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中华眼科医学杂志(电子版) ›› 2023, Vol. 13 ›› Issue (04) : 231 -235. doi: 10.3877/cma.j.issn.2095-2007.2023.04.008

综述

角膜巩膜干凹斑的研究进展
唐凯, 刘正峰, 宋佳蔚, 卢秀珍()   
  1. 250002 济南,山东中医药大学附属眼科医院眼科 山东省眼病防治研究院
    250002 济南,山东中医药大学附属眼科医院眼科 山东省眼病防治研究院;250355 济南,山东中医药大学眼科与视光医学院
  • 收稿日期:2022-11-30 出版日期:2023-08-28
  • 通信作者: 卢秀珍
  • 基金资助:
    山东省医药卫生科技发展计划项目(2019WS569,202007020916)

Research progress of corneal and scleral dellen

Kai Tang, Zhengfeng Liu, Jiawei Song, Xiuzhen Lu()   

  1. Department of Ophthalmology, Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine, Shandong Academy of Eye Disease Prevention and Therapy, Jinan 250002, China
    Department of Ophthalmology, Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine, Shandong Academy of Eye Disease Prevention and Therapy, Jinan 250002, China; Ophthalmology & Optometry Medical School, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
  • Received:2022-11-30 Published:2023-08-28
  • Corresponding author: Xiuzhen Lu
引用本文:

唐凯, 刘正峰, 宋佳蔚, 卢秀珍. 角膜巩膜干凹斑的研究进展[J/OL]. 中华眼科医学杂志(电子版), 2023, 13(04): 231-235.

Kai Tang, Zhengfeng Liu, Jiawei Song, Xiuzhen Lu. Research progress of corneal and scleral dellen[J/OL]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2023, 13(04): 231-235.

角膜或巩膜干凹斑是因泪膜分布异常、局部组织干燥脱水引起的角膜缘或巩膜裸露部位的碟形凹陷。有研究结果表明,干凹斑可见于翼状胬肉术后、斜视术后、青光眼大滤过泡、巩膜炎、结膜高度水肿及Graves眼病。患者可无任何不适或仅有轻度异物感。常规治疗方法有眼表润滑药物、人工泪液、加压包眼以及配戴角膜绷带镜等。经局部水化治疗后,干凹斑多数可较快修复;治疗不及时则会发展为组织溃疡和穿孔等严重并发症。

Corneal or scleral dellen are small saucer-like excavations in the corneal periphery or bare sclera, which caused by interruptions of the tear film and local dehydration of tissues. It has been demonstrated that dellen formation was associated with pterygium surgery, strabismus surgery, large filtration blebs, scleritis, severe conjunctival chemosis, Graves′s eye disease, etc. Patients can have no discomfort or only complaints about foreign body sensation and mild discomfort. Conventional treatment approaches include lubrication, artificial tears, patching, and wearing bandage contact lens. The corneoscleral dellen rapidly has been improved after topical hydration therapy with tear-film. The dellen may lead to corneal or scleral perforation, causing serious complications if not discovered and treated in timely.

图2 角膜干凹斑前节光学相干断层扫描成像 可见凹陷处角膜上皮层和基质层变薄,"泪膜湍流"导致结膜隆起边缘泪液堆积(箭头)
表1 角膜和巩膜干凹斑的回顾性研究文献汇总
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