切换至 "中华医学电子期刊资源库"

中华眼科医学杂志(电子版) ›› 2023, Vol. 13 ›› Issue (05) : 296 -300. doi: 10.3877/cma.j.issn.2095-2007.2023.05.008

综述

长链非编码核糖核酸心肌梗死转录本在视网膜缺血性疾病中的研究进展
王志斌, 周小瑞, 底煜()   
  1. 110004 沈阳,中国医科大学第二临床学院2022级研究生
    110004 沈阳,中国医科大学附属盛京医院眼科
  • 收稿日期:2023-09-01 出版日期:2023-10-28
  • 通信作者: 底煜
  • 基金资助:
    国家自然科学基金项目(81600747); 辽宁省教育厅基金项目(QNZR2020010); 沈阳市科技厅项目(21-173-9-52)

Research progress of LncRNA myocardial infarction transcripts in retinal ischemic diseases

Zhibin Wang, Xiaorui Zhou, Yu Di()   

  1. Master′s degree 2022, The Second Clinical Medical College, China Medical University, Shenyang 110004, China
    Department of Ophthalmology, Shengjing Hospital of China Medical University, Shenyang 110004, China
  • Received:2023-09-01 Published:2023-10-28
  • Corresponding author: Yu Di
引用本文:

王志斌, 周小瑞, 底煜. 长链非编码核糖核酸心肌梗死转录本在视网膜缺血性疾病中的研究进展[J]. 中华眼科医学杂志(电子版), 2023, 13(05): 296-300.

Zhibin Wang, Xiaorui Zhou, Yu Di. Research progress of LncRNA myocardial infarction transcripts in retinal ischemic diseases[J]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2023, 13(05): 296-300.

视网膜缺血性疾病包括视网膜动脉阻塞、视网膜静脉阻塞、糖尿病视网膜病变及早产儿视网膜病变等常见疾病,其发病机制主要与动脉粥样硬化和视网膜新生血管有关,此类疾病可造成患者视力的严重丧失,是一类复杂且具有挑战性的疾病。当前,长链非编码核糖核酸(LncRNA)是生物学研究的热门领域之一。近年来,许多学者开展了心肌梗死转录本(MIAT)在视网膜缺血性疾病中作用的研究。本文中笔者就LncRNA MIAT在组织细胞增殖、凋亡、氧化应激、神经变性、免疫、炎症反应、焦亡、铁死亡、自噬及上皮间质转化等多种病理过程中的作用机制进行综述。

Retinal ischemic diseases include retinal artery occlusion, retinal vein occlusion, diabetes retinopathy, retinopathy of prematurity and other common diseases. Its pathogenesis is mainly related to atherosclerosis and retinal neovascularization. Such diseases can cause severe loss of vision in patients, and are a group of complex and challenging diseases. Currently, long chain non coding ribonucleic acid (LncRNA) is one of the hot research areas in biology. In recent years, the role of myocardial infarction transcripts (MIATs) in retinal ischemic diseases has paid more attention for many scholars. In this paper, the mechanisms of LncRNA MIAT in various pathological processes such as tissue cell proliferation, apoptosis, oxidative stress, neurodegeneration, immunity, inflammatory response, pyroptosis, ferroptosis, autophagy, and epithelial mesenchymal transition were reviewed.

