切换至 "中华医学电子期刊资源库"

中华眼科医学杂志(电子版) ›› 2025, Vol. 15 ›› Issue (05) : 299 -303. doi: 10.3877/cma.j.issn.2095-2007.2025.05.008

综述

湿房镜的临床研究进展
武祎菲, 冯珺, 田磊, 接英()   
  1. 100730 首都医科大学附属北京同仁医院 北京同仁眼科中心 北京市眼科研究所 北京市眼科学与视觉科学重点实验室
  • 收稿日期:2025-08-22 出版日期:2025-10-28
  • 通信作者: 接英
  • 基金资助:
    北京市登峰人才计划项目(DFL20240202)

Clinical research progress of moisture chamber spectacles

Yifei Wu, Jun Feng, Lei Tian, Ying Jie()   

  1. Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Lab, Beijing 100730, China
  • Received:2025-08-22 Published:2025-10-28
  • Corresponding author: Ying Jie
引用本文:

武祎菲, 冯珺, 田磊, 接英. 湿房镜的临床研究进展[J/OL]. 中华眼科医学杂志(电子版), 2025, 15(05): 299-303.

Yifei Wu, Jun Feng, Lei Tian, Ying Jie. Clinical research progress of moisture chamber spectacles[J/OL]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2025, 15(05): 299-303.

近年来,干眼的发病率不断攀升,严重影响患者的生活质量。湿房镜作为一种有数十年发展史的非侵入性物理治疗手段,自20世纪70年代被引入干眼等眼表疾病的治疗以来,经历了从早期简易湿房结构到功能化产品的多代更新。湿房镜的核心机制在于通过在眼周形成相对封闭的湿润环境,减少泪液蒸发,保护眼表,并在干眼、暴露性角膜炎及术后眼表保护等多个领域治疗效果显著;同时,现已被国际与国内临床指南及专家共识纳入干眼的基础或辅助治疗方案。

In recent years, the incidence of dry eye disease has continued to increase, significantly, impairing patients′ quality of life. Moisture chamber spectacles (MCS), a non-invasive physical therapy with a development history spanning several decades, have been introduced into the management of dry eye and other ocular surface diseases since the 1970s, and have undergone multiple generations of evolution from early simple moisture chamber structures to functionally optimized products. The core mechanism of MCS lies in creating a relatively enclosed and humid periocular environment, thereby reducing tear evaporation and protecting the ocular surface. As a result, MCS have attracted increasing attention in the management of dry eye disease, exposure keratitis, and postoperative ocular surface protection, and have been concurrently incorporated into several international and national guidelines and expert consensuses as a basic or additional therapeutic option for dry eye disease.

