, Danting Lin, Ningli Wang. Advances in the relationship between gut microbiota and common ocular diseases[J/OL]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2022, 12(05): 305-309.

肠道菌群是寄居在人体肠道内微生物群落的总称,它在机体消化、代谢及免疫调节等方面均发挥着重要作用。近年来,肠道菌群在参与不同疾病发生与发展的病理机制研究中已成为医学与微生物领域的热点之一,现已明确肠道菌群与多种眼病的发病机制有关。肠-眼轴假说认为肠道菌群失调可诱发局部及外周免疫反应,参与眼部疾病进展。本文中笔者从干眼、青光眼、葡萄膜炎、年龄相关性黄斑变性及糖尿病性视网膜病变等眼部常见疾病角度阐述肠道菌群与不同眼病的关系,旨在为眼部疾病的发病机制和治疗策略提供新思路。

Gut microbiota refers to the collection of microbial communities living in the human intestinal tract, which plays important roles in digestion, metabolism and immune regulation. In recent years, the study on the pathological mechanism of gut microbiota participating in the occurrence and progression of different diseases has become one of the most extended concerned hotspots worldwide nowadays, and the correlation between gut microbiota and the pathogenesis of various eye diseases has been demonstrated. The concept of the gut-eye axis indicates that the gut microbiota has a capacity of affecting the local and peripheral immune responses and participating in the pathological injuries of multiple eye diseases. The latest research progress on the relationship between gut microbiota and different eye diseases including dry eye, glaucoma, uveitis, age-related macular degeneration, and diabetic retinopathy has been syste-matically reviewed in this paper, which to provide new insights into the underlying mechanism and original treatment approaches of common ocular diseases.

图1 肠道菌群常用检测技术
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