| ［1］ |
Golden MI，Meyer JJ，Zeppieri M，et al.Dry Eye Syndrome［M］.Treasure Island（FL）：StatPearls Publishing，2024.
|
| ［2］ |
Subcommittee of the International. The definition and classification of dry eye disease：report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop（2007）［J］.The Ocular Surface，2007，5（2）：75-92.
|
| ［3］ |
Beydon M，McCoy S，Nguyen Y，et al.Epidemiology of Sjögren syndrome［J］.Nature Reviews.Rheumatology，2024，20（3）：158-169.
|
| ［4］ |
Safir M，Twig G，MimouniM.Dry eye diseasemanagement［J］.BMJ（Clinical research ed.），2024，384：e077344.
|
| ［5］ |
Clayton JA.Dry Eye［J］.The New England Journal of Medicine［J］.2018，378（23）：2212-2223.
|
| ［6］ |
Jones L，Downie LE， Korb D， et al. TFOS DEWS II Managementand Therapy Report［J］.The Ocular Surface，2017，15（3）：575-628.
|
| ［7］ |
Tsubota K，Pflugfelder SC，Liu Z，et al.Defining Dry Eye from a Clinical Perspective［J］.International Journal of Molecular Sciences，2020，21（23）：9271.
|
| ［8］ |
Grenham S，Clarke G，Cryan JF，et al.Brain-gut-microbe communication in health and disease［J］. Frontiers in Physiology，2011，2：94.
|
| ［9］ |
Valentin C，Brito Rodrigues P，Verce M，et al.Maternal probiotic exposure enhances CD8 T cell protective neonatal immunity and modulates offspringmetabolome to control influenza virus infection［J］.GutMicrobes，2025，17（1）：2442526.
|
| ［10］ |
Rui C，Chen C， Chen J. Interactions of commensal and pathogenicmicroorganismswith themucus layer in the colon［J］.Gut Microbes，2020，11（4）：680-690.
|
| ［11］ |
Wang Y，Wei J，Zhang W，et al.Gut dysbiosis in rheumatic diseases： A systematic review and meta-analysis of 92 observational studies［J］.EBioMedicine，2022，80：104055.
|
| ［12］ |
Clancy RM，Marion MC，Ainsworth HC，etal.Gutdysbiosisand the clinical spectrum in anti-Ro positivemothers of children with neonatal lupus［J］.Gut Microbes，2022，14（1）：2081474.
|
| ［13］ |
Hill JH，Round JL.SnapShot：Microbiota effects on host physiology［J］.Cell，2021，184（10）：2796-2796.
|
| ［14］ |
Mayer EA，Nance K，Chen S.The Gut-Brain Axis［J］.Annual Review of Medicine，2022，73：439-453.
|
| ［15］ |
Ford AC，Sperber AD，Corsetti M，et al.Irritable bowel syndrome［J］. Lancet（London， England），2020，396（10263）：1675-1688.
|
| ［16］ |
Nguyen Y，Rudd Zhong Manis J，Ronczkowski NM，et al.Unveiling the gut-eye axis：how microbial metabolites influence ocular health and disease［J］.Frontiers in Medicine，2024，11：1377186.
|
| ［17］ |
Jin Q，Wang S，Yao Y，et al.The gut-eye axis：from brain neurodegenerative diseases to age-related macular degeneration［J］. Neural Regeneration Research， 2025， 20（10）：2741-2757.
|
| ［18］ |
Fu X，Tan H，Huang L，etal.Gutmicrobiota and eye diseases：a bibliometric study and visualization analysis［J］.Frontiers in Cellular and Infection Microbiology，2023，13：1225859.
|
| ［19］ |
Alfuzaie R.The Link Between Gastrointestinal Microbiome and Ocular Disorders［J］.Clinical Ophthalmology（Auckland，N.Z.），2023，17：2133-2140.
|
| ［20］ |
Cavuoto KM，Banerjee S，Galor A.Relationship between the microbiome and ocular health［J］.The Ocular Surface，2019，17（3）：384-392.
|
| ［21］ |
Chen P，Tang X.Gut Microbiota as Regulators of Th17/Treg Balance in Patients With Myasthenia Gravis［J］.Frontiers in Immunology，2021，12：803101.
|
| ［22］ |
Horai R，Zárate-Bladés CR， Dillenburg-Pilla P， et al.Microbiota-Dependent Activation of an Autoreactive T Cell Receptor Provokes Autoimmunity in an Immunologically Privileged Site［J］.Immunity，2015，43（2）：343-353.