表1 非加热型湿房镜临床应用的文献汇总表
第一作者 国籍 发表年份(年) 实验条件 实验对象 治疗周期 实验结果
Shen等[16] 中国 2016 试验组:湿房镜;对照组:0.9%不含防腐剂的生理盐水 30例干眼患者 90 min 眼部舒适度VAS、TMH、NIBUT及脂质层厚度随时间增加,在60 min时达到最大值,随后缓慢下降,但仍高于基线值
Moon等[18] 韩国 2016 试验组:个性化湿房镜;对照组:普通湿房镜 10名健康人 30 min个性化湿房镜,间隔30 min,30 min普通湿房镜 个性化湿房镜眼周平均湿度高于普通湿房镜,两者均高于环境湿度
Ogawa[27] 日本 2017 试验组:恒定风环境,湿房镜;对照组:无眼镜,常规框架眼镜 14例(28只眼)干眼症状患者 10 min 环境暴露10 min后,湿房镜组干燥症状VAS评分、瞬目频率及TBUT无明显变化
肖丽等[38] 中国 2017 试验组:湿房镜联合术后治疗;对照组:标准术后治疗 50例翼状胬肉手术患者 3个月 试验组OSDI低于对照组,Schirmer′s试验和TBUT高于对照组
赵燕等[46] 中国 2019 试验组:湿房镜联合常规治疗;对照组:常规治疗 60例暴露性角膜炎患者 1个月 试验组治愈率高于对照组,TBUT、TMH、LLT、角膜曲率及厚度差值优于对照组
陈振宗等[39] 中国 2020 试验组:湿房镜联合术后治疗;对照组:标准术后治疗 40例翼状胬肉手术患者 3个月 试验组OSDI、鼻侧球结膜充血、鼻侧睫状充血、球结膜充血评分低于对照组,NIBUT和TMH高于对照组
苏丽萍等[48] 中国 2022 试验组:湿房镜联合氟米龙滴眼液;对照组:氟米龙滴眼液 80例干眼患者 4周,4 h/d 治疗后试验组TBUT、Schirme′s试验结果升高且高于试验组,主观症状VAS评分、CFS评分、血清MMP-2、泪液IL-18、IL-1β及TNF-α降低且低于对照组
李莹等[42] 中国 2023 试验组:湿房镜;对照组:标准术后治疗 78例屈光手术患者 1个月 对照组术后NIBUT显著下降、OSDI升高,湿房镜组无明显变化;相比对照组,湿房镜组TMH较高,FS-LASIK术后彗差小
周吉彬等[33] 中国 2024 试验组:湿房镜联合氟米龙滴眼液;对照组:氟米龙滴眼液 80例干眼患者 2个月 试验组TBUT长于对照组,Schirmer′s试验、TMH及VFQ-25评分高于对照组,主观症状VAS评分、OSDI、结膜充血分级、TNF-α及MMP-2低于对照组
[1]
Britten-Jones AC, Wang MTM, Samuels I, et al. Epidemiology and risk factors of dry eye disease: considerations for clinical management[J]. Medicina (Kaunas), 2024, 60(9): 1458.
[2]
Liu Z, Pflugfelder SC. Corneal surface regularity and the effect of artificial tears in aqueous tear deficiency[J]. Ophthalmology, 1999, 106(5): 939-943.
[3]
Jones L, Downie LE, Korb D, et al. TFOS DEWS Ⅱ management and therapy report[J]. Ocul Surf, 2017, 15(3): 575-628.
[4]
Savar DE. A new approach to ocular moisture chambers[J]. J Pediatr Ophthalmol Strabismus, 1978, 15(1): 51-53.
[5]
Savar DE, Runacre P, Godfrey CM. Moisture chamber spectacles. A practical guide to their construction[J]. Arch Ophthalmol, 1979, 97(7): 1347-1348.
[6]
Tsubota K, Yamada M, Urayama K. Spectacle side panels and moist inserts for the treatment of dry-eye patients[J]. Cornea, 1994, 13(3): 197-201.
[7]
Cohen JM, Waiss B. Combination ptosis crutch and moisture chamber for management of progressive external ophthalmoplegia[J]. J Am Optom Assoc, 1997, 68(10): 663-667.
[8]
Jones L, Craig JP, Markoulli M, et al. TFOS DEWS Ⅲ management and therapy report[J]. Am J Ophthalmol, 2025, 279: 289-386.
[9]
中华医学会眼科学分会角膜病学组. 干眼临床诊疗专家共识(2013年)[J]. 中华眼科杂志201349(1):73-75.
[10]
中华医学会眼科学分会角膜病学组,中国医师协会眼科医师分会角膜病学组. 中国干眼临床诊疗专家共识(2024年)[J]. 中华眼科杂志202460(12):968-976.
[11]
Doan S, Chiambaretta F, Baudouin C. Evaluation of an eyelid warming device (Blephasteam) for the management of ocular surface diseases in France: the ESPOIR study[J]. J Fr Ophtalmol, 2014, 37(10): 763-772.
[12]
Magno MS, Olafsson J, Beining M, et al. Chambered warm moist air eyelid warming devices: a review[J]. Acta Ophthalmol, 2022, 100(5): 499-510.
[13]
