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中华眼科医学杂志(电子版) ›› 2023, Vol. 13 ›› Issue (02) : 94 -98. doi: 10.3877/cma.j.issn.2095-2007.2023.02.006

综述

非编码核糖核酸与白内障相关的研究进展
方蕊, 宋旭东()   
  1. 100730 首都医科大学附属北京同仁医院2021级科学型博士研究生
    100730 首都医科大学附属北京同仁医院 北京同仁眼科中心 北京市眼科研究所 眼科学与视觉科学北京市重点实验室
  • 收稿日期:2022-09-01 出版日期:2023-04-28
  • 通信作者: 宋旭东
  • 基金资助:
    国家自然科学基金项目(82271067)

Research progress of non-coding RNA related to cataract

Rui Fang, Xudong Song()   

  1. Scientific doctoral degree 2021, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
    Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Vision Sciences, Beijing 100730, China
  • Received:2022-09-01 Published:2023-04-28
  • Corresponding author: Xudong Song
引用本文:

方蕊, 宋旭东. 非编码核糖核酸与白内障相关的研究进展[J/OL]. 中华眼科医学杂志(电子版), 2023, 13(02): 94-98.

Rui Fang, Xudong Song. Research progress of non-coding RNA related to cataract[J/OL]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2023, 13(02): 94-98.

不编码蛋白质的核糖核酸(RNA)称为非编码RNA。其中,调控性非编码RNA主要包括微小RNA(miRNA)、长链非编码RNA(lncRNA)和环状RNA(circRNA)。非编码RNA在细胞生长、增殖、分化、凋亡和氧化应激等多种生物学过程中发挥关键作用。近年来,有许多研究发现非编码RNA在白内障的发生与发展中发挥了调控作用,可能成为非手术治疗而具有应用前景的新靶点。本文中笔者就近年来国内外非编码RNA与白内障的相关研究进展进行综述。

Ribonucleic acid (RNA) that does not encode proteins is called non coding RNA. Among them, regulatory non coding RNA mainly includes microRNA (miRNA), long chain non coding RNA (lncRNA) and circular RNA (circRNA). Non coding RNA plays a crucial role in various biological processes such as cell growth, proliferation, differentiation, apoptosis, and oxidative stress. In recent years, it has been demonstrated that non coding RNA plays an important regulatory role in the occurrence and development of cataracts, and may become a promising new target for non-surgical treatment. In this paper, the research progress on non coding RNA and cataract in recent years both domestically and internationally were reviewed.

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