图1 长链非编码核糖核酸心肌梗死转录本作用机制示意图
表1 LncRNA MIAT在视网膜和血管疾病中的下游靶基因
[1]
Cao H, Wahlestedt C, Kapranov P. Strategies to Annotate and Characterize Long Noncoding RNAs: Advantages and Pitfalls[J]. Trends Genet, 2018, 34(9): 704-721.
[2]
Elkon R, Agami R. Characterization of noncoding regulatory DNA in the human genome[J]. Nat Biotechnol, 2017, 35(8): 732-746.
[3]
Ishii N, Ozaki K, Sato H, et al. Identification of a novel non-coding RNA, MIAT, that confers risk of myocardial infarction[J]. J Hum Genet, 2006, 51(12): 1087-1099.
[4]
Spencer BG, Estevez JJ, Liu E, et al. Pericytes, inflammation, and diabetic retinopathy[J]. Inflammopharmacology, 2020, 28(3): 697-709.
[5]
Yu X, Ma X, Lin W, et al. Long noncoding RNA MIAT regulates primary human retinal pericyte pyroptosis by modulating miR-342-3p targeting of CASP1 in diabetic retinopathy[J]. Exp Eye Res, 2021, 202: 108300.
[6]
Yu C, Yang K, Meng X, et al. Downregulation of Long Noncoding RNA MIAT in the Retina of Diabetic Rats with Tail-vein Injection of Human Umbilical-cord Mesenchymal Stem Cells[J]. Int J Med Sci, 2020, 17(5): 591-598.
[7]
Hammes HP. Diabetic retinopathy: hyperglycaemia, oxidative stress and beyond[J]. Diabetologia, 2018, 61(1): 29-38.
[8]
Gao Y, Yue J, Huang Z. LncRNA MIAT Mediates ox-LDL-Induced Endothelial Cell Injury Via miR-206/RAB22A Axis[J]. J Surg Res, 2021, 265: 303-312.
[9]
Zhang J, Chen M, Chen J, et al. Long non-coding RNA MIAT acts as a biomarker in diabetic retinopathy by absorbing miR-29b and regulating cell apoptosis[J]. Biosci Rep, 2017, 37(2): 36.
[10]
Li Q, Pang L, Yang W, et al. Long Non-Coding RNA of Myocardial Infarction Associated Transcript (LncRNA-MIAT) Promotes Diabetic Retinopathy by Upregulating Transforming Growth Factor-β1 (TGF-β1) Signaling[J]. Med Sci Monit, 2018, 24: 9497-9503.
[11]
Zhang J, Chen C, Wu L, et al. C-myc contributes to the release of Müller cells-derived proinflammatory cytokines by regulating LncRNA MIAT/XNIP pathway[J]. Int J Biochem Cell Biol, 2019, 114: 105574.
[12]
Zhou Y, Ma W, Bian H, et al. Long non-coding RNA MIAT/miR-148b/PAPPA axis modifies cell proliferation and migration in ox-LDL-induced human aorta vascular smooth muscle cells[J]. Life Sci, 2020, 256: 117852.
[13]
Ma G, Bi S, Zhang P. Long non-coding RNA MIAT regulates ox-LDL-induced cell proliferation, migration and invasion by miR-641/STIM1 axis in human vascular smooth muscle cells[J]. BMC Cardiovasc Disord, 2021, 21(1): 248.
[14]
Ye ZM, Yang S, Xia YP, et al. LncRNA MIAT sponges miR-149-5p to inhibit efferocytosis in advanced atherosclerosis through CD47 upregulation[J]. Cell Death Dis, 2019, 10(2): 138.
[15]
Yan B, Yao J, Liu JY, et al. LncRNA-MIAT regulates microvascular dysfunction by functioning as a competing endogenous RNA[J]. Circ Res, 2015, 116(7):1143-1156.
[16]
Zhong X, Ma X, Zhang L, et al. MIAT promotes proliferation and hinders apoptosis by modulating miR-181b/STAT3 axis in ox-LDL-induced atherosclerosis cell models[J]. Biomed Pharmacother, 2018, 97: 1078-1085.
[17]
Ma H, Zheng L, Qin H, et al. Myocardial Infarction-associated Transcript Knockdown Inhibits Cell Proliferation, Migration, and Invasion Through miR-490-3p/Intercellular Adhesion Molecule 1 Axis in Oxidized Low-density Lipoprotein-induced Vascular Smooth Muscle Cells[J]. J Cardiovasc Pharmacol, 2020, 76(5): 617-626.
[18]
Nawaz IM, Rezzola S, Cancarini A, et al. Human vitreous in proliferative diabetic retinopathy: Characterization and translational implications[J]. Prog Retin Eye Res, 2019, 72: 100756.