Lam SM, Tong L, Duan X, et al. Longitudinal changes in tear fluid lipidome brought about by eyelid-warming treatment in a cohort of meibomian gland dysfunction[J]. J Lipid Res, 2014, 55(9): 1959-1969.
[14]
Ren Y, Chen J, Zheng Q, et al. Short-term effect of a developed warming moist chamber goggle for video display terminal-associated dry eye[J]. BMC Ophthalmol, 2018, 18(1): 33.
[15]
Mitra M, Menon GJ, Casini A, et al. Tear film lipid layer thickness and ocular comfort after meibomian therapy via latent heat with a novel device in normal subjects[J]. Eye (Lond), 2005, 19(6): 657-660.
[16]
Shen G, Qi Q, Ma X. Effect of moisture chamber spectacles on tear functions in dry eye disease[J]. Optom Vis Sci, 2016, 93(2): 158-164.
[17]
Davis RH, Van-Orman EW. Making moisture-chamber spectacles[J]. Am J Ophthalmol, 1982, 94(2): 256-257.
[18]
Moon CH, Kim JY, Kim MJ, et al. Effect of three-dimensional printed personalized moisture chamber spectacles on the periocular humidity[J]. J Ophthalmol, 2016, PMID: 5039181.
[19]
López-Miguel A, Tesón M, Martín-Montaňez V, et al. Dry eye exacerbation in patients exposed to desiccating stress under controlled environmental conditions[J]. Am J Ophthalmol, 2014, 157(4): 788-798.
[20]
Abusharha AA, Pearce EI. The effect of low humidity on the human tear film[J]. Cornea, 2013, 32(4): 429-434.
[21]
Begley C, Simpson T, Liu H, et al. Quantitative analysis of tear film fluorescence and discomfort during tear film instability and thinning[J]. Invest Ophthalmol Vis Sci, 2013, 54(4): 2645-2653.
[22]
Madden LC, Tomlinson A, Simmons PA. Effect of humidity variations in a controlled environment chamber on tear evaporation after dry eye therapy[J]. Eye Contact Lens, 2013, 39(2): 169-174.
[23]
McCulley JP, Aronowicz JD, Uchiyama E, et al. Correlations in a change in aqueous tear evaporation with a change in relative humidity and the impact[J]. Am J Ophthalmol, 2006, 141(4): 758-760.
[24]
Tsubota K. The effect of wearing spectacles on the humidity of the eye[J]. Am J Ophthalmol, 1989, 108(1): 92-93.
[25]
Li W, Graham AD, Selvin S, et al. Ocular surface cooling corresponds to tear film thinning and breakup[J]. Optom Vis Sci, 2015, 92(9): e248-256.、
[26]
Versura P, Giannaccare G, Fresina M, et al. Subjective discomfort symptoms are related to low corneal temperature in patients with evaporative dry eye[J]. Cornea, 2015, 34(9): 1079-1085.
[27]
Ogawa M, Dogru M, Toriyama N, et al. Evaluation of the effect of moist chamber spectacles in patients with dry eye exposed to adverse environmental conditions[J]. Eye Contact Lens, 2018, 44(6): 379-383.
[28]
Liu SH, Saldanha IJ, Abraham AG, et al. Topical corticosteroids for dry eye[J]. Cochrane Database Syst Rev, 2022, 10(10): CD015070.
[29]
