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中华眼科医学杂志(电子版) ›› 2022, Vol. 12 ›› Issue (05) : 305 -309. doi: 10.3877/cma.j.issn.2095-2007.2022.05.009

综述

肠道菌群与眼部常见疾病关系的研究进展
程英1, 安文在2, 林丹婷3, 王宁利1,()   
  1. 1. 100730 首都医科大学附属北京同仁医院 北京同仁眼科中心 北京市眼科研究所 北京眼科学与视觉科学重点实验室
    2. 100730 首都医科大学附属北京同仁医院2021级博士研究生
    3. 100730 首都医科大学附属北京同仁医院2019级博士研究生
  • 收稿日期:2021-10-24 出版日期:2022-10-28
  • 通信作者: 王宁利
  • 基金资助:
    北京市博士后工作经费资助项目(2021)

Advances in the relationship between gut microbiota and common ocular diseases

Ying Cheng1, Wenzai An2, Danting Lin3, Ningli Wang1,()   

  1. 1. Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Science, Bejing 100730, China
    2. Doctoral degree 2021, Beijing Tongren Hospital, Capital Medical University, Bejing 100730, China
    3. Doctoral degree 2019, Beijing Tongren Hospital, Capital Medical University, Bejing 100730, China
  • Received:2021-10-24 Published:2022-10-28
  • Corresponding author: Ningli Wang
引用本文:

程英, 安文在, 林丹婷, 王宁利. 肠道菌群与眼部常见疾病关系的研究进展[J]. 中华眼科医学杂志(电子版), 2022, 12(05): 305-309.

Ying Cheng, Wenzai An, Danting Lin, Ningli Wang. Advances in the relationship between gut microbiota and common ocular diseases[J]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2022, 12(05): 305-309.

肠道菌群是寄居在人体肠道内微生物群落的总称,它在机体消化、代谢及免疫调节等方面均发挥着重要作用。近年来,肠道菌群在参与不同疾病发生与发展的病理机制研究中已成为医学与微生物领域的热点之一,现已明确肠道菌群与多种眼病的发病机制有关。肠-眼轴假说认为肠道菌群失调可诱发局部及外周免疫反应,参与眼部疾病进展。本文中笔者从干眼、青光眼、葡萄膜炎、年龄相关性黄斑变性及糖尿病性视网膜病变等眼部常见疾病角度阐述肠道菌群与不同眼病的关系,旨在为眼部疾病的发病机制和治疗策略提供新思路。

Gut microbiota refers to the collection of microbial communities living in the human intestinal tract, which plays important roles in digestion, metabolism and immune regulation. In recent years, the study on the pathological mechanism of gut microbiota participating in the occurrence and progression of different diseases has become one of the most extended concerned hotspots worldwide nowadays, and the correlation between gut microbiota and the pathogenesis of various eye diseases has been demonstrated. The concept of the gut-eye axis indicates that the gut microbiota has a capacity of affecting the local and peripheral immune responses and participating in the pathological injuries of multiple eye diseases. The latest research progress on the relationship between gut microbiota and different eye diseases including dry eye, glaucoma, uveitis, age-related macular degeneration, and diabetic retinopathy has been syste-matically reviewed in this paper, which to provide new insights into the underlying mechanism and original treatment approaches of common ocular diseases.