|
| ［23］ |
Nakamura YK，Metea C，Karstens L，et al.Gut Microbial Alterations Associated With Protection From Autoimmune Uveitis［J］.Investigative Ophthalmology＆Visual Science，2016，57（8）：3747-3758.
|
| ［24］ |
Yang L，Xiang Z，Zou J，et al.Comprehensive Analysis of the Relationships Between the Gut Microbiota and Fecal Metabolome in Individuals With Primary Sjogren's Syndrome by 16S rRNA Sequencing and LC-MS-Based Metabolomics［J］.Frontiers in Immunology，2022，13：874021.
|
| ［25］ |
Moon J，Choi SH，Yoon CH，etal.Gut dysbiosis is prevailing in Sjögren's syndrome and is related to dry eye severity［J］.PloS One，2020，15（2）：e0229029.
|
| ［26］ |
Li Y，Li Z，Sun W，et al.Characteristics of gut microbiota in patientswith primary Sjögren's syndrome in Northern China［J］.PLOSONE，2022，17（11）：e0277270.
|
| ［27］ |
Wang X，Pang K，Wang J，etal.Microbiota dysbiosis in primary Sjögren 's syndrome and the ameliorative effect of hydroxychloroquine［J］.Cell Reports，2022，40（11）：111352.
|
| ［28］ |
van der Meulen TA，Harmsen HJM，Vila AV，etal.Shared gut，but distinct oral microbiota composition in primary Sjögren's syndrome and systemic lupus erythematosus［J］.Journal of Autoimmunity，2019，97：77-87.
|
| ［29］ |
Cano-Ortiz A，Laborda-Illanes A，Plaza-Andrades I，et al.Connection between the Gut Microbiome，Systemic Inflammation，Gut Permeability and FOXP3 Expression in Patients with Primary Sjögren's Syndrome［J］.International Journal of Molecular Sciences，2020，21（22）：8733.
|
| ［30］ |
Jia XM，Wu BX，Chen B，et al.Compositional and functional aberrance of the gut microbiota in treatment-naïve patients with primary Sjögren's syndrome［J］.Journal of Autoimmunity，2023，141：103050.
|
| ［31］ |
Zaheer M，Wang C，Bian F，et al.Protective role of commensal bacteria in Sjögren Syndrome［J］.Journal of Autoimmunity，2018，93：45-56.
|
| ［32］ |
He S，LiH，Yu Z，etal.The GutMicrobiome and Sex Hormone-Related Diseases［J］. Frontiers in Microbiology， 2021，12：711137.
|
| ［33］ |
Xuan Y，Zhang X，Wu H.Impact of sex differences on the clinical presentation，pathogenesis，treatment and prognosis of Sjögren's syndrome［J］.Immunology，2024，171（4）：513-524.
|
| ［34］ |
Mazziotta C，Tognon M，Martini F，et al.Probiotics Mechanism of Action on Immune Cells and Beneficial Effects on Human Health［J］.Cells，2023，12（1）：184.
|
| ［35］ |
Guarino MPL，Altomare A，Emerenziani S，etal.Mechanisms of Action of Prebiotics and Their Effects on Gastro-Intestinal Disorders in Adults［J］.Nutrients，2020，12（4）：1037.
|
| ［36］ |
Sorboni SG，Moghaddam HS，Jafarzadeh-Esfehani R，et al.A Comprehensive Review on the Role of the Gut Microbiome in Human Neurological Disorders［J］. Clinical Microbiology Reviews，2022，35（1）：e0033820.
|
| ［37］ |
Cheng LH，Liu YW，Wu CC，et al.Psychobiotics in mental health，neurodegenerative and neurodevelopmental disorders［J］.Journal of Food and Drug Analysis，2019，27（3）：632-648.
|
| ［38］ |
Rezaei Asl Z，SepehriG，SalamiM.Probiotic treatment improves the impaired spatial cognitive performance and restores synaptic plasticity in an animal model of Alzheimer's disease［J］.Behavioural Brain Research，2019，376：112183.
|
| ［39］ |
Kwon HK， Kim GC， Young K， et al. Amelioration of experimental autoimmune encephalomyelitis by probiotic mixture is mediated by a shift in T helper cell immune response［J］.Clinical immunology（Orlando， Fla.），2013，146（3）：217-227.
|
| ［40］ |
Lee K， Gwon H， Shim JJ， et al. Consumption of Limosilactobacillus fermentum Inhibits Corneal Damage and Inflammation in Dry Eye Disease Mouse Model through Regulating the Gut Microbiome［J］.International Journal of Molecular Sciences，2024，25（6）：3528.
