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中华眼科医学杂志(电子版) ›› 2025, Vol. 15 ›› Issue (02) : 124 -128. doi: 10.3877/cma.j.issn.2095-2007.2025.02.011

综述

睑板腺功能障碍发病机制的研究进展
陈丽丽1,2, 陈笑语3, 戴琦3, 吴双庆1,3,, 付庆东4   
  1. 1. 310053 杭州,浙江中医药大学研究生院
    2. 310024 浙江省杭州西湖之江眼科医院眼表疾病科
    3. 325027 温州医科大学附属眼视光医院 国家眼耳鼻喉疾病临床医学研究中心(眼部疾病)眼表疾病科
    4. 310000 浙江省杭州朝聚眼科医院功检科
  • 收稿日期:2025-02-19 出版日期:2025-04-28
  • 通信作者: 吴双庆
  • 基金资助:
    浙江省中医药管理局共建科技计划重点项目(GZYZJ-KJ-23086)

Research advances in the pathogenesis of meibomian gland dysfunction

Lili Chen1,2, Xiaoyu Chen3, Qi Dai3, Shuangqing Wu1,3,, Qingdong Fu4   

  1. 1. Graduate School,Zhejiang Chinese Medical University,Hangzhou 310053,China
    2. Department of Ocular Surface Diseases,Hangzhou Xihu Eye Hospital at Zhijiang,Hangzhou 310024,China
    3. Department of Ocular Surface Diseases,National Clinical Research Center for Ocular Diseases,Eye Hospital,Wenzhou Medical University,Wenzhou 325027,China
    4. Department of Functional Examination,Hangzhou Chaoju Ophthalmic Hospital of Zhejiang Province,Hangzhou 310000,China
  • Received:2025-02-19 Published:2025-04-28
  • Corresponding author: Shuangqing Wu
引用本文:

陈丽丽, 陈笑语, 戴琦, 吴双庆, 付庆东. 睑板腺功能障碍发病机制的研究进展[J/OL]. 中华眼科医学杂志(电子版), 2025, 15(02): 124-128.

Lili Chen, Xiaoyu Chen, Qi Dai, Shuangqing Wu, Qingdong Fu. Research advances in the pathogenesis of meibomian gland dysfunction[J/OL]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2025, 15(02): 124-128.

睑板腺功能障碍(MGD)是干眼(DED)的常见原因。它是一种慢性且弥漫性病变,属于临床高发的眼表疾病。MGD的病因比较复杂,目前尚无统一定论。明确MGD的发病机制对临床诊断与治疗至关重要。近年来,国内外对有关MGD发病机制的研究已取得部分进展,现综述如下。

Meibomian gland dysfunction(MGD)is the most prevalent cause of dry eye disease(DED).It is a chronic,diffuse condition that falls under ocular surface diseases and is highly prevalent in clinical practice.The etiology of MGD is multifactorial,and currently,there is no consensus on its exact origins.Elucidating the pathogenesis of MGD is crucial for improving clinical diagnosis and treatment strategies.Recently,it has been demonstrated that the partial pathogenesis of MGD was investigated both domestically and internationally,and was reviewed comprehensively in this paper.

图1 光学显微镜下苏木精-伊红染色人睑板腺显微照像(×200) 图中可见睑板腺由一个长条形中央导管组成,周围环绕着许多圆形腺泡(箭头所指处)
图2 裂隙灯显微镜下睑板腺功能障碍患者的彩色照像和红外线成像 图A示蠕形螨睑缘炎伴睑板腺功能障碍患者睫毛根部见袖套样改变,上下睑缘充血、圆钝,新生血管长入(×16);图B示眼表菌群改变致重度睑板腺萎缩患者睑板腺红外线成像(×40)
表1 睑板腺功能障碍主要危险因素及其分子机制的文献汇总
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