图1 肠道菌群常用检测技术
[1]
Zheng W, Zhao S, Yin Y, et al. High-throughput, single-microbe genomics with strain resolution, applied to a human gut microbiome [J]. Science, 2022, 376(6597): 1483.
[2]
Vujkovic-Cvijin I, Sklar J, Jiang L, et al. Host variables confound gut microbiota studies of human disease [J]. Nature, 2020, 587(7834): 448-454.
[3]
Shulman ST, Friedmann HC, Sims RH. Theodor escherich: The first pediatric infectious diseases physician? [J]. Clin Infect Dis, 2007, 45(8): 1025-1029.
[4]
周晶晶,王志,付欣,等. 肠道菌群在疾病中的研究进展 [J]. 延安大学学报(医学科学版)202018(2):93-96.
[5]
Fung TC, Olson CA, Hsiao EY. Interactions between the microbiota, immune and nervous systems in health and disease [J]. Nat Neurosci, 2017, 20(2): 145-155.
[6]
Rinninella E, Raoul P, Cintoni M, et al. What is the healthy gut microbiota composition? A changing ecosystem across age, environment, diet, and diseases [J]. Microorganisms, 2019, 7(1): e14.
[7]
Zmora N, Suez J, Elinav E. You are what you eat: Diet, health and the gut microbiota [J]. Nat Rev Gastroenterol Hepatol, 2019, 16(1): 35-56.
[8]
Fung TC, Olson CA, Hsiao EY. Interactions between the microbiota, immune and nervous systems in health and disease [J]. Nat Neur, 2017, 20(2): 145-155.
[9]
Pane M, Amoruso A, Deidda F, et al. Gut microbiota, probiotics, and sport: From clinical evidence to agonistic performance [J]. J Clin Gastroenterol, 2018, 52(S1): s46-s49.
[10]
Doyle SL, Campbell M, Ozaki E, et al. Nlrp3 has a protective role in age-related macular degeneration through the induction of il-18 by drusen components [J]. Nat Med, 2012, 18(5): 791-798.
[11]
Richards JL, Yap YA, Mcleod KH, et al. Dietary metabolites and the gut microbiota: An alternative approach to control inflammatory and autoimmune diseases [J]. Clin Transl Immunol, 2016, 5(5): e82.
[12]
Verhaar BJH, Prodan A, Nieuwdorp M, et al. Gut microbiota in hypertension and atherosclerosis: A review [J]. Nutrients, 2020, 12(10): e2982.
[13]
Niu SY, Yang J, Mcdermaid A, et al. Bioinformatics tools for quantitative and functional metagenome and metatranscriptome data analysis in microbes [J]. Brief Bioinform, 2018, 19(6): 1415-1429.
[14]
Langille M, Zaneveld J, Caporaso J, et al. Predictive functional profiling of microbial communities using 16srRNA marker gene sequences [J]. Nat Biotechnol, 2013, 31(9): 814-821.
[15]
Zhao L. The gut microbiota and obesity: From correlation to causality [J]. Nat Rev Microbiol, 2013, 11(9): 639-647.
[16]
Psianou K, Panagoulias I, Papanastasiou AD, et al. Clinical and immunological parameters of Sjögren′s syndrome [J]. Autoimmun Rev, 2018, 17(10): 1053-1064.
[17]
Moon J, Yoon CH, Choi SH, et al. Can gut microbiota affect dry eye syndrome? [J]. Int J Mol Sci, 2020, 21(22): e8443.
[18]
Fujimura KE, Sitarik AR, Havstad S, et al. Neonatal gut microbiota associates with childhood multisensitized atopy and T cell differentiation [J]. Nat Med, 2016, 22(10): 1187-1191.
[19]
De-Paiva CS, Jones DB, Stern ME, et al. Altered mucosal microbiome diversity and disease severity in Sjögren syndrome [J]. Sci Rep, 2016, 6: e23561.
[20]
Cano-Ortiz A, Laborda-Illanes A, Plaza-Andrades I, et al. Connection between the gut microbiome, systemic inflammation, gut permeability and foxp3 expression in patients with primary Sjögren′s syndrome [J]. Int J Mol Sci, 2020, 21(22): e8733.
[21]
Mandl T, Marsal J, Olsson P, et al. Severe intestinal dysbiosis is prevalent in primary Sjögren′s syndrome and is associated with systemic disease activity [J]. Arthritis Res Ther, 2017, 19(1): e237.
[22]
Van-der-Meulen TA, Harmsen HJM, Vila AV, et al. Shared gut, but distinct oral microbiota composition in primary Sjögren′s syndrome and systemic lupus erythematosus [J]. J Autoimmun, 2019, 97: 77-87.
[23]
Watane A, Cavuoto KM, Rojas M, et al. Fecal microbial transplant in individuals with immune-mediated dry eye [J]. Am J Ophthalmol, 2021, 233: 90-100.
[24]
Yun SW, Son YH, Lee DY, et al. Lactobacillus plantarum and bifidobacterium bifidum alleviate dry eye in mice with exorbital lacrimal gland excision by modulating gut inflammation and microbiota [J]. Food Funct, 2021, 12(6): 2489-2497.
[25]
Bron AJ, De-Paiva CS, Chauhan SK, et al. TFOS DEWS Ⅱ pathophysiology report [J]. Ocul Surf, 2017, 15(3): 438-510.