|
| ［41］ |
Choi SH，Oh JW，Ryu JS，et al.IRT5 Probiotics Changes Immune Modulatory Protein Expression in the Extraorbital Lacrimal Glands of an Autoimmune Dry Eye Mouse Model［J］.Investigative Ophthalmology ＆ Visual Science， 2020， 61（3）：42.
|
| ［42］ |
Moon J，Ryu JS，Kim JY，et al.Effectof IRT5 probiotics on dry eye in the experimental dry eye mouse model［J］.PloS One，2020，15（12）：e0243176.
|
| ［43］ |
Tavakoli A，MarkoulliM，Papas E，et al. The Impact of Probiotics and Prebiotics on Dry Eye Disease Signs and Symptoms［J］.Journal of Clinical Medicine，2022，11（16）：4889.
|
| ［44］ |
Napolitano P，Filippelli M，D'andrea L，et al.Probiotic Supplementation Improved Acute Anterior Uveitis of 3-Year Duration：A Case Report［J］.Am J Case Rep，2021，22：e931321.
|
| ［45］ |
Zhang F，Luo W，Shi Y，et al.Should we standardize the 1，700-year-old fecal microbiota transplantation？ ［J］. The American Journal of Gastroenterology， 2012， 107（11）：1755-1756.
|
| ［46］ |
Zhanel GG，Rotem Keynan R，Yoav Keynan Y，et al.The role of Fecal Microbiota Transplantation（FMT）in treating patients with multiple sclerosis［J］.Expert Rev Neurother，2023，23（10）：921-930.
|
| ［47］ |
Yang D，Zhao D，Ali Shah SZ，et al.The Role of the Gut Microbiota in the Pathogenesis of Parkinson's Disease［J］.Frontiers in Neurology，2019，10：1155.
|
| ［48］ |
Czepiel J，DróždžM，Pituch H，et al.Clostridium difficile infection：review［J］.European Journal of Clinical Microbiology＆ Infectious Diseases：Official Publication of the European Society of Clinical Microbiology，2019，38（7）：1211-1221.
|
| ［49］ |
Parker A，Romano S，Ansorge R，etal.Fecalmicrobiota transfer between young and aged mice reverses hallmarks of the aging gut，eye，and brain［J］.Microbiome，2022，10（1）：68.
|
| ［50］ |
Watane A，Cavuoto KM，Rojas M，et al.Fecal Microbial Transplant in Individuals With Immune-Mediated Dry Eye［J］.American Journal of Ophthalmology，2022，233：90-100.
|
| ［51］ |
Labetoulle M，Baudouin C，Benitez Del Castillo JM，et al.How gutmicrobiotamay impact ocular surface homeostasis and related disorders［J］.Progress in Retinal and Eye Research，2024，100：101250.
|
| ［52］ |
de Paiva CS，Jones DB，Stern ME，et al.Altered Mucosal Microbiome Diversity and Disease Severity in Sjögren Syndrome［J］.Scientific Reports，2016，6：23561.
|
| ［53］ |
Vergroesen JE，Jarrar ZA，Weiss S，et al.Glaucoma Patients Have a Lower Abundance of Butyrate-Producing Taxa in the Gut［J］.Investigative Ophthalmology＆Visual Science，2024，65（2）：7.
|
| ［54］ |
Chen X，Su W，Wan T，et al.Sodium butyrate regulates Th17/Treg cell balance to ameliorate uveitis via the Nrf2/HO-1 pathway［J］.Biochemical Pharmacology，2017，142：111-119.
|
| ［55］ |
Kim DS，Woo JS，Min HK，etal.Short-chain fatty acid butyrate induces IL-10-producing B cells by regulating circadian-clockrelated genes to ameliorate Sjögren's syndrome［J］.Journal of Autoimmunity，2021，119：102611.
|
| ［56］ |
Nagatomo R，Kaneko H，Kamatsuki S，et al.Short-chain fatty acids profiling in biological samples from a mouse model of Sjögren's syndrome based on derivatized LC-MS/MS assay［J］.Journal of Chromatography.B，Analytical Technologies in the Biomedical and Life Sciences，2022，1210：123432.
|
| ［57］ |
Zhang Y，Wu Y，Guan Y，et al.Maidong Dishao Decoction mitigates submandibular gland injury in NOD mice through modulation of gutmicrobiota and restoration of Th17/Treg immune balance［J］.Heliyon，2024，10（21）：e38421.
|