Lin T, Gong L. Topical fluorometholone treatment for ocular dryness in patients with Sjögren syndrome: a randomized clinical trial in China[J]. Medicine (Baltimore), 2015, 94(7): e551.
[30]
Pinto-Fraga J, López-Miguel A, González-García MJ, et al. Topical fluorometholone protects the ocular surface of dry eye patients from desiccating stress: a randomized controlled clinical trial[J]. Ophthalmology, 2016, 123(1): 141-153.
[31]
Dillard D, Reisig DD, Schug HT, et al. Moisture and soil type are primary drivers of Helicoverpa zea (Lepidoptera: Noctuidae) pupation[J]. Environ Entomol, 2023, 52(5): 847-852.
[32]
Kass M, Cheetham J, Duzman E, et al. The ocular hypertensive effect of 0.25% fluorometholone in corticosteroid responders[J]. Am J Ophthalmol, 1986, 102(2): 159-163.
[33]
Zhou J, Sun Y, Cheng Y, et al. Efficacy of moisture chamber goggles combined with fluorometholone eye drops on visual function and oxidative stress in patients with dry eye disease[J]. Am J Transl Res, 2024, 16(12): 7782-7791.
[34]
Naderi K, Gormley J, O′Brart D. Cataract surgery and dry eye disease: A review[J]. Eur J Ophthalmol, 2020, 30(5): 840-855.
[35]
Miura M, Inomata T, Nakamura M, et al. Prevalence and characteristics of dry eye disease after cataract surgery: a systematic review and meta-analysis[J]. Ophthalmol Ther, 2022, 11(4): 1309-1332.
[36]
Chang J, Cao Q, Yong J, et al. The effect of different pterygium surgery techniques on the ocular surface parameters in different durations: a systematic review and meta-analysis[J]. Graefes Arch Clin Exp Ophthalmol, 2024, 262(5): 1383-1396.
[37]
Lu P, Chen X, Kang Y, et al. Pterygium in Tibetans: a population-based study in China[J]. Clin Exp Ophthalmol, 2007, 35(9): 828-833.
[38]
肖丽,沈满意,马晓萍. 湿房镜对翼状胬肉术后泪膜稳定性的影响[J]. 临床眼科杂志201725(5):450-452.
[39]
陈振宗,姚鹏翔,洪玉芳,等. 湿房镜对翼状胬肉切除术后眼表的影响[J]. 中国临床医学202027(3):461-464.
[40]
Toda I. Dry eye after LASIK[J]. Invest Ophthalmol Vis Sci, 2018, 59(14): DES109-DES115.
[41]
Jing D, Liu Y, Chou Y, et al. Change patterns in the corneal sub-basal nerve and corneal aberrations in patients with dry eye disease: An artificial intelligence analysis[J]. Exp Eye Res, 2022, 215: 108851.
[42]
Huang T, Wang Y, Zhu Z, et al. Moisture chamber goggles for the treatment of postoperative dry eye in patients receiving SMILE and FS-LASIK surgery[J]. BMC Ophthalmol, 2023, 23(1): 501.
[43]
Chen Y, He J, Wu Q, et al. Prevalence and risk factors of exposure keratopathy among critically ill patients: a systematic review and meta-analysis[J]. Nurs Open, 2024, 11(1): e2061.
[44]
Kousha O, Kousha Z, Paddle J. Incidence, risk factors and impact of protocolised care on exposure keratopathy in critically ill adults: a two-phase prospective cohort study[J]. Crit Care, 2018, 22(1): 5.
[45]
Alansari MA, Hijazi MH, Maghrabi KA. Making a difference in eye care of critically ill patients[J]. J Intensive Care Med, 2015, 30(6): 311-317.