[26]
Schaefer L, Hernandez H, Coats RA, et al. Gut-derived butyrate suppresses ocular surface inflammation [J]. Sci Rep, 2022, 12(1): 4512.
[27]
Yoon CH, Ryu JS, Moon J, et al. Association between aging-dependent gut microbiome dysbiosis and dry eye severity in C57BL/6 male mouse model: A pilot study [J]. BMC Microbiol, 2021, 21(1): 106.
[28]
Tellefsen NS, Badian RA, Utheim TP, et al. Sex and age differences in symptoms and signs of dry eye disease in a norwegian cohort of patients [J]. Ocul Surf, 2021, 19: 68-73.
[29]
He M, Foster PJ, Ge J, et al. Prevalence and clinical characteristics of glaucoma in adult chinese: A population-based study in liwan district, guangzhou [J]. Invest Ophthalmol Vis Sci, 2006, 47(7): 2782-2788.
[30]
Gong H, Zhang S, Li Q, et al. Gut microbiota compositional profile and serum metabolic phenotype in patients with primary open-angle glaucoma [J]. Exp Eye Res, 2020, 191: e107921.
[31]
Gong H, Zeng R, Li Q, et al. The profile of gut microbiota and central carbon-related metabolites in primary angle-closure glaucoma patients [J]. Int Ophthalmol, 2022, 42(6): 1927-1938.
[32]
Mcpherson ZE, Srensen HT, Horváth-Puhó E, et al. Irritable bowel syndrome and risk of glaucoma: An analysis of two independent population-based cohort studies [J]. United European Gastroenterol J, 2021, 9(9): 1057-1065.
[33]
Tang J, Tang Y, Yi I, et al. The role of commensal microflora-induced T cell responses in glaucoma neurodegeneration [J]. Prog Brain Res, 2020, 256(1): 79-97.
[34]
Chen H, Cho KS, Vu THK, et al. Commensal microflora-induced T cell responses mediate progressive neurodegeneration in glaucoma [J]. Nat Commun, 2018, 9(1): 3209.
[35]
Xu H, Liu M, Cao J, et al. The dynamic interplay between the gut microbiota and autoimmune diseases [J]. J Immunol Res, 2019: 7546047.
[36]
Round JL, Mazmanian SK. Inducible foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota [J]. PNAS USA, 2010, 107(27): 12204-12209.
[37]
Horai R, Caspi RR. Microbiome and autoimmune uveitis [J]. Front Immunol, 2019, 10: e232.
[38]
Asquith MJ, Stauffer P, Davin S, et al. Perturbed mucosal immunity and dysbiosis accompany clinical disease in a rat model of spondyloarthritis [J]. Arthritis Rheumatol, 2016, 68(9): 2151-2162.
[39]
Ye Z, Wu C, Zhang N, et al. Altered gut microbiome composition in patients with Vogt-Koyanagi-Harada disease [J]. Gut microbes, 2020, 11(3): 539-555.
[40]
Ye Z, Zhang N, Wu C, et al. A metagenomic study of the gut microbiome in Behcet′s disease [J]. Microbiome, 2018, 6(1): e135.
[41]
Zinkernagel MS, Zysset-Burri DC, Keller I, et al. Association of the intestinal microbiome with the development of neovascular age-related macular degeneration [J]. Sci Rep, 2017, 7: 40826.
[42]
Lin P. Importance of the intestinal microbiota in ocular inflammatory diseases: A review [J]. Clin Exp Ophthalmol, 2019, 47(3): 418-422.
[43]
Napolitano P, Filippelli M, Davinelli S, et al. Influence of gut microbiota on eye diseases: An overview [J]. Ann Med, 2021, 53(1): 750-761.
[44]
Mosher KI, Wyss-Coray T. Go with your gut: Microbiota meet microglia [J]. Nat Neurosci, 2015, 18(7): 930-931.
[45]
Andriessen EM, Wilson AM, Mawambo G, et al. Gut microbiota influences pathological angiogenesis in obesity-driven choroidal neovascularization [J]. EMBO Mol Med, 2016, 8(12): 1366-1379.
[46]
Gorusupudi A, Nelson K, Bernstein PS. The age-related eye disease 2 study: Micronutrients in the treatment of macular degeneration [J]. Adv Nutr, 2017, 8(1): 40-53.
[47]
Lin P. The role of the intestinal microbiome in ocular inflammatory disease [J]. Curr Opin Ophthalmol, 2018, 29(3): 261-266.
[48]
Huang Y, Wang Z, Ma H, et al. Dysbiosis and implication of the gut microbiota in diabetic retinopathy [J]. Front Cell Infect Microbiol, 2021, 11: 646348.
[49]
Ye P, Zhang X, Xu Y, et al. Alterations of the gut microbiome and metabolome in patients with proliferative diabetic retinopathy [J]. Front Microbiol, 2021, 12: 667632.
[50]
Beli E, Yan Y, Moldovan L, et al. Restructuring of the gut microbiome by intermittent fasting prevents retinopathy and prolongs survival in db/db mice [J]. Diabetes, 2018, 67(9): 1867-1879.
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