[19]
Alfaifi M, Ali BM, Alshahrani MY, et al. Circulating long non-coding RNAs NKILA, NEAT1, MALAT1, and MIAT expression and their association in type 2 diabetes mellitus[J]. BMJ Open Diabetes Res Care, 2021, 9(1): e001821.
[20]
Sharma RA, Newman NJ, Biousse V. New concepts on acute ocular ischemia[J]. Curr Opin Neurol, 2019, 32(1): 19-24.
[21]
Ørskov M, Vorum H, Larsen TB, et al. Clinical risk factors for retinal artery occlusions: a nationwide case-control study[J]. Int Ophthalmol, 2022, 42(8): 2483-2491.
[22]
Lu J, Huang Y, Zhang X, et al. Noncoding RNAs involved in DNA methylation and histone methylation, and acetylation in diabetic vascular complications[J]. Pharmacol Res, 2021, 170: 105520.
[23]
Dudley AC, Griffioen AW. Pathological angiogenesis: mechanisms and therapeutic strategies[J]. Angiogenesis, 2023, 26(3): 313-347.
[24]
Dong X, Lei Y, Yu Z, et al. Exosome-mediated delivery of an anti-angiogenic peptide inhibits pathological retinal angiogenesis[J]. Theranostics, 2021, 11(11): 5107-5126.
[25]
Yu B, Wang S. Angio-LncRs: LncRNAs that regulate angiogenesis and vascular disease[J]. Theranostics, 2018, 8(13): 3654-3675.
[26]
Bai Y, Wang W, Zhang Y, et al. LncRNA MIAT suppression alleviates corneal angiogenesis through regulating miR-1246/ACE[J]. Cell Cycle, 2019, 18(6-7): 661-669.
[27]
Bountali A, Tonge DP, Mourtada-Maarabouni M. RNA sequencing reveals a key role for the long non-coding RNA MIAT in regulating neuroblastoma and glioblastoma cell fate[J]. Int J Biol Macromol, 2019, 130: 878-891.
[28]
Deng W, Fan C, Shen R, et al. Long noncoding MIAT acting as a ceRNA to sponge microRNA-204-5p to participate in cerebral microvascular endothelial cell injury after cerebral ischemia through regulating HMGB1[J]. J Cell Physiol, 2020, 235(5): 4571-4586.
[29]
Ji L, Tian H, Webster KA, et al. Neurovascular regulation in diabetic retinopathy and emerging therapies[J]. Cell Mol Life Sci, 2021, 78(16): 5977-5985.
[30]
Simó R, Simó-Servat O, Bogdanov P, et al. Neurovascular Unit: A New Target for Treating Early Stages of Diabetic Retinopathy[J]. Pharmaceutics, 2021, 13(8): 1320.
[31]
Jindal V. Neurodegeneration as a primary change and role of neuroprotection in diabetic retinopathy[J]. Mol Neurobiol, 2015, 51(3): 878-884.
[32]
Li EY, Zhao PJ, Jian J, et al. LncRNA MIAT overexpression reduced neuron apoptosis in a neonatal rat model of hypoxic-ischemic injury through miR-211/GDNF[J]. Cell Cycle, 2019, 18(2): 156-166.
[33]
Guo X, Wang Y, Zheng D, et al. LncRNA-MIAT promotes neural cell autophagy and apoptosis in ischemic stroke by up-regulating REDD1[J]. Brain Res, 2021, 1763: 147436.
[34]
Ao H, Li H, Zhao X, et al. TXNIP positively regulates the autophagy and apoptosis in the rat müller cell of diabetic retinopathy[J]. Life Sci, 2021, 267: 118988.
[35]
Kong H, Zhao H, Chen T, et al. Targeted P2X7/NLRP3 signaling pathway against inflammation, apoptosis, and pyroptosis of retinal endothelial cells in diabetic retinopathy[J]. Cell Death Dis, 2022, 13(4): 336.
[36]
Yoshida GJ. The interplay between apoptosis and ferroptosis mediated by ER stress[J]. Apoptosis, 2020, 25(11-12): 784-785.
[37]
Huang Y, Yuan M, Duan F, et al. Inhibition of endoplasmic reticulum stress by 4-phenylbutyrate alleviates retinal inflammation and the apoptosis of retinal ganglion cells after ocular alkali burn in mice[J]. Inflamm Res, 2022, 71(5-6): 577-590.
[38]