[46]
赵燕,李东,张建勇,等. 功能性湿房镜对暴露性角膜炎角膜及泪膜稳定性的影响[J]. 中国继续医学教育201911(7):95-96.
[47]
赵慧,刘祖国,肖辛野,等. 非加热型湿房镜治疗干眼的临床疗效[J]. 中华眼视光学与视觉科学杂志201416(9):517-521.
[48]
苏丽萍,刘郡,王珏. 湿房镜联合氟米龙滴眼液治疗干眼症疗效及对患者泪膜稳定性和血清基质金属蛋白酶-2的影响[J]. 陕西医学杂志202251(5):586-590.
[49]
Bzovey B, Ngo W. Eyelid warming devices: safety, efficacy, and place in therapy[J]. Clin Optom (Auckl), 2022, 14: 133-147.
[50]
Matsumoto Y, Dogru M, Goto E, et al. Efficacy of a new warm moist air device on tear functions of patients with simple meibomian gland dysfunction[J]. Cornea, 2006, 25(6): 644-650.
[51]
Benitez-Del-Castillo JM, Kaercher T, Mansour K, et al. Evaluation of the efficacy, safety, and acceptability of an eyelid warming device for the treatment of meibomian gland dysfunction[J]. Clin Ophthalmol, 2014, 8: 2019-2027.
[52]
Sim HS, Petznick A, Barbier S, et al. A randomized, controlled treatment trial of eyelid-warming therapies in meibomian gland dysfunction[J]. Ophthalmol Ther, 2014, 3(1-2): 37-48.
[1] 丁雪薇, 买买提吐逊·吐尔地. 富血小板血浆治疗颞下颌关节骨关节病的机制与临床应用[J/OL]. 中华口腔医学研究杂志(电子版), 2025, 19(06): 424-428.
[2] 中华医学会器官移植学分会肝移植学组, 中国医师协会器官移植医师分会. 中国扩大标准供肝移植临床应用指南(2025版)[J/OL]. 中华移植杂志(电子版), 2025, 19(02): 65-75.
[3] 李逸凡, 洪源, 熊茂明. 基于3D Slicer软件的术前规划在腹壁纤维瘤手术中的临床应用价值:一项单中心前瞻性分析[J/OL]. 中华疝和腹壁外科杂志(电子版), 2025, 19(03): 286-291.
[4] 鲁宇青, 李大伟, 邹剑峰, 胡子龙, 李哲, 李琦, 张丽媛, 霍萌, 沈玥, 帅维正. 新型俯卧位翻身辅助装置在急性呼吸窘迫综合征患者中的临床应用[J/OL]. 中华肺部疾病杂志(电子版), 2025, 18(05): 757-761.
[5] 林敏杰, 吕艳玲, 姚羽, 王艳泓, 邹如意, 唐成. 支气管镜下钬激光技术在中心气道狭窄中的临床应用[J/OL]. 中华肺部疾病杂志(电子版), 2025, 18(02): 315-320.
[6] 陈慧, 田森, 张伟, 董宇超, 白冲, 王琴. 内科胸腔镜检查专用床单在不明原因胸腔积液患者中的临床应用[J/OL]. 中华肺部疾病杂志(电子版), 2025, 18(02): 300-303.
[7] 中华医学会呼吸病学分会肺功能学组. 成人肺功能检查技术进展及临床应用推荐指南(2025版)[J/OL]. 中华肺部疾病杂志(电子版), 2025, 18(02): 197-212.
[8] 马逸夫, 孙芳玲, 刘婷婷, 田欣, 王文. 神经干细胞永生化的机制及其应用进展[J/OL]. 中华细胞与干细胞杂志(电子版), 2025, 15(04): 251-256.
[9] 俞少俊, 关旭, 郑见宝, 于冠宇, 刘恒辰, 王贵玉, 张卫, 韩方海, 王丹波, 周海涛, 胡军红, 彭健, 姚宏亮, 何庆泗, 郑阳春, 康亮, 王振宁, 江波, 熊治国, 马丹, 孙学军, 李云峰, 李永翔, 韦烨, 丁志杰, 周主青, 汤庆超, 李耀平, 薛芳沁, 刘萍, 刘东宁, 中国NOSES联盟, 中国抗癌协会NOSES专委会, 中国医师协会结直肠肿瘤专业委员会NOSES学组, 李太原, 丁克峰, 王锡山. 中国12余万例经自然腔道取标本手术(NOSES)临床应用现况分析[J/OL]. 中华结直肠疾病电子杂志, 2025, 14(06): 497-508.
[10] 王宇辰, 潘星辰, 周军, 于欣立, 丁一, 周欣佐, 何奕璇, 楚文博, 韩镒泽, 郭安琪, 刘子源, 李学民, 丁立. 急性低压缺氧暴露对人眼泪膜稳定性影响的临床研究[J/OL]. 中华眼科医学杂志(电子版), 2025, 15(05): 276-281.
[11] 王晓宇, 段虹宇, 陈嘉玮, 秦锐, 齐虹. 0.05%环孢素A滴眼液治疗糖尿病相关干眼的临床研究[J/OL]. 中华眼科医学杂志(电子版), 2025, 15(03): 149-154.
[12] 陈丽丽, 陈笑语, 戴琦, 吴双庆, 付庆东. 睑板腺功能障碍发病机制的研究进展[J/OL]. 中华眼科医学杂志(电子版), 2025, 15(02): 124-128.
[13] 文皓男, 闻雅, 吴彬阁, 吴倩如, 刘晶, 接英, 田磊. 射频技术用于睑板腺功能障碍相关干眼治疗安全性与有效性的临床研究[J/OL]. 中华眼科医学杂志(电子版), 2025, 15(02): 87-92.
[14] 崔砚, 徐超, 刘伟, 徐江, 李芳家, 王洋洋, 邱文乔, 郭莉丽, 袁瑛, 窦维蓓, 徐如祥. 植入式脑机接口技术临床应用及其科技伦理[J/OL]. 中华神经创伤外科电子杂志, 2025, 11(05): 273-279.
[15] 黄亮, 徐彬翔, 王凯, 李龙, 何琳, 高强, 赵军, 刘天. 时间干涉刺激的发展:从技术原理到临床应用[J/OL]. 中华脑血管病杂志(电子版), 2025, 19(05): 353-363.
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?