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中华眼科医学杂志(电子版) ›› 2022, Vol. 12 ›› Issue (01) : 42 -46. doi: 10.3877/cma.j.issn.2095-2007.2022.01.008

综述

肿瘤坏死因子ɑ抑制剂在白塞病葡萄膜炎中的应用进展
贾辉钰1, 卢弘2,()   
  1. 1. 730000 兰州大学第一临床医学院2018级硕士研究生
    2. 730000 兰州大学第一临床医学院眼科;100020 首都医科大学附属北京朝阳医院眼科
  • 收稿日期:2022-01-10 出版日期:2022-02-28
  • 通信作者: 卢弘
  • 基金资助:
    甘肃省自然科学基金资助项目(17JR5RA225)

Progress in the application of tumor necrosis factor ɑ inhibitors in Behcet′s disease uveitis

Huiyu Jia1, Hong Lu2,()   

  1. 1. Master′s degree 2018, the First Clinical Medical College of Lanzhou University, Lanzhou 730000, China
    2. Department of Ophthalmology, First Clinical Medical College of Lanzhou University, Lanzhou 730000, China; Department of Ophthalmology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China
  • Received:2022-01-10 Published:2022-02-28
  • Corresponding author: Hong Lu
引用本文:

贾辉钰, 卢弘. 肿瘤坏死因子ɑ抑制剂在白塞病葡萄膜炎中的应用进展[J/OL]. 中华眼科医学杂志(电子版), 2022, 12(01): 42-46.

Huiyu Jia, Hong Lu. Progress in the application of tumor necrosis factor ɑ inhibitors in Behcet′s disease uveitis[J/OL]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2022, 12(01): 42-46.

白塞病(BD)是一种慢性自身免疫性炎症性疾病,BD累及眼部可引起严重的并发症。白塞病葡萄膜炎(BU)以非肉芽肿性炎症反复发作和消退为特征,其预后差,致盲率高。传统的治疗方法是激素联合免疫抑制剂。但对于病情严重,反复复发的长期治疗者会出现全身不良反应及潜在的感染,从而导致不可逆的视力丧失。近年来,肿瘤坏死因子(TNF)抑制剂的应用使葡萄膜炎的复发率和并发症得到明显控制。本文就TNF-α抑制剂治疗BU的研究现状进行综述,为难治性BU的治疗提供新的思路。

Behcet′s disease (BD) is a chronic autoimmune inflammatory disease. When BD has been involved in the eye, BD could cause serious complications. Behcet uveitis (BU) is characterized by recurrent episodes and regression of non-granulomatous inflammation, which has poor prognosis and a high rate of blindness. The traditional treatment for BU is to use hormone combined immunosuppressant. However, systemic adverse reactions and potential infections could occur for severe and long-term treatment patients, resulting in irreversible vision loss. In recent years, it has been demonstrated that the use of tumor necrosis factor (TNF) inhibitors could be helpful to significantly control the recurrence rate and complications of BU. The research status of TNF-ɑ inhibitors in the treatment of BU is reviewed, which could provide a new strategy for refractory BU.

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