Griffioen AW, Dudley AC. The rising impact of angiogenesis research[J]. Angiogenesis, 2022, 25(4): 435-437.
[39]
Zhang W, Chen Q, Lei C. LncRNA MIAT promotes cell invasion and migration in esophageal cancer[J]. Exp Ther Med, 2020, 19(5): 3267-3274.
[40]
Wang F, Deng H, Chen J, et al. LncRNA MIAT can regulate the proliferation, apoptosis, and osteogenic differentiation of bone marrow-derived mesenchymal stem cells by targeting miR-150-5p[J]. Bioengineered, 2022, 13(3): 6343-6352.
[41]
Azat M, Huojiahemaiti X, Gao R, et al. Long noncoding RNA MIAT: A potential role in the diagnosis and mediation of acute myocardial infarction[J]. Mol Med Rep, 2019, 20(6): 5216-5222.
[42]
Kang Q, Yang C. Oxidative stress and diabetic retinopathy: Molecular mechanisms, pathogenetic role and therapeutic implications[J]. Redox Biol, 2020, 37: 101799.
[43]
Poznyak A, Grechko AV, Poggio P, et al. The Diabetes Mellitus-Atherosclerosis Connection: The Role of Lipid and Glucose Metabolism and Chronic Inflammation[J]. Int J Mol Sci, 2020, 21(5): 1835.
[44]
Zohar K, Giladi E, Eliyahu T, et al. Oxidative Stress and Its Modulation by Ladostigil Alter the Expression of Abundant Long Non-Coding RNAs in SH-SY5Y Cells[J]. Noncoding RNA, 2022, 8(6): 72.
[45]
Xu X, Zhang Y, Kang Y, et al. LncRNA MIAT Inhibits MPP(+)-Induced Neuronal Damage Through Regulating the miR-132/SIRT1 Axis in PC12 Cells[J]. Neurochem Res, 2021, 46(12): 3365-3374.
[46]
Keino H, Horie S, Sugita S. Immune Privilege and Eye-Derived T-Regulatory Cells[J]. J Immunol Res, 2018: 1679197.
[47]
Ou-Yang Y, Liu ZL, Xu CL, et al. miR-223 induces retinal ganglion cells apoptosis and inflammation via decreasing HSP-70 in vitro and in vivo[J]. J Chem Neuroanat, 2020, 104: 101747.
[48]
Chen H, Cho KS, Vu T, et al. Commensal microflora-induced T cell responses mediate progressive neurodegeneration in glaucoma[J]. Nat Commun, 2018, 9(1): 3209.
[49]
Gan J, Huang M, Lan G, et al. High Glucose Induces the Loss of Retinal Pericytes Partly via NLRP3-Caspase-1-GSDMD-Mediated Pyroptosis[J]. Biomed Res Int, 2020: 4510628.
[50]
Tang D, Chen X, Kang R, et al. Ferroptosis: molecular mechanisms and health implications[J]. Cell Res, 2021, 31(2): 107-125.
[51]
Xiao W, Zheng D, Chen X, et al. Long non-coding RNA MIAT is involved in the regulation of pyroptosis in diabetic cardiomyopathy via targeting miR-214-3p[J]. iScience, 2021, 24(12): 103518.
[52]
Vargas J, Hamasaki M, Kawabata T, et al. The mechanisms and roles of selective autophagy in mammals[J]. Nat Rev Mol Cell Biol, 2023, 24(3): 167-185.
[53]
Dehdashtian E, Mehrzadi S, Yousefi B, et al. Diabetic retinopathy pathogenesis and the ameliorating effects of melatonin; involvement of autophagy, inflammation and oxidative stress[J]. Life Sci, 2018, 193: 20-33.
[54]
Jiang F, Lou J, Zheng XM, et al. LncRNA MIAT regulates autophagy and apoptosis of macrophage infected by Mycobacterium tuberculosis through the miR-665/ULK1 signaling axis[J]. Mol Immunol, 2021, 139: 42-49.
[55]
Mohana DS, Mahalaxmi I, Kaavya J, et al. Does epigenetics have a role in age related macular degeneration and diabetic retinopathy?[J]. Genes Dis, 2021, 8(3): 279-286.
[1] 黄威, 刘启, 陈流华, 滕茶香, 区喆建, 刘韩笑, 陈健聪, 张昆松. 新定义的可预测肝癌预后的焦亡相关lncRNA模型[J]. 中华普通外科学文献(电子版), 2023, 17(05): 357-365.
[2] 王永瑞, 孔丽, 王文娟, 李宸宇, 周国宏. 组织蛋白酶B与血管内皮生长因子影响高氧诱导小鼠视网膜新生血管形成的实验研究[J]. 中华眼科医学杂志(电子版), 2019, 09(02): 90-95.
[3] 李传宝, 张传坤, 丁建光, 李永华, 高秀华. 糖尿病视网膜病变患者视网膜新生血管形态与激光治疗效果的关系[J]. 中华诊断学电子杂志, 2014, 02(03): 220-223.
阅读次数
全